2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A.
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E. Sugaru | T. Nakagawa | H. Kimura | J. Deguchi | M. Horiguchi | Mutsuko Sakai | N. Sawada | Y. Nishio | M. Ono | H. Nakahira | Y. Furuta | M. Otani | Y. Masui | Y. Honda | Takahiko Hashizuka