Ubiquitin pathway: Another link in the polyubiquitin chain?

Polyubiquitin has long been recognised as an intracellular signal. It now appears that different lysine linkages between the ubiquitin moieties are recognised as distinct signals and act in different cell processes. The generation of these different polyubiquitin chains may play an important part in the life of a cell.

[1]  D. Ecker,et al.  Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant , 1994, Molecular and cellular biology.

[2]  P. Sung,et al.  DNA repair genes and proteins of Saccharomyces cerevisiae. , 1993, Annual review of genetics.

[3]  A. Ciechanover,et al.  The ubiquitin system. , 1998, Annual review of biochemistry.

[4]  Q. Deveraux,et al.  A 26 S protease subunit that binds ubiquitin conjugates. , 1994, The Journal of biological chemistry.

[5]  I. Ota,et al.  A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal (*) , 1995, The Journal of Biological Chemistry.

[6]  A. Haas,et al.  A ubiquitin mutant with specific defects in DNA repair and multiubiquitination , 1995, Molecular and cellular biology.

[7]  C. Pickart Targeting of substrates to the 26S proteasome , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  C. Pickart,et al.  Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair , 1999, Cell.

[9]  M. Ellison,et al.  Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain , 1994, Molecular and cellular biology.

[10]  S. Jentsch,et al.  A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly , 1999, Cell.

[11]  A. Varshavsky,et al.  The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. , 1991, Proceedings of the National Academy of Sciences of the United States of America.