Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).

[1]  L. Scorrano,et al.  The mitochondrial permeability transition , 2022, BioFactors.

[2]  C. Palmeira,et al.  Mitochondrially mediated synergistic cell killing by bile acids. , 2003, Biochimica et biophysica acta.

[3]  I. Grattagliano,et al.  Hepatic oxidative alterations in patients with extra-hepatic cholestasis. Effect of surgical drainage. , 2002, Journal of hepatology.

[4]  P. Oliveira,et al.  Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate. , 2002, Toxicology and applied pharmacology.

[5]  Raquel Seiça,et al.  Disruption of Mitochondrial Calcium Homeostasis after Chronic α-Naphthylisothiocyanate Administration: Relevance for Cholestasis , 2002, Journal of Investigative Medicine.

[6]  S. Glaser,et al.  Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[7]  P. Oliveira,et al.  Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[8]  R. Sokol,et al.  Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis. , 2000, Toxicology and applied pharmacology.

[9]  P. Muriel,et al.  Role of glutathione, lipid peroxidation and antioxidants on acute bile-duct obstruction in the rat. , 1999, Biochimica et biophysica acta.

[10]  G. Gores,et al.  Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases. , 1998, Biochimica et biophysica acta.

[11]  D. Brenner,et al.  The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. , 1998, Biochimica et biophysica acta.

[12]  M. Schäfer,et al.  Reversibility of hepatic mitochondrial damage in rats with long-term cholestasis. , 1998, Journal of hepatology.

[13]  C. Palmeira,et al.  Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones. , 1997, Toxicology and applied pharmacology.

[14]  U. Spengler,et al.  Hepatic levels of bile acids in end-stage chronic cholestatic liver disease. , 1996, Clinica chimica acta; international journal of clinical chemistry.

[15]  B. Winklhofer-Roob,et al.  Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. , 1995, Gastroenterology.

[16]  S. Krähenbühl,et al.  Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats , 1995, Hepatology.

[17]  M. Zoratti,et al.  The mitochondrial permeability transition. , 1995, Biochimica et biophysica acta.

[18]  P. Petit,et al.  Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis , 1995, The Journal of cell biology.

[19]  G. Gores,et al.  Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. , 1995, The Journal of pharmacology and experimental therapeutics.

[20]  C. Palmeira,et al.  Interactions of herbicides 2,4-D and dinoseb with liver mitochondrial bioenergetics. , 1994, Toxicology and applied pharmacology.

[21]  Grishin Ev,et al.  Generation of hydroperoxides during fermentational oxidation of heat stabile comuton from rat liver , 1994 .

[22]  I. Reynolds,et al.  Calcium green-5N, a novel fluorescent probe for monitoring high intracellular free Ca2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons , 1993, Neuroscience Letters.

[23]  R. Sokol,et al.  Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes , 1993, Hepatology.

[24]  P. Meunier,et al.  Temporal relationship of changes in hepatobiliary function and morphology in rats following alpha-naphthylisothiocyanate (ANIT) administration. , 1993, Toxicology and applied pharmacology.

[25]  S. Krähenbühl,et al.  Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis , 1992, Hepatology.

[26]  R. Sokol,et al.  Effect of dietary lipid and vitamin E on mitochondrial lipid peroxidation and hepatic injury in the bile duct-ligated rat. , 1991, Journal of lipid research.

[27]  J. Bancroft,et al.  Theory and Practice of Histological Techniques , 1990 .

[28]  M. Dempsey,et al.  Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. , 1989, The Journal of biological chemistry.

[29]  G. Plaa,et al.  The effect of alpha-naphthylisothiocyanate on bile secretion prior to and during the onset of cholestasis in the rat. , 1982, Toxicology letters.

[30]  N. Kamo,et al.  Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state , 1979, The Journal of Membrane Biology.

[31]  B. Priestly,et al.  Intrahepatic cholestasis induced by drugs and chemicals. , 1976, Pharmacological reviews.

[32]  H. Popper,et al.  Mechanism of cholestasis. 6. Bile acids in human livers with or without biliary obstruction. , 1972, Gastroenterology.

[33]  H. Popper,et al.  Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation. , 1972, Gastroenterology.

[34]  H. Denk,et al.  Mechanism of cholestasis. 4. Structural and biochemical changes in the liver and serum in rats after bile duct ligation. , 1971, Gastroenterology.

[35]  E. J. Singer,et al.  Experimental cholangitis due to alpha-naphthyl-isothiocyanate (ANIT). , 1962, The American journal of pathology.

[36]  H. Taussky,et al.  A microcolorimetric method for the determination of inorganic phosphorus. , 1953, The Journal of biological chemistry.

[37]  A. Gornall,et al.  Determination of serum proteins by means of the biuret reaction. , 1949, The Journal of biological chemistry.

[38]  S. Kharb Toxicology , 1936 .

[39]  A. Starkov,et al.  Mitochondrial targets of drug toxicity. , 2000, Annual review of pharmacology and toxicology.

[40]  L. Packer,et al.  Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. , 1998, Gastroenterology.

[41]  G. Gores,et al.  Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E. , 1997, Toxicology and applied pharmacology.

[42]  P. Gazzotti,et al.  Membrane Biochemistry , 1979, Springer Berlin Heidelberg.

[43]  E. C. Slater THE RESPIRATORY CHAIN AND OXIDATIVE PHOSPHORYLATION , 1972 .

[44]  R. Roberts,et al.  Disposition of the hepatotoxin alpha-naphthylisothiocyanate (ANIT) in the rat. , 1970, Toxicology and applied pharmacology.