The ultrasonix 500RP: A commercial ultrasound research interface

Unlike researchers in magnetic resonance imaging who have considerable access to high level tools and to data at a very basic level on their scanners, those involved with ultrasound have found little in the way of meaningful and widespread access to even the most basic echo signals in their clinical systems. Interest has emerged, however, in ultrasound research interfaces on commercial scanners to provide access to raw ultrasound data and control of basic research functions. This paper describes initial experience gained on one such ultrasound system. The Ultrasonix 500RP system provides research access to the data at multiple points in the signal processing chain and allows control over most imaging parameters. The Ultrasonix system allows for three methods of research control. One is implemented along with the standard clinical imaging software using "mouseover" screens on the periphery of the application window. These screens are configured by the user to display various signal processing variables, which can be modified in real time. Second, the system can be controlled via a user-written remote control client application interacting through the clinical exam software. Lastly, the user can write a complete application which initializes the basic ultrasound module but need not use the Ultrasonix clinical exam software. All of the modes can be done locally on the scanner itself or via a network, and are based on software developed in C++ with libraries supplied with the scanner. Two examples are presented in this paper from the evaluation of the system in "real world" applications. Measurements of absolute backscatter coefficients and attenuation coefficients versus frequency are shown and elastograms utilizing spatial compounding are described

[1]  Travis N. Blalock,et al.  Development of a parallel acquisition system for ultrasound research , 2001, SPIE Medical Imaging.

[2]  J A Zagzebski,et al.  Ultrasound attenuation and backscatter in the liver during prednisone administration. , 1997, Ultrasound in medicine & biology.

[3]  J. G. Miller,et al.  Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements. , 1999, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[4]  T. Varghese,et al.  Noise reduction using spatial-angular compounding for elastography , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  J A Zagzebski,et al.  Quantitative Ultrasound Imaging: in Vivo Results in Normal Liver , 1993, Ultrasonic imaging (Print).

[6]  F. Dunn,et al.  Comprehensive compilation of empirical ultrasonic properties of mammalian tissues. , 1978, The Journal of the Acoustical Society of America.

[7]  T. Varghese,et al.  Direct strain estimation in elastography using spectral cross-correlation. , 2000, Ultrasound in medicine & biology.

[8]  G R Sutherland,et al.  Is there a change in myocardial nonlinearity during the cardiac cycle? , 2001, Ultrasound in medicine & biology.

[9]  F. Dunn,et al.  Ultrasonic Scattering in Biological Tissues , 1992 .

[10]  H. Ermert,et al.  Diagnosis of prostate carcinoma using multicompression strain imaging: data acquisition and first in vivo results , 1998, 1998 IEEE Ultrasonics Symposium. Proceedings (Cat. No. 98CH36102).

[11]  J.A. Jensen,et al.  Ultrasound research scanner for real-time synthetic aperture data acquisition , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[12]  William F. Walker,et al.  Evaluation of translating apertures based angular scatter imaging on a clinical imaging system , 2001, 2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263).

[13]  F. Kallel,et al.  Tradeoffs in Elastographic Imaging , 2001, Ultrasonic imaging.

[14]  L. X. Yao,et al.  Backscatter Coefficient Measurements Using a Reference Phantom to Extract Depth-Dependent Instrumentation Factors , 1990, Ultrasonic imaging.

[15]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.

[16]  E. Madsen,et al.  Interlaboratory Comparison of Ultrasonic Backscatter Coefficient Measurements From 2 to 9 MHz , 2005, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[17]  Tomy Varghese,et al.  Spatial-angular compounding for elastography using beam steering on linear array transducers. , 2006, Medical physics.

[18]  Mickael Tanter,et al.  MR elastography of breast lesions: Understanding the solid/liquid duality can improve the specificity of contrast‐enhanced MR mammography , 2007, Magnetic resonance in medicine.

[19]  E L Madsen,et al.  Elastographic Imaging Using a Handheld Compressor , 2002, Ultrasonic imaging.

[20]  L. Heuser,et al.  Freehand ultrasound elastography of breast lesions: clinical results. , 2001, Ultrasound in medicine & biology.

[21]  F. Kallel,et al.  A Least-Squares Strain Estimator for Elastography , 1997, Ultrasonic imaging.

[22]  William D. O'Brien,et al.  Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging , 2004, IEEE Transactions on Medical Imaging.

[23]  B. Garra,et al.  Elastography of breast lesions: initial clinical results. , 1997, Radiology.

[24]  Robert Rohling,et al.  PUPIL: Programmable Ultrasound Platform and Interface Library , 2003, International Conference on Medical Image Computing and Computer-Assisted Intervention.

[25]  Tomy Varghese,et al.  Improvements in elastographic contrast-to-noise ratio using spatial-angular compounding. , 2005, Ultrasound in medicine & biology.

[26]  J. Faran Sound Scattering by Solid Cylinders and Spheres , 1951 .

[27]  C. S. Spalding,et al.  In vivo real-time freehand palpation imaging. , 2003, Ultrasound in medicine & biology.

[28]  T. Varghese,et al.  Normal and shear strain estimation using beam steering on linear-array transducers. , 2007, Ultrasound in medicine & biology.

[29]  Tomy Varghese,et al.  Estimation of displacement vectors and strain tensors in elastography using angular insonifications , 2004 .

[30]  G G Cox,et al.  Ultrasonic measurement of glomerular diameters in normal adult humans. , 1996, Ultrasound in medicine & biology.

[31]  Michael F Insana,et al.  Strain imaging of internal deformation. , 2002, Ultrasound in medicine & biology.

[32]  M. O’Donnell,et al.  Reconstructive ultrasound elasticity imaging for renal pathology detection , 1997, 1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118).

[33]  E W Olcott,et al.  Liver tumors: utility of characterization at dual-frequency US. , 1999, Radiology.

[34]  T. Varghese,et al.  Tissue-Mimicking Oil-in-Gelatin Dispersions for Use in Heterogeneous Elastography Phantoms , 2003, Ultrasonic imaging.