Focused review: spinal anesthesia in severe preeclampsia.

Spinal anesthesia is widely regarded as a reasonable anesthetic option for cesarean delivery in severe preeclampsia, provided there is no indwelling epidural catheter or contraindication to neuraxial anesthesia. Compared with healthy parturients, those with severe preeclampsia experience less frequent, less severe spinal-induced hypotension. In severe preeclampsia, spinal anesthesia may cause a higher incidence of hypotension than epidural anesthesia; however, this hypotension is typically easily treated and short lived and has not been linked to clinically significant differences in outcomes. In this review, we describe the advantages and limitations of spinal anesthesia in the setting of severe preeclampsia and the evidence guiding intraoperative hemodynamic management.

[1]  Jesse M. Ehrenfeld,et al.  The Risk and Outcomes of Epidural Hematomas After Perioperative and Obstetric Epidural Catheterization: A Report from the Multicenter Perioperative Outcomes Group Research Consortium , 2013, Anesthesia and analgesia.

[2]  A. Habib A Review of the Impact of Phenylephrine Administration on Maternal Hemodynamics and Maternal and Neonatal Outcomes in Women Undergoing Cesarean Delivery Under Spinal Anesthesia , 2012, Anesthesia and analgesia.

[3]  W. Buhre,et al.  Arterial waveform analysis in anesthesia and critical care , 2011, Current opinion in anaesthesiology.

[4]  M. Crowther,et al.  The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. , 2011, Blood.

[5]  M. Paech,et al.  Faculty Opinions recommendation of Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. , 2011 .

[6]  G. Sutherland,et al.  Maternal Cardiac Dysfunction and Remodeling in Women With Preeclampsia at Term , 2011, Hypertension.

[7]  T. Nokes,et al.  The risk of spinal haematoma following neuraxial anaesthesia or lumbar puncture in thrombocytopenic individuals , 2010, British journal of haematology.

[8]  J. Heit,et al.  Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition) , 2009, Regional Anesthesia & Pain Medicine.

[9]  K. Yoo,et al.  Effects of remifentanil on cardiovascular and bispectral index responses to endotracheal intubation in severe pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia. , 2009, British journal of anaesthesia.

[10]  W. Gogarten Preeclampsia and anaesthesia , 2009, Current opinion in anaesthesiology.

[11]  T. Cook,et al.  Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. , 2009, British journal of anaesthesia.

[12]  A. Pauca Pressure wave analysis is useful to understand the pathophysiology of preeclampsia, but perhaps not the rapid changes during cesarean delivery. , 2008, Anesthesiology.

[13]  R. Dyer,et al.  The role of the anaesthetist in the management of the pre-eclamptic patient , 2007, Current opinion in anaesthesiology.

[14]  S. Thienthong,et al.  Spinal versus epidural anesthesia for cesarean delivery in severe preeclampsia: a prospective randomized, multicenter study. , 2006, Anesthesia and analgesia.

[15]  M. Suresh,et al.  Airway problems in pregnancy , 2005, Critical care medicine.

[16]  A. Santos,et al.  Spinal anesthesia for cesarean delivery in severely preeclamptic women: don't throw out the baby with the bathwater! , 2005, Anesthesia and analgesia.

[17]  J. Ripart,et al.  Spinal Anesthesia-Induced Hypotension: A Risk Comparison Between Patients with Severe Preeclampsia and Healthy Women Undergoing Preterm Cesarean Delivery , 2005, Anesthesia and analgesia.

[18]  K. McGoldrick,et al.  Severe Neurological Complications After Central Neuraxial Blockades in Sweden 1990-1999 , 2005 .

[19]  N. Dahlgren,et al.  Severe Neurological Complications after Central Neuraxial Blockades in Sweden 1990–1999 , 2004, Anesthesiology.

[20]  J. Ripart,et al.  Patients with Severe Preeclampsia Experience Less Hypotension During Spinal Anesthesia for Elective Cesarean Delivery than Healthy Parturients: A Prospective Cohort Comparison , 2003, Anesthesia and analgesia.

[21]  R. Dyer,et al.  Prospective, Randomized Trial Comparing General with Spinal Anesthesia for Cesarean Delivery in Preeclamptic Patients with a Nonreassuring Fetal Heart Trace , 2003, Anesthesiology.

[22]  N. Douglas,et al.  The upper airway in pregnancy and pre-eclampsia. , 2002, American journal of respiratory and critical care medicine.

[23]  R. Johanson,et al.  Haemodynamic, invasive and echocardiographic monitoring in the hypertensive parturient. , 2001, Best practice & research. Clinical obstetrics & gynaecology.

[24]  M. Douglas,et al.  Platelets, the parturient and regional anesthesia , 2001 .

[25]  James J. Walker,et al.  Pre-eclampsia , 2000, The Lancet.

[26]  K. Arheart,et al.  Combined Spinal and Epidural Anesthesia With Low Doses of Intrathecal Bupivacaine in Women With Severe Preeclampsia: A Preliminary Report , 2000, Regional Anesthesia & Pain Medicine.

[27]  R. V. van Schijndel,et al.  LACK OF AGREEMENT BETWEEN CENTRAL VENOUS PRESSURE AND PULMONARY CAPILLARY WEDGE PRESSURE IN PREECLAMPSIA , 2000, Hypertension in pregnancy.

[28]  C. O'Herlihy,et al.  Maternal central hemodynamics in hypertensive disorders of pregnancy. , 1999, Obstetrics and gynecology.

[29]  R. Curry,et al.  Spinal versus epidural anesthesia for cesarean section in severely preeclamptic patients: a retrospective survey. , 1999, Anesthesiology.

[30]  G. Sharwood-Smith,et al.  Regional anaesthesia for caesarean section in severe preeclampsia: spinal anaesthesia is the preferred choice. , 1999, International journal of obstetric anesthesia.

[31]  B. Sibai,et al.  Changes in maternal middle cerebral artery blood flow velocity associated with general anesthesia in severe preeclampsia. , 1999, Anesthesia and analgesia.

[32]  S. Alahuhta,et al.  Maternal and uteroplacental haemodynamic state in pre-eclamptic patients during spinal anaesthesia for Caesarean section. , 1996, British journal of anaesthesia.

[33]  K. Leveno,et al.  Randomized Comparison of General and Regional Anesthesia for Cesarean Delivery in Pregnancies Complicated by Severe Preeclampsia , 1995, Obstetrics and gynecology.

[34]  G. Y. Wong,et al.  Preoperative Antiplatelet Therapy Does Not Increase the Risk of Spinal Hematoma Associated with Regional Anesthesia , 1995, Anesthesia and analgesia.

[35]  L. Leduc,et al.  Coagulation Profile in Severe Preeclampsia , 1992, Obstetrics and gynecology.

[36]  H. Wallenburg,et al.  Central hemodynamic observations in untreated preeclamptic patients. , 1991 .

[37]  H. Wallenburg,et al.  Central Hemodynamic Observations in Untreated Preeclamptic Patients , 1991, Hypertension.

[38]  S. Datta,et al.  Epidural versus combined spinal epidural block for cesarean section , 1988, Acta anaesthesiologica Scandinavica.

[39]  H. Wallenburg,et al.  Hemodynamic measurements in preeclampsia: preliminary observations. , 1984, American journal of obstetrics and gynecology.

[40]  J. Pritchard,et al.  The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. , 1984, American journal of obstetrics and gynecology.

[41]  B. Gutsche,et al.  Minute Ventilation and Oxygen Consumption during Labor with Epidural Analgesia , 1983, Anesthesiology.

[42]  K.,et al.  Sympathoadrenal activity, maternal, fetal, and neonatal responses after epidural anesthesia in the preeclamptic patient. , 1982, American journal of obstetrics and gynecology.

[43]  S. Shnider,et al.  The incidence and neonatal effects of maternal hypotension during epidural anesthesia for cesarean section. , 1982, Anesthesiology.

[44]  A. Hollmen,et al.  Lumbar Epidural Analgesia to Improve Intervillous Blood Flow During Labor in Severe Preeclampsia , 1982, Obstetrics and gynecology.

[45]  H. Ware,et al.  CONTINUOUS SPINAL ANESTHESIA IN THE TREATMENT OF SEVERE PREECLAMPSIA AND ECLAMPSIA , 1952 .

[46]  N. Assali,et al.  Studies on autonomic blockade. I. Comparison between the effects of tetraethylammonium chloride (TEAC) and high selective spinal anesthesia on blood pressure of normal and toxemic pregnancy. , 1950, The Journal of clinical investigation.

[47]  C. Lombard,et al.  Comparison between pulse waveform analysis and thermodilution cardiac output determination in patients with severe pre-eclampsia. , 2011, British journal of anaesthesia.

[48]  E. Jang,et al.  Dose-related attenuation of cardiovascular responses to tracheal intubation by intravenous remifentanil bolus in severe pre-eclamptic patients undergoing Caesarean delivery. , 2011, British journal of anaesthesia.

[49]  Practice Guidelines for Obstetric Anesthesia An Updated Report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia* , 2007 .

[50]  P. Chen,et al.  Intracerebral hemorrhage in pregnancy: Frequency, risk factors, and outcomeBateman BT, Schumacher HC, Bushnell CD, et al (Columbia Univ, New York; Duke Univ Med Ctr, Durham, NC) Neurology 67:424–429, 2006§ , 2007 .

[51]  G. Sharwood-Smith,et al.  Ephedrine requirements are reduced during spinal anaesthesia for caesarean section in preeclampsia. , 2005, International journal of obstetric anesthesia.

[52]  M. Mansor,et al.  Retrospective review of spinal versus epidural anaesthesia for caesarean section in preeclamptic patients. , 2003, International journal of obstetric anesthesia.

[53]  D. Wlody,et al.  Hypertension in pregnancy. , 1992, The New England journal of medicine.