Symposium “Limiting of Infarct Size”

Much has been learned in the past twenty years about the biologic changes occurring in zones of acute myocardial ischemic injury. Almost all of this information has come from studies of regional ischemia in dogs or other experimental animals. In this paper, the changes which occur when myocardium is made acutely and severely ischemic by sudden occlusion of a major branch of a coronary artery in the dog will be reviewed with special attention to those changes which are associated with irreversible (lethal) injury.

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