Elevated Chemokine Responses Are Maintained in Lungs after Clearance of Viral Infection

ABSTRACT We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated through 29 days postinfection.

[1]  R. Zuberi,et al.  Chemokine induction and leukocyte trafficking to the lungs during murine gammaherpesvirus 68 (MHV-68) infection. , 2002, Virology.

[2]  P. Stevenson,et al.  A Secreted Chemokine Binding Protein Encoded by Murine Gammaherpesvirus-68 Is Necessary for the Establishment of a Normal Latent Load , 2001, The Journal of experimental medicine.

[3]  A. Clavo,et al.  Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice , 2001, Journal of Virology.

[4]  B. Dutia,et al.  Murine gammaherpesvirus-68 infection causes multi-organ fibrosis and alters leukocyte trafficking in interferon-gamma receptor knockout mice. , 2001, The American journal of pathology.

[5]  S. Kunkel,et al.  III. Chemokines and other mediators, 8. Chemokines and their receptors in cell‐mediated immune responses in the lung , 2001, Microscopy research and technique.

[6]  J. Stewart,et al.  Characterization of the murine gammaherpesvirus 68 ORF74 product: a novel oncogenic G protein-coupled receptor. , 2001, The Journal of general virology.

[7]  H. Rosenberg,et al.  MIP-1alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in mice. , 2000, Cellular immunology.

[8]  D. Fremont,et al.  Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action , 2000, Journal of Virology.

[9]  L. Anderson,et al.  Respiratory Syncytial Virus G and/or SH Glycoproteins Modify CC and CXC Chemokine mRNA Expression in the BALB/c Mouse , 2000, Journal of Virology.

[10]  Y. Iwakura,et al.  Chemokine synthesis and cellular inflammatory changes in lungs of mice bearing p40tax of human T‐lymphotropic virus type 1 , 2000, Clinical and experimental immunology.

[11]  K. Dyer,et al.  Pulmonary eosinophilia and production of MIP-1alpha are prominent responses to infection with pneumonia virus of mice. , 2000, Cellular immunology.

[12]  A. Alcamí,et al.  A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus , 2000, The Journal of experimental medicine.

[13]  T. Schall,et al.  Cytomegalovirus encodes a potent alpha chemokine. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[14]  B. Stripp,et al.  Clara cell secretory protein decreases lung inflammation after acute virus infection. , 1998, American journal of physiology. Lung cellular and molecular physiology.

[15]  S. Efstathiou,et al.  Murine gammaherpesvirus 68: a model for the study of gammaherpesvirus pathogenesis. , 1998, Trends in microbiology.

[16]  G. Johnson,et al.  Intracellular Signaling by the Chemokine Receptor US28 during Human Cytomegalovirus Infection , 1998, Journal of Virology.

[17]  T. Schulz,et al.  Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). , 1998, The Journal of general virology.

[18]  E. Usherwood,et al.  Lung Epithelial Cells Are a Major Site of Murine Gammaherpesvirus Persistence , 1998, The Journal of experimental medicine.

[19]  A. Luster,et al.  Chemokines--chemotactic cytokines that mediate inflammation. , 1998, The New England journal of medicine.

[20]  T. Standiford,et al.  Therapeutic Effects of Nitric Oxide Inhibition during Experimental Fecal Peritonitis: Role of Interleukin-10 and Monocyte Chemoattractant Protein 1 , 1998, Infection and Immunity.

[21]  P. Doherty,et al.  Kinetic Analysis of the Specific Host Response to a Murine Gammaherpesvirus , 1998, Journal of Virology.

[22]  T. Standiford,et al.  Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality , 1997, Infection and immunity.

[23]  P. Latreille,et al.  Complete sequence and genomic analysis of murine gammaherpesvirus 68 , 1997, Journal of virology.

[24]  D. Taub Chemokine-leukocyte interactions. The voodoo that they do so well. , 1996, Cytokine & growth factor reviews.

[25]  P. Doherty,et al.  Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells , 1996, The Journal of experimental medicine.

[26]  A. Nash,et al.  Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo. , 1992, The Journal of general virology.

[27]  A. Nash,et al.  Virological and pathological features of mice infected with murine gamma-herpesvirus 68. , 1992, The Journal of general virology.

[28]  T. Mosmann,et al.  Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. , 1990, Science.

[29]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[30]  J. Rajčáni,et al.  Experimental pathogenesis of murine herpesvirus in newborn mice. , 1984, Acta virologica.

[31]  G. Russ,et al.  Antigenic relatedness of alphaherpesviruses isolated from free-living rodents. , 1982, Acta virologica.

[32]  J. Svobodova,et al.  Growth characteristics of herpesviruses isolated from free living small rodents. , 1982, Acta virologica.

[33]  J. Svobodova,et al.  Isolation of five strains of herpesviruses from two species of free living small rodents. , 1980, Acta virologica.

[34]  Geoffrey L. Smith,et al.  Vaccinia virus immune evasion. , 1999, Immunology letters.

[35]  N. Saederup,et al.  Cytomegalovirus encodes a potent a chemokine , 1999 .

[36]  J. Rajčáni,et al.  Pathogenesis of acute and persistent murine herpesvirus infection in mice. , 1985, Acta virologica.