Crosstalk between NF-κB and β-catenin pathways in bacterial-colonized intestinal epithelial cells

Salmonella-epithelial cell interactions are known to activate the proinflammatory NF-κB signaling pathway and have recently been found to also influence the β-catenin signaling pathway, an importan...

[1]  Jun Sun,et al.  Bacterial activation of β-catenin signaling in human epithelia , 2004 .

[2]  M. Hung,et al.  Crossregulation of NF‐κB by the APC/GSK‐3β/β‐catenin pathway , 2004, Molecular carcinogenesis.

[3]  Xiaohong Wang,et al.  The Role of &bgr;-Transducin Repeat-Containing Protein (&bgr;-TrCP) in the Regulation of NF-&kgr;B in Vascular Smooth Muscle Cells , 2004 .

[4]  F. Guarner,et al.  Gut flora in health and disease , 2003, The Lancet.

[5]  R. Gaynor,et al.  IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. , 2003, Molecular biology of the cell.

[6]  M. Hung,et al.  β-catenin interacts with and inhibits NF-κB in human colon and breast cancer , 2002 .

[7]  Jun Sun,et al.  Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway1 , 2002, The Journal of Immunology.

[8]  K. Kinzler,et al.  Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  I. Ellis,et al.  The Wnt pathway, epithelial–stromal interactions, and malignant progression in phyllodes tumours , 2002, The Journal of pathology.

[10]  Michael Karin,et al.  NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.

[11]  M. Pignatelli,et al.  β-catenin - A linchpin in colorectal carcinogenesis? , 2002 .

[12]  E. Schmidt,et al.  IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development , 2001, Cell.

[13]  P. Polakis More Than One Way to Skin a Catenin , 2001, Cell.

[14]  F. Shanahan,et al.  Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. , 2001, Gastroenterology.

[15]  M. Merville,et al.  Nuclear factor-kappa B, cancer, and apoptosis. , 2000, Biochemical pharmacology.

[16]  A. Young,et al.  Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination , 2000 .

[17]  P. Polakis Wnt signaling and cancer. , 2000, Genes & development.

[18]  J. Woodgett,et al.  Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation , 2000, Nature.

[19]  Thomas Kirchner,et al.  β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer , 1999 .

[20]  C. Albanese,et al.  The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  F. van Roy,et al.  Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. , 1999, Cancer research.

[22]  Y. Xiong,et al.  HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin , 1999, Oncogene.

[23]  D. Rimm,et al.  Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. , 1999, The American journal of pathology.

[24]  Stephen J. Elledge,et al.  The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro , 1999 .

[25]  R. Sartor,et al.  Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice , 1998, Infection and Immunity.

[26]  C. Y. Wang,et al.  NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. , 1998, Science.

[27]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[28]  R. Knuechel,et al.  Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. , 1998, Gastroenterology.

[29]  P. Möller,et al.  Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis. , 1998, Cancer research.

[30]  W. Hardt,et al.  A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[31]  D. White,et al.  Rel/NF-kappaB/IkappaB proteins and cancer. , 1996, Oncogene.

[32]  D. Melton,et al.  A molecular mechanism for the effect of lithium on development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[33]  R. Sartor Insights into the pathogenesis of inflammatory bowel diseases provided by new rodent models of spontaneous colitis , 1995 .

[34]  K. Kinzler,et al.  Association of the APC tumor suppressor protein with catenins. , 1993, Science.

[35]  S. Miller,et al.  Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils , 1993, The Journal of cell biology.

[36]  W. Strober,et al.  Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice , 1993, Cell.

[37]  S. Miller,et al.  Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages , 1990, Journal of bacteriology.

[38]  J. Madara,et al.  Occluding junction structure-function relationships in a cultured epithelial monolayer , 1985, The Journal of cell biology.

[39]  Jun Sun,et al.  Bacterial activation of beta-catenin signaling in human epithelia. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[40]  K. Kinzler,et al.  Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Manfred Dietel,et al.  Mucosal flora in inflammatory bowel disease. , 2002, Gastroenterology.

[42]  A. Young,et al.  Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. , 2000, Science.

[43]  T. Brabletz,et al.  beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. , 1999, The American journal of pathology.

[44]  F. McCormick,et al.  Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. , 1999, Nature.

[45]  Douglas B. Evans,et al.  The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells , 1999 .

[46]  Y. Xiong,et al.  HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. , 1999, Oncogene.

[47]  M J May,et al.  NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.

[48]  R. Sartor Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. , 1997, The American journal of gastroenterology.

[49]  R. Sartor,et al.  Microbial factors in chronic intestinal inflammation , 1996 .