Research Progress on the Pathogenesis of Aortic aneurysm and Dissection in Metabolism.

[1]  Yong Sook Kim,et al.  ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation , 2023, Experimental & Molecular Medicine.

[2]  S. Monier,et al.  High-Density Lipoprotein Alterations in Type 2 Diabetes and Obesity , 2023, Metabolites.

[3]  B. Loeys,et al.  The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and dissection , 2023, European heart journal.

[4]  J. Qian,et al.  Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis , 2023, Frontiers in Cardiovascular Medicine.

[5]  M. Feinberg,et al.  Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis , 2022, Nature Communications.

[6]  Yixuan Zhang,et al.  Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication , 2022, Redox biology.

[7]  K. Node,et al.  Dose-dependent relationship of blood pressure and glycemic status with risk of aortic dissection and aneurysm. , 2022, European journal of preventive cardiology.

[8]  R. Muthupillai,et al.  Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. , 2022, The journals of gerontology. Series A, Biological sciences and medical sciences.

[9]  L. Altucci,et al.  SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency , 2022, Cellular and Molecular Life Sciences.

[10]  Meng Li,et al.  The Role of Amino Acids in Endothelial Biology and Function , 2022, Cells.

[11]  L. Cynober,et al.  Glutamate: A Safe Nutrient, Not Just a Simple Additive , 2022, Annals of Nutrition and Metabolism.

[12]  Xuanyu Liu,et al.  Metabolomic Profile Reveals That Ceramide Metabolic Disturbance Plays an Important Role in Thoracic Aortic Dissection , 2022, Frontiers in Cardiovascular Medicine.

[13]  Ling Zhu,et al.  Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated-M1 Macrophage Polarization-Dependent Vascular Smooth Muscle Cell Phenotypic Conversion , 2022, Oxidative medicine and cellular longevity.

[14]  J. Hou,et al.  Corrigendum: C1q/TNF-Related Protein 9 Attenuates Atherosclerosis by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the AMPKα/KLF4 Signaling Pathway , 2021, Frontiers in Pharmacology.

[15]  M. Bashir,et al.  Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease , 2021, Frontiers in Cardiovascular Medicine.

[16]  H. Schäfers,et al.  Acute Aortic Syndrome Revisited: JACC State-of-the-Art Review. , 2021, Journal of the American College of Cardiology.

[17]  Wei-Chiao Chang,et al.  Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway , 2021, International journal of molecular sciences.

[18]  J. Ket,et al.  The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections , 2021, European journal of clinical investigation.

[19]  Y. E. Chen,et al.  Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. , 2021, European heart journal.

[20]  M. Gladwin Endothelium Seeing Red: Should We Redefine eNOS as the Endothelial and Erythrocytic NOS? , 2021, Circulation.

[21]  Ming Wang,et al.  HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury , 2021, Cellular & molecular biology letters.

[22]  Wenyan Zhao,et al.  The interaction of hypertension and homocysteine increases the risk of mortality among middle-aged and older population in the United States , 2021, Journal of hypertension.

[23]  A. Gu,et al.  HDL cholesterol: A potential mediator of the association between serum levels of a mixture of metals and the risk of aortic dissection in a Chinese population. , 2021, Environmental pollution.

[24]  G. S. Sharma,et al.  Functional inhibition of redox regulated heme proteins: A novel mechanism towards oxidative stress induced by homocysteine , 2021, Redox biology.

[25]  O. Saik,et al.  Glucose Variability: How Does It Work? , 2021, International journal of molecular sciences.

[26]  Yueying Yang,et al.  Macrophage-biomimetic anti-inflammatory liposomes for homing and treating of aortic dissection. , 2021, Journal of controlled release : official journal of the Controlled Release Society.

[27]  B. Zarić,et al.  Tryptophan metabolism in atherosclerosis and diabetes. , 2021, Current medicinal chemistry.

[28]  N. Mendez-Barbero,et al.  Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling , 2021, International journal of molecular sciences.

[29]  Zhi‐Ren Zhang,et al.  Homocysteine Causes Endothelial Dysfunction via Inflammatory Factor-Mediated Activation of Epithelial Sodium Channel (ENaC) , 2021, Frontiers in Cell and Developmental Biology.

[30]  A. von Eckardstein,et al.  The Endothelium Is Both a Target and a Barrier of HDL’s Protective Functions , 2021, Cells.

[31]  S. Bakker,et al.  High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events , 2021, Circulation.

[32]  M. Hayden,et al.  Toll-Like Receptor 4 Mediated Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation in Vascular Smooth Muscle Cells via Src and Sirt1/3 Pathway , 2021, Mediators of inflammation.

[33]  A. Gotto,et al.  High-density lipoproteins, reverse cholesterol transport and atherogenesis , 2021, Nature Reviews Cardiology.

[34]  J. Wells,et al.  Microbial Regulation of Host Physiology by Short-chain Fatty Acids. , 2021, Trends in microbiology.

[35]  Jing Wang,et al.  Advanced Research of Abdominal Aortic Aneurysms on Metabolism , 2021, Frontiers in Cardiovascular Medicine.

[36]  R. Guieu,et al.  Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link? , 2021, International journal of molecular sciences.

[37]  R. Liu,et al.  Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway , 2021, Journal of Advanced Research.

[38]  Kai Cao,et al.  Probucol decreases homocysteine-stimulated CRP production in rat aortic smooth muscle cells via regulating HO-1/NADPH oxidase/ROS/p38 pathway. , 2020, Acta biochimica et biophysica Sinica.

[39]  R. Donkin,et al.  Long Chain Omega-3 Polyunsaturated Fatty Acids Improve Vascular Stiffness in Abdominal Aortic Aneurysm: A Randomized Controlled Trial , 2020, Nutrients.

[40]  Yaling Han,et al.  TRPV5 attenuates abdominal aortic aneurysm in mice by regulating KLF4-dependent phenotype switch of aortic vascular smooth muscle cells. , 2020, Archives of biochemistry and biophysics.

[41]  Yiqing Ye,et al.  The role of short-chain fatty acids in immunity, inflammation and metabolism , 2020, Critical reviews in food science and nutrition.

[42]  P. Skládal,et al.  Myeloperoxidase mediated alteration of endothelial function is dependent on its cationic charge. , 2020, Free radical biology & medicine.

[43]  A. Hekmatdoost,et al.  Dietary ω-3 fatty acids and their influence on inflammation via Toll-like receptor pathways. , 2020, Nutrition.

[44]  Zhongwei Liu,et al.  Toll-like receptor 4 plays a key role in advanced glycation end products-induced M1 macrophage polarization. , 2020, Biochemical and biophysical research communications.

[45]  Gang Xu,et al.  Metabolism of vascular smooth muscle cells in vascular diseases. , 2020, American journal of physiology. Heart and circulatory physiology.

[46]  Dongho Kim,et al.  Taurine chloramine selectively regulates neutrophil degranulation through the inhibition of myeloperoxidase and upregulation of lactoferrin , 2020, Amino Acids.

[47]  J. Liou,et al.  5-methoxytryptophan: an arsenal against vascular injury and inflammation , 2020, Journal of Biomedical Science.

[48]  Yundai Chen,et al.  Bcl‐2‐associated athanogene 5 overexpression attenuates catecholamine‐induced vascular endothelial cell apoptosis , 2020, Journal of cellular physiology.

[49]  G. Guillemin,et al.  Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity , 2020, Frontiers in Neuroscience.

[50]  A. Shore,et al.  Plasma Homocysteine and Cardiovascular Organ Damage in a Population with a High Prevalence of Risk Factors. , 2020, The Journal of clinical endocrinology and metabolism.

[51]  Jian Yang,et al.  Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss , 2020, Journal of pineal research.

[52]  Michael E. Hall,et al.  Obesity, Hypertension, and Cardiac Dysfunction , 2020, Circulation research.

[53]  R. Guéant-Rodriguez,et al.  Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall. , 2020, Biochimie.

[54]  Junhua Wang,et al.  ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4 , 2020, Bioscience reports.

[55]  T. van der Poll,et al.  Platelet Activation and Endothelial Cell Dysfunction. , 2020, Critical care clinics.

[56]  Yan-Hui Peng,et al.  Ox-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated In fl ammasome Activation via Endoplasmic Reticulum Stress , 2020 .

[57]  Yulong Chen,et al.  New insights into phenotypic switching of VSMCs induced by hyperhomocysteinemia: Role of endothelin-1 signaling. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[58]  W. Kong,et al.  Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰ , 2019, EBioMedicine.

[59]  R. Baumgartner,et al.  3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr−/− mice , 2019, Cardiovascular research.

[60]  P. Carmeliet,et al.  Hallmarks of Endothelial Cell Metabolism in Health and Disease. , 2019, Cell metabolism.

[61]  B. Brüne,et al.  Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition , 2019, The EMBO journal.

[62]  Qingzhong Xiao,et al.  Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection , 2019, Pharmaceuticals.

[63]  J. Mehta,et al.  LOX-1: Regulation, Signaling and Its Role in Atherosclerosis , 2019, Antioxidants.

[64]  E. Natour,et al.  Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation. , 2019, Arteriosclerosis, thrombosis, and vascular biology.

[65]  U. Christians,et al.  Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β‐synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial , 2019, Journal of inherited metabolic disease.

[66]  M. Bennett,et al.  Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms , 2019, Arteriosclerosis, thrombosis, and vascular biology.

[67]  Qiang Li,et al.  Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction , 2019, Redox biology.

[68]  Hong Zhang,et al.  Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs , 2019, Oxidative medicine and cellular longevity.

[69]  J. Mehta,et al.  Role of Ox-LDL and LOX-1 in Atherogenesis. , 2019, Current medicinal chemistry.

[70]  R. Castro,et al.  The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art , 2019, International journal of molecular sciences.

[71]  Brian J. Bennett,et al.  Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1 , 2019, The Journal of Immunology.

[72]  W. Hughes,et al.  Vascular autophagy in physiology and pathology. , 2019, American journal of physiology. Heart and circulatory physiology.

[73]  Hong-yu Liu,et al.  Expression of platelet‐derived growth factor B is upregulated in patients with thoracic aortic dissection , 2018, Journal of vascular surgery.

[74]  Chunxiang Zhang,et al.  PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis , 2018, Nature Communications.

[75]  Christine Y. Chuang,et al.  Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase , 2018, Redox biology.

[76]  Tao Zeng,et al.  Cytokines in aortic dissection. , 2018, Clinica chimica acta; international journal of clinical chemistry.

[77]  W. Durante,et al.  Glutaminase‐1 stimulates the proliferation, migration, and survival of human endothelial cells , 2018, Biochemical pharmacology.

[78]  S. de Val,et al.  Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile? , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[79]  Xian Wang,et al.  Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis , 2018, Redox biology.

[80]  Cheuk-Kwan Sun,et al.  Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice , 2018, Journal of pineal research.

[81]  G. Ng,et al.  Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy? , 2018, Microvascular research.

[82]  Sa Shi,et al.  Exogenous hydrogen sulfide protects from endothelial cell damage, platelet activation, and neutrophils extracellular traps formation in hyperhomocysteinemia rats , 2018, Experimental cell research.

[83]  Yulong Chen,et al.  Homocysteine up-regulates ETB receptors via suppression of autophagy in vascular smooth muscle cells. , 2018, Microvascular research.

[84]  Gary Siuzdak,et al.  Metabolomics activity screening for identifying metabolites that modulate phenotype , 2018, Nature Biotechnology.

[85]  M. Bennett,et al.  Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis , 2018, Cardiovascular research.

[86]  Yong Ji,et al.  eNOS S-nitrosylation mediated OxLDL-induced endothelial dysfunction via increasing the interaction of eNOS with β‑catenin. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[87]  De-Pei Liu,et al.  Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo , 2017, Circulation.

[88]  Jianyi(Jay) Zhang,et al.  Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells , 2017, Circulation research.

[89]  P. Carmeliet,et al.  Endothelial Cell Metabolism in Health and Disease. , 2017, Trends in cell biology.

[90]  Y. Jiao,et al.  Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy. , 2017, Molecular medicine reports.

[91]  Enqi Liu,et al.  Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through Sirt1/ERK1/2 signaling pathway. , 2017, Microvascular research.

[92]  H. Jo,et al.  Mechanical Activation of Hypoxia-Inducible Factor 1 alpha Drives Endothelial Dysfunction at Atheroprone Sites , 2022 .

[93]  L. Monti,et al.  Decreased diabetes risk over 9 year after 18-month oral l-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of l-arginine study) , 2017, European Journal of Nutrition.

[94]  Y. M. Lee,et al.  Lactate dehydrogenase-A is indispensable for vascular smooth muscle cell proliferation and migration. , 2017, Biochemical and biophysical research communications.

[95]  P. Elliott,et al.  Isolated aortic root dilation in homocystinuria , 2017, Journal of Inherited Metabolic Disease.

[96]  Ha Won Kim,et al.  Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine. , 2017, American journal of physiology. Heart and circulatory physiology.

[97]  Cholsoon Jang,et al.  Glutamine fuels proliferation but not migration of endothelial cells , 2017, The EMBO journal.

[98]  T. Yan,et al.  Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress , 2017, Oxidative medicine and cellular longevity.

[99]  D. Bernhard,et al.  Metabolomic profiling of ascending thoracic aortic aneurysms and dissections - Implications for pathophysiology and biomarker discovery , 2017, PloS one.

[100]  Y. Wang,et al.  ER stress dependent microparticles derived from smooth muscle cells promote endothelial dysfunction during thoracic aortic aneurysm and dissection , 2017, Clinical science.

[101]  J. Pelisek,et al.  Association of Matrix Metalloproteinase Levels with Collagen Degradation in the Context of Abdominal Aortic Aneurysm. , 2017, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[102]  W. Durante,et al.  Ammonia Promotes Endothelial Cell Survival via the Heme Oxygenase‐1‐Mediated Release of Carbon Monoxide , 2017, Free radical biology & medicine.

[103]  M. Zou,et al.  Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases , 2017, Cellular and Molecular Life Sciences.

[104]  Qilong Wang,et al.  Activation of NAD(P)H Oxidase by Tryptophan-Derived 3-Hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo , 2014, Circulation research.

[105]  F. Loffredo,et al.  C-reactive protein induces expression of matrix metalloproteinase-9: a possible link between inflammation and plaque rupture. , 2013, International journal of cardiology.

[106]  Zhenggang Yang,et al.  Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway , 2012, PloS one.

[107]  W. Ling,et al.  Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1/2 pathway in apoE(-/-) mice. , 2012, Cardiovascular research.

[108]  S. Nagamachi,et al.  Inhibition of Development of Abdominal Aortic Aneurysm by Glycolysis Restriction , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[109]  X. Yuan,et al.  Melatonin inhibits IL‐1β‐induced monolayer permeability of human umbilical vein endothelial cells via Rac activation , 2011, Journal of pineal research.

[110]  W. Durante Protective role of heme oxygenase-1 against inflammation in atherosclerosis. , 2011, Frontiers in bioscience.

[111]  J. Tschopp,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[112]  Wei Li,et al.  Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis. , 2020, Frontiers in bioscience.

[113]  M. Walczewska,et al.  Neutrophils as sentinel cells of the immune system: A role of the MPO-halide-system in innate and adaptive immunity. , 2019, Current medicinal chemistry.

[114]  E. Carneiro,et al.  Modulation of endothelium-derived nitric oxide production and activity by taurine and taurine-conjugated bile acids. , 2019, Nitric oxide : biology and chemistry.

[115]  Fei Xiao,et al.  Intermedin Enlarges the Vascular Lumen by Inducing the Quiescent Endothelial Cell Proliferation , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[116]  P. Carmeliet,et al.  Endothelial Cell Metabolism. , 2018, Physiological reviews.

[117]  C. Szabó Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications. , 2017, American journal of physiology. Cell physiology.