Thyroid Cells Exposed to Simulated Microgravity Conditions – Comparison of the Fast Rotating Clinostat and the Random Positioning Machine

[1]  Albert Sickmann,et al.  Identification of proteins involved in inhibition of spheroid formation under microgravity , 2015, Proteomics.

[2]  Jens Hauslage,et al.  Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat , 2015, PloS one.

[3]  M. Neurath,et al.  From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis , 2015, Archives of Toxicology.

[4]  Marcel Egli,et al.  Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture , 2015, BioMed research international.

[5]  F. S. Ambesi-Impiombato,et al.  How Microgravity Changes Galectin-3 in Thyroid Follicles , 2014, BioMed research international.

[6]  F. Curcio,et al.  A Firmer Understanding of the Effect of Hypergravity on Thyroid Tissue: Cholesterol and Thyrotropin Receptor , 2014, PloS one.

[7]  M. Braun,et al.  Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1 , 2014, Cell Communication and Signaling.

[8]  R. Agarwal,et al.  Nuclear factor κB-dependent regulation of angiogenesis, and metastasis in an in vivo model of thyroid cancer is associated with secreted interleukin-8. , 2014, The Journal of clinical endocrinology and metabolism.

[9]  D. Grimm,et al.  Growing tissues in real and simulated microgravity: new methods for tissue engineering. , 2014, Tissue engineering. Part B, Reviews.

[10]  Ruth Hemmersbach,et al.  Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  W. Roos,et al.  The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  Astrid Horn,et al.  Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission. , 2013, Biomaterials.

[13]  D. Grimm,et al.  Interleukin-6 Expression under Gravitational Stress Due to Vibration and Hypergravity in Follicular Thyroid Cancer Cells , 2013, PloS one.

[14]  Jens Hauslage,et al.  Adaptation of a 2-D Clinostat for Simulated Microgravity Experiments with Adherent Cells , 2013 .

[15]  Jeanne L. Becker,et al.  Using space-based investigations to inform cancer research on Earth , 2013, Nature Reviews Cancer.

[16]  Jens Hauslage,et al.  Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology. , 2013, Astrobiology.

[17]  A. Sickmann,et al.  Interaction of Proteins Identified in Human Thyroid Cells , 2013, International journal of molecular sciences.

[18]  F. Curcio,et al.  Loss of Parafollicular Cells during Gravitational Changes (Microgravity, Hypergravity) and the Secret Effect of Pleiotrophin , 2012, PloS one.

[19]  Ruth Hemmersbach,et al.  Gravity‐sensitive signaling drives 3‐dimensional formation of multicellular thyroid cancer spheroids , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  F. Curcio,et al.  Observing the mouse thyroid sphingomyelin under space conditions: a case study from the MDS mission in comparison with hypergravity conditions. , 2012, Astrobiology.

[21]  F. S. Ambesi-Impiombato,et al.  The Impact of Long-Term Exposure to Space Environment on Adult Mammalian Organisms: A Study on Mouse Thyroid and Testis , 2012, PloS one.

[22]  R. Einspanier,et al.  Differential Gene Regulation under Altered Gravity Conditions in Follicular Thyroid Cancer Cells: Relationship between the Extracellular Matrix and the Cytoskeleton , 2011, Cellular Physiology and Biochemistry.

[23]  R. Wildgruber,et al.  A proteomic approach to analysing spheroid formation of two human thyroid cell lines cultured on a random positioning machine , 2011, Proteomics.

[24]  F. Curcio,et al.  Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity. , 2011, Astrobiology.

[25]  E. Tartour,et al.  Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy , 2011, Cancer and Metastasis Reviews.

[26]  R. Wildgruber,et al.  Application of free‐flow IEF to identify protein candidates changing under microgravity conditions , 2010, Proteomics.

[27]  A. Cogoli,et al.  Neocartilage formation in 1 g, simulated, and microgravity environments: implications for tissue engineering. , 2010, Tissue engineering. Part A.

[28]  D. Grimm,et al.  Blockade of neoangiogenesis, a new and promising technique to control the growth of malignant tumors and their metastases. , 2009, Current vascular pharmacology.

[29]  A. Cogoli,et al.  Modeled gravitational unloading induced downregulation of endothelin‐1 in human endothelial cells , 2007, Journal of cellular biochemistry.

[30]  M. Post,et al.  Stretch‐activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells , 2007, Journal of cellular physiology.

[31]  Jack J. W. A. van Loon,et al.  Some history and use of the random positioning machine, RPM, in gravity related research , 2007 .

[32]  A. Cogoli,et al.  The use of the random positioning machine for the study of gravitational effects on signal transduction in mammalian cells , 2006 .

[33]  M. Shakibaei,et al.  Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system , 2006, Apoptosis.

[34]  Qingbo Xu,et al.  Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-kappaB signaling pathways. , 2005, American journal of physiology. Heart and circulatory physiology.

[35]  G. Schulze-Tanzil,et al.  Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. , 2003, Endocrinology.

[36]  A. Dove Tumor cells , 2003, The Journal of Cell Biology.

[37]  G. Schulze-Tanzil,et al.  Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy. , 2002, American journal of hypertension.

[38]  M. Shakibaei,et al.  Simulated microgravity induces programmed cell death in human thyroid carcinoma cells. , 2002, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

[39]  G. Schulze-Tanzil,et al.  Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  T. Davies,et al.  Thyroid organoid formation in simulated microgravity: influence of keratinocyte growth factor. , 2000, Thyroid : official journal of the American Thyroid Association.

[41]  D. Grimm,et al.  Establishment and characterization of the follicular thyroid carcinoma cell line ML-1 , 2000, Journal of Molecular Medicine.

[42]  Johannes Boonstra,et al.  Growth factor‐induced signal transduction in adherent mammalian cells is sensitive to gravity , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  R. Hemmersbach,et al.  Response to thyrotropin of normal thyroid follicular cell strain FRTL5 in hypergravity. , 1999, Biochimie.

[44]  D. Klaus,et al.  Functional weightlessness during clinorotation of cell suspensions. , 1998, Advances in space research : the official journal of the Committee on Space Research.

[45]  F. Curcio,et al.  Response to hypogravity of normal in vitro cultured follicular cells from thyroid. , 1998, Acta astronautica.

[46]  G. Vunjak‐Novakovic,et al.  Tissue engineering of cartilage in space. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[47]  D. Grimm,et al.  Characteristics of multicellular spheroids formed by primary cultures of human thyroid tumor cells. , 1997, Thyroid : official journal of the American Thyroid Association.

[48]  W. Scherbaum,et al.  Expression of cytokines in the thyroid: thyrocytes as potential cytokine producers , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[49]  C Giuliani,et al.  The thyrotropin receptor. , 1995, Vitamins and hormones.

[50]  H. Coon,et al.  Long-term culture and functional characterization of follicular cells from adult normal human thyroids. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[51]  W Briegleb,et al.  Some qualitative and quantitative aspects of the fast-rotating clinostat as a research tool. , 1992, ASGSB bulletin : publication of the American Society for Gravitational and Space Biology.

[52]  A. Frilling,et al.  Growth regulation of normal thyroids and thyroid tumors in man. , 1990, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[53]  D. Sheer,et al.  Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection. , 1989, British Journal of Cancer.

[54]  M. Feldmann,et al.  Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6. , 1989, Clinical and experimental immunology.