Thymus graft reconstitution of T‐cell‐deprived mice infected with Trypanosoma musculi

T‐cell‐deprived CBA mice were given thymus graft implants during the course of an infection with Trypanosoma musculi and at a time when the parasitaemia was high. As a consequence of the grafts, most of the mice survived the infection whereas control ungrafted mice died. In grafted animals there was generally a period of 6&80 days after grafting during which time parasitic numbers remained high, and a further period of 200 or more days when trypanosomes were still detectable in the circulation. The mice were highly variable in their responses and possible reasons for this are considered.

[1]  B. Bo,et al.  Thymus dependency of Trypanosoma musculi elimination from mice. , 1977 .

[2]  R. Rank,et al.  Chronic infection with Trypanosoma musculi in congenitally athymic nude mice , 1977, Infection and immunity.

[3]  B. O. Brooks,et al.  Thymus dependency of Trypanosoma musculi elimination from mice. , 1977, Journal of the Reticuloendothelial Society.

[4]  G. Targett,et al.  Ablastin: control of Trypanosoma musculi infections in mice. , 1975, Experimental parasitology.

[5]  G. Targett,et al.  The immunological response of CBA mice to Trypanosoma musculi: mechanisms of protective immunity. , 1975, International journal for parasitology.

[6]  G. Targett,et al.  The immunological response of CBA mice to Trypanosoma musculi: elimination of the parasite from the blood. , 1975, International journal for parasitology.

[7]  G. Targett,et al.  The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation. , 1974, Clinical and experimental immunology.

[8]  G. Targett,et al.  The persistance of Trypanosoma (Herpetosoma) musculi in the kidneys of immune CBA mice. , 1972, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[9]  M. Doenhoff,et al.  Reconstitution of the T-cell pool after irradiation of mice. , 1971, Cellular immunology.

[10]  P. Koller,et al.  THE MITOTIC RESPONSE OF THYMUS‐DERIVED CELLS TO ANTIGENIC STIMULUS , 1966, Transplantation.

[11]  S. Rose,et al.  REVERSAL OF THE THYMUS-DEPENDENT INFLUENCE IN RADIATION LEUKEMOGENESIS OF C57BL MICE. , 1963, Journal of the National Cancer Institute.