Ultrastructure of the normal lymph node.

The "normal" lymph node has been studied by electron microscopy. The lymphoid tissue can be divided into three distinct zones. Zone 1 consists of loosely arranged cells surrounding the lymphatic sinuses and blood vessels. This is the only zone in which plasma cells are present. Zone 2 is surrounded by zone 1 and consists of compactly arranged cells in which lymphocytes predominate. Zone 3 (germinal center) appears only after antigenic stimulation. It is characterized by large, ribosome-rich cells and macrophages containing phagocytosed lymphocytes. These zones are arranged with their longest diameters pointing towards the hilus. Zone 1 is the longest and extends across the cortex, paracortex and medulla. Zone 2 spans across cortex and paracortex. Zone 3 usually is confined to the cortex. Our preliminary studies indicate that zone 1 is mainly bursal dependent, zone 2 is mainly thymic dependent and zone 3 is bursal dependent.

[1]  G. Simon,et al.  Phagocytosis of colloidal carbon in a lymph node. , 1971, The American journal of pathology.

[2]  J. A. Sharp,et al.  Electron Microscopic Atlas of Lymph Node Cytology and Pathology , 1970 .

[3]  M. Mori,et al.  Studies on the germinal center. I. Ultrastructural study of germinal centers in human lymph nodes with correspondence to the zonal differentiation. , 1969, Journal of the Reticuloendothelial Society.

[4]  C. Turnbull,et al.  PEPSIN DIGESTION OF VIRUS PARTICLES IN CANINE HEPATITIS USING EPON-EMBEDDED MATERIAL , 1967, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[5]  F. L. Adler,et al.  Antibody formation initiated in vitro. 3. Antibody formation and allotypic specificity directed by ribonucleic acid from peritoneal exudate cells. , 1966, Journal of immunology.

[6]  J. Turk,et al.  A HISTOLOGICAL AND AUTORADIOGRAPHIC STUDY OF LYMPH NODES DURING THE DEVELOPMENT OF CONTACT SENSITIVITY IN THE GUINEA-PIG. , 1965, British journal of experimental pathology.

[7]  R. G. White.  Fine Structure of the Normal and Malignant Human Lymph Node , 1965 .

[8]  H. Movat,et al.  THE FINE STRUCTURE OF THE LYMPHOID TISSUE DURING ANTIBODY FORMATION. , 1965, Experimental and molecular pathology.

[9]  H. Movat,et al.  THE FINE STRUCTURE OF LYMPHOID TISSUE. , 1964, Experimental and molecular pathology.

[10]  R. Moore,et al.  CYTOPLASMIC INTERACTION BETWEEN MACROPHAGES AND LYMPHOCYTIC CELLS IN ANTIBODY SYNTHESIS. , 1964, Science.

[11]  R. Moe,et al.  ELECTRON MICROSCOPIC APPEARANCE OF THE PARENCHYMA OF LYMPH NODES. , 1964, The American journal of anatomy.

[12]  K. Maruyama,et al.  [ELECTRON MICROSCOPIC STUDIES ON GERMINAL CENTER CELLS OF THE LYMPH NODE]. , 1964, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society.

[13]  V. Marchesi,et al.  The migration of lymphocytes through the endothelium of venules in lymph nodes: an electron microscope study , 1964, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[14]  R. Moe.  Fine structure of the reticulum and sinuses of lymph nodes , 1963 .

[15]  F. L. Adler,et al.  ANTIBODY FORMATION INITIATED IN VITRO , 1963, The Journal of experimental medicine.

[16]  S. L. Clark.  The reticulum of lymph nodes in mice studied with the electron microscope. , 1962, The American journal of anatomy.

[17]  M. Karnovsky.  SIMPLE METHODS FOR "STAINING WITH LEAD" AT HIGH pH IN ELECTRON MICROSCOPY , 1961, The Journal of biophysical and biochemical cytology.

[18]  S. Han,et al.  The ultrastructure of the mesenteric lymph node of the rat. , 1961, The American journal of anatomy.

[19]  John H. Luft,et al.  IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODS , 1961, The Journal of biophysical and biochemical cytology.

[20]  G. Sorenson.  An electron microscopic study of popliteal lymph nodes from rabbits , 1960 .

[21]  E. Gall.  THE CYTOLOGICAL IDENTITY AND INTERRELATION OF MESENCHYMAL CELLS OF LYMPHOID TISSUE , 1958, Annals of the New York Academy of Sciences.

[22]  L. Weiss.  A STUDY OF THE STRUCTURE OF SPLENIC SINUSES IN MAN AND IN THE ALBINO RAT WITH THE LIGHT MICROSCOPE AND THE ELECTRON MICROSCOPE , 1957, The Journal of biophysical and biochemical cytology.

[23]  H. Braunsteiner,et al.  Demonstration of a cytoplasmic structure in plasma cells. , 1953, Blood.

[24]  D. Drabkin,et al.  NUCLEIC ACIDS AND THE PRODUCTION OF ANTIBODY BY PLASMA CELLS , 1949, The Journal of experimental medicine.

[25]  G. Simon,et al.  Electron microscopy of the spleen. I. Anatomy and microcirculation. , 1970, The American journal of pathology.

[26]  G. Simon,et al.  Electron microscopy of the spleen. II. Phagocytosis of colloidal carbon. , 1970, American Journal of Pathology.

[27]  M. Hanna,et al.  Lymphatic Tissue and Germinal Centers in Immune Response , 1969, Advances in Experimental Medicine and Biology.