Glycemic control during critical illness

Tight glucose control in the intensive care unit was associated with an improved survival in one pioneering study, but this finding was not confirmed in seven other trials. The reasons underlying this discrepancy are not fully elucidated, indicating that an improved understanding of the physiology and pathophysiology of blood glucose (BG) regulation is needed. Potential reasons for the discrepancies between the studies also include: case-mix, with different optimal BG in different types of patients; hypoglycemia, which is associated with a poor outcome; and the magnitude of glucose variability. Safe and effective glucose control will require progress in the definition of optimal BG, and in the measurement techniques including continuous monitoring insulin algorithms and closed-loop systems.

[1]  G. Van den Berghe,et al.  Early versus Late Parenteral Nutrition in Critically Ill Adults , 2011, The New England journal of medicine.

[2]  C. Mélot,et al.  Mild hypoglycemia is independently associated with increased mortality in the critically ill , 2011, Critical care.

[3]  K. Hanazaki,et al.  The evaluation of the ability of closed-loop glycemic control device to maintain the blood glucose concentration in intensive care unit patients* , 2011, Critical care medicine.

[4]  P. Shekelle,et al.  Use of Intensive Insulin Therapy for the Management of Glycemic Control in Hospitalized Patients: A Clinical Practice Guideline From the American College of Physicians , 2011, Annals of Internal Medicine.

[5]  P. Kalfon,et al.  Glycemic Control in the Intensive Care Unit and during the Postoperative Period , 2011, Anesthesiology.

[6]  I. Mackenzie,et al.  The metrics of glycaemic control in critical care , 2011, Intensive Care Medicine.

[7]  J. Vincent,et al.  Critical illness-induced dysglycaemia: diabetes and beyond , 2010, Critical care.

[8]  N. Adhikari,et al.  Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data , 2010, Critical care.

[9]  J. Preiser,et al.  International recommendations for glucose control in adult non diabetic critically ill patients , 2010, Critical care.

[10]  P. Spronk,et al.  Clinical review: Strict or loose glycemic control in critically ill patients - implementing best available evidence from randomized controlled trials , 2010, Critical care.

[11]  D. Annane,et al.  Tight Glycemic Control in Critically Ill Patients—Reply , 2010 .

[12]  P. Marik,et al.  Original ResearchCritical Care MedicineToward Understanding Tight Glycemic Control in the ICU: A Systematic Review and Metaanalysis , 2010 .

[13]  J. Geoffrey Chase,et al.  What Makes Tight Glycemic Control Tight? The Impact of Variability and Nutrition in Two Clinical Studies , 2010, Journal of diabetes science and technology.

[14]  Michael Bailey,et al.  Hypoglycemia and outcome in critically ill patients. , 2010, Mayo Clinic proceedings.

[15]  J. Vincent.  Blood glucose control in 2010: 110 to 150 mg/dL and minimal variability. , 2010, Critical care medicine.

[16]  D. Annane,et al.  Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. , 2010, JAMA.

[17]  Elie Azoulay,et al.  Selected medical errors in the intensive care unit: results of the IATROREF study: parts I and II. , 2010, American journal of respiratory and critical care medicine.

[18]  H. Lohmann,et al.  Hypoglycemia Aggravates Critical Illness–Induced Neurocognitive Dysfunction , 2009, Diabetes Care.

[19]  Mercedes Falciglia,et al.  Hyperglycemia–related mortality in critically ill patients varies with admission diagnosis* , 2009, Critical care medicine.

[20]  J. L. Messina,et al.  Acute insulin resistance following injury , 2009, Trends in Endocrinology & Metabolism.

[21]  Inna Chervoneva,et al.  Clinical Need for Continuous Glucose Monitoring in the Hospital , 2009, Journal of diabetes science and technology.

[22]  J. Preiser,et al.  An Overview of Hypoglycemia in the Critically Ill , 2009, Journal of diabetes science and technology.

[23]  Johan Groeneveld,et al.  A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study , 2009, Intensive Care Medicine.

[24]  Richard Hellman,et al.  American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. , 2009, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[25]  Deborah J. Cook,et al.  Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data , 2009, Canadian Medical Association Journal.

[26]  Stephane Heritier,et al.  Intensive versus conventional glucose control in critically ill patients. , 2009, The New England journal of medicine.

[27]  J. Preiser,et al.  Glucose Variability in Critically III Patients , 2009 .

[28]  S. Mayer,et al.  Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: A microdialysis study* , 2008, Critical care medicine.

[29]  Ziad A Memish,et al.  Intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical critically ill patients* , 2008, Critical care medicine.

[30]  J. Donado,et al.  Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial , 2008, Critical care.

[31]  J. Preiser,et al.  Moving beyond tight glucose control to safe effective glucose control , 2008, Critical care.

[32]  Brenda G Fahy,et al.  An Analysis: Hyperglycemic Intensive Care Patients Need Continuous Glucose Monitoring—Easier Said than Done , 2008, Journal of diabetes science and technology.

[33]  H. Krumholz,et al.  Glucometrics in Patients Hospitalized With Acute Myocardial Infarction: Defining the Optimal Outcomes-Based Measure of Risk , 2008, Circulation.

[34]  Rolf Rossaint,et al.  Intensive insulin therapy and pentastarch resuscitation in severe sepsis. , 2008, The New England journal of medicine.

[35]  J. Mahoney,et al.  Glucose Measurement: Confounding Issues in Setting Targets for Inpatient Management , 2007, Diabetes Care.

[36]  C. Zauner,et al.  Severity of insulin resistance in critically ill medical patients. , 2007, Metabolism: clinical and experimental.

[37]  Asli Ozdas,et al.  INSULIN RESISTANCE DESPITE TIGHT GLUCOSE CONTROL IS ASSOCIATED WITH MORTALITY IN CRITICALLY ILL SURGICAL PATIENTS.: 44 , 2006 .

[38]  Jaap E Tulleken,et al.  Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients , 2006, Critical care.

[39]  Rinaldo Bellomo,et al.  Variability of Blood Glucose Concentration and Short-term Mortality in Critically Ill Patients , 2006, Anesthesiology.

[40]  Thomas Lotz,et al.  A simple insulin-nutrition protocol for tight glycemic control in critical illness: development and protocol comparison. , 2006, Diabetes technology & therapeutics.

[41]  G. Van den Berghe,et al.  Intensive insulin therapy in the medical ICU. , 2006, The New England journal of medicine.

[42]  P. Coriat,et al.  Poor Intraoperative Blood Glucose Control Is Associated with a Worsened Hospital Outcome after Cardiac Surgery in Diabetic Patients , 2005, Anesthesiology.

[43]  N. Cheung,et al.  Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. , 2005, Diabetes care.

[44]  I. Hirsch,et al.  American College of Endocrinology position statement on inpatient diabetes and metabolic control. , 2004, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[45]  G. Grunkemeier,et al.  Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. , 2003, The Journal of thoracic and cardiovascular surgery.

[46]  B. Bistrian,et al.  Intensive insulin therapy in critically ill patients. , 2002, The New England journal of medicine.

[47]  M Schetz,et al.  Intensive insulin therapy in critically ill patients. , 2001, The New England journal of medicine.

[48]  B. Kahn,et al.  Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. , 1999, The New England journal of medicine.

[49]  O. Ljungqvist,et al.  Insulin resistance: a marker of surgical stress. , 1999, Current opinion in clinical nutrition and metabolic care.

[50]  H. Chandalia,et al.  STRESS HYPERGLYCAEMIA , 1984, The Lancet.