m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway
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T. Shi | Ya-bin Yu | Siqing Zhang | Kai Lin | Jinfan Zhang | Yuetian Pan | Wentao Gao | Ziruo Zheng | Endi Zhou
[1] Xiao-jun Huang,et al. The role of m6A demethylase FTO in chemotherapy resistance mediating acute myeloid leukemia relapse , 2023, Cell death discovery.
[2] A. Jemal,et al. Cancer statistics, 2023 , 2023, CA: a cancer journal for clinicians.
[3] Xiao‐Yu Yin,et al. Imatinib facilitates gemcitabine sensitivity by targeting epigenetically activated PDGFC signaling in pancreatic cancer , 2022, Molecular therapy : the journal of the American Society of Gene Therapy.
[4] Yihang Yu,et al. MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro , 2022, Cells.
[5] Baochi Ou,et al. Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation , 2022, Cell Death & Disease.
[6] Guohui Wan,et al. N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis , 2022, Molecular therapy : the journal of the American Society of Gene Therapy.
[7] A. Goel,et al. Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma , 2022, Pharmaceuticals.
[8] Lianfang Zheng,et al. HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway , 2022, Molecular carcinogenesis.
[9] Jiali Yang,et al. Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer , 2022, Molecular cancer.
[10] Weiqi Wang,et al. RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent manner , 2022, Oncogene.
[11] Chunze Zhang,et al. FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1 , 2022, Clinical and translational medicine.
[12] A. Loguinov,et al. Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216 , 2021, Molecular Cancer Therapeutics.
[13] Fan Wang,et al. LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway , 2021, Cancer Research.
[14] W. Wang,et al. A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression , 2021, Cancer Research.
[15] B. Erickson,et al. Online adaptive MR-guided stereotactic radiotherapy for unresectable malignancies in the upper abdomen using a 1.5T MR-linac , 2021, Acta oncologica.
[16] C. Tisné,et al. A comprehensive review of m6A/m6Am RNA methyltransferase structures , 2021, Nucleic acids research.
[17] Yongyan Wu,et al. Regulatory role and mechanism of m6A RNA modification in human metabolic diseases , 2021, Molecular therapy oncolytics.
[18] Q. Lan,et al. The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance , 2021, Cancer Research.
[19] Cuiping Yang,et al. The role of m6A modification in the biological functions and diseases , 2021, Signal Transduction and Targeted Therapy.
[20] Yan Wang,et al. Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin , 2021, Bioengineered.
[21] Schraga Schwartz,et al. The epitranscriptome beyond m6A , 2020, Nature Reviews Genetics.
[22] D. Saur,et al. Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component , 2020, bioRxiv.
[23] Zhou Wang,et al. Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance , 2020, Investigational New Drugs.
[24] Yun Feng,et al. RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner , 2020, Molecular Cancer.
[25] S. Ju,et al. The potential role of RNA N6-methyladenosine in Cancer progression , 2020, Molecular Cancer.
[26] W. Xie,et al. m6A-binding proteins: the emerging crucial performers in epigenetics , 2020, Journal of Hematology & Oncology.
[27] E. Hirsch,et al. PI(3,4)P2 Signaling in Cancer and Metabolism , 2020, Frontiers in Oncology.
[28] Weifeng Hong,et al. Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival , 2020, Annals of translational medicine.
[29] Z. Qiu,et al. Akt inhibitor MK-2206 reduces pancreatic cancer cell viability and increases the efficacy of gemcitabine. , 2020, Oncology letters.
[30] Dewei Wang,et al. Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease , 2020, Frontiers in Neuroscience.
[31] F. Shimamoto,et al. m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling , 2020, Molecular Cancer.
[32] Y. Miao,et al. The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion. , 2019, Pathology, research and practice.
[33] C. Pilarsky,et al. Chemoresistance in Pancreatic Cancer , 2019, International journal of molecular sciences.
[34] G. Mills,et al. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation , 2019, Breast Cancer Research.
[35] Hualiang Jiang,et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. , 2019, Cancer cell.
[36] E. Hirsch,et al. Class II PI3K Functions in Cell Biology and Disease. , 2019, Trends in cell biology.
[37] I. Bezsonova,et al. USP7: Structure, substrate specificity, and inhibition. , 2019, DNA repair.
[38] Min Gyu Lee,et al. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression , 2019, Nature Communications.
[39] Sicong Zhang. Mechanism of N6-methyladenosine modification and its emerging role in cancer. , 2018, Pharmacology & therapeutics.
[40] R. Hajjar,et al. FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair , 2018, Circulation.
[41] S. Naderi,et al. MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent. , 2018, Atherosclerosis.
[42] M. Ghosh,et al. Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases , 2018, Signal Transduction and Targeted Therapy.
[43] T. Yokobori,et al. Investigation into metastatic processes and the therapeutic effects of gemcitabine on human pancreatic cancer using an orthotopic SUIT-2 pancreatic cancer mouse model. , 2017, Oncology letters.
[44] Lewis C. Cantley,et al. The PI3K Pathway in Human Disease , 2017, Cell.
[45] Jianguo Sun,et al. Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non–small-cell lung cancer , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
[46] Amjad Ali,et al. USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein. , 2017, The Biochemical journal.
[47] Haidi Yang,et al. NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells , 2017, Cell cycle.
[48] K. Olive,et al. Current and Emerging Therapies in Metastatic Pancreatic Cancer , 2017, Clinical Cancer Research.
[49] S. Lakhani,et al. DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer , 2017, Oncogene.
[50] J. Cameron,et al. Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma , 2017, Annals of surgery.
[51] Q. Fu,et al. miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN , 2016, Nature Communications.
[52] T. Conroy,et al. Current standards and new innovative approaches for treatment of pancreatic cancer. , 2016, European journal of cancer.
[53] S. Na'ara,et al. Gemcitabine resistance in pancreatic ductal adenocarcinoma. , 2015, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[54] W. Duan,et al. Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. , 2014, Cancer letters.
[55] D. Iliopoulos,et al. MicroRNA-gene signaling pathways in pancreatic cancer. , 2013, Biomedical journal.
[56] Simon Hess,et al. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry , 2013, Nature Neuroscience.
[57] Gideon Rechavi,et al. Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing , 2013, Nature Protocols.
[58] Rugang Zhang,et al. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. , 2011, Molecular cell.
[59] Malte Buchholz,et al. Stromal biology and therapy in pancreatic cancer , 2010, Gut.
[60] Roger D. Cox,et al. Overexpression of Fto leads to increased food intake and results in obesity , 2010, Nature Genetics.
[61] J. Schellens,et al. Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy. , 2008, The oncologist.
[62] Lewis C. Cantley,et al. AKT/PKB Signaling: Navigating Downstream , 2007, Cell.
[63] D. Liu,et al. The HAUSP gene plays an important role in non‐small cell lung carcinogenesis through p53‐dependent pathways , 2006, The Journal of pathology.
[64] K. Jauch,et al. Tyrosine kinase inhibitors and gemcitabine: new treatment options in pancreatic cancer? , 2006, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[65] M. Khaled,et al. PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes , 2004, Cell Death and Differentiation.
[66] Godefridus J Peters,et al. Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine). , 2002, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[67] D. V. Von Hoff,et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[68] Y Z Xu,et al. Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation. , 1992, Cancer research.
[69] L. Hertel,et al. Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine). , 1990, Cancer research.
[70] G. Moore,et al. Human cell line (COLO 357) of metastatic pancreatic adenocarcinoma , 1980, International journal of cancer.
[71] Sarfraz Ahmad,et al. Gemcitabine: A Review of Chemoresistance in Pancreatic Cancer. , 2019, Critical reviews in oncogenesis.
[72] Wei Huang,et al. Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5. , 2015, The Journal of clinical endocrinology and metabolism.
[73] V. Speirs,et al. The potential utility of geminin as a predictive biomarker in breast cancer , 2013, Breast Cancer Research and Treatment.
[74] Hilde van der Togt,et al. Publisher's Note , 2003, J. Netw. Comput. Appl..
[75] G. Peters,et al. Antitumor activity of prolonged as compared with bolus administration of 2′,2′-difluorodeoxycytidine in vivo against murine colon tumors , 1996, Cancer Chemotherapy and Pharmacology.