Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid.

[1]  D. Simberg,et al.  C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice , 2020, Frontiers in Immunology.

[2]  C. Reutelingsperger,et al.  Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. , 2019, Kidney international.

[3]  S. Kaveri,et al.  Natural Antibodies: from First-Line Defense Against Pathogens to Perpetual Immune Homeostasis , 2019, Clinical Reviews in Allergy & Immunology.

[4]  B. Tokarz-Deptuła,et al.  Natural antibodies – facts known and unknown , 2018, Central-European journal of immunology.

[5]  T. Arnesen,et al.  Spotlight on protein N-terminal acetylation , 2018, Experimental & Molecular Medicine.

[6]  Junfei Jin,et al.  Natural immunoglobulin M initiates an inflammatory response important for both hepatic ischemia reperfusion injury and regeneration in mice , 2018, Hepatology.

[7]  T. L. Boye,et al.  Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair , 2017, Nature Communications.

[8]  A. M. Hernández,et al.  Defining Natural Antibodies , 2017, Front. Immunol..

[9]  Hong Zhu,et al.  Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement , 2017, Journal of Neuroinflammation.

[10]  P. Krammer,et al.  Life, death and tolerance. , 2017, Biochemical and biophysical research communications.

[11]  M. Reth,et al.  The FcμR Limits Tonic BCR Signaling by Regulating IgM-BCR Expression , 2017, Nature immunology.

[12]  T. Arnesen,et al.  The world of protein acetylation. , 2016, Biochimica et biophysica acta.

[13]  H. Weyd,et al.  More than just innate affairs – on the role of annexins in adaptive immunity , 2016, Biological chemistry.

[14]  T. L. Boye,et al.  Annexins in plasma membrane repair , 2016, Biological chemistry.

[15]  N. Baumgarth B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production , 2016, Front. Immunol..

[16]  Yi Wang,et al.  Annexin A4-nuclear factor-κB feedback circuit regulates cell malignant behavior and tumor growth in gallbladder cancer , 2016, Scientific Reports.

[17]  A. Addlagatta,et al.  Human Naa50 Protein Displays Broad Substrate Specificity for Amino-terminal Acetylation , 2016, The Journal of Biological Chemistry.

[18]  Chang Sun,et al.  The role of annexin A4 in cancer. , 2016, Frontiers in bioscience.

[19]  M. Sun,et al.  Annexin A4 and cancer. , 2015, Clinica chimica acta; international journal of clinical chemistry.

[20]  J. Hughes,et al.  Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes , 2015, PloS one.

[21]  P. Krammer,et al.  The Tolerogenic Function of Annexins on Apoptotic Cells Is Mediated by the Annexin Core Domain , 2015, The Journal of Immunology.

[22]  M. Goddard,et al.  Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion Injury , 2015, Circulation.

[23]  A. Strongin,et al.  Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival. , 2014, Developmental biology.

[24]  B. Pulendran,et al.  Innate Immune Sensing and Response to Influenza , 2014, Current topics in microbiology and immunology.

[25]  Ronen Marmorstein,et al.  Molecular Basis for Amino-Terminal Acetylation by the Heterodimeric NatA Complex , 2013, Nature Structural &Molecular Biology.

[26]  P. Krammer,et al.  Annexin A1 on the Surface of Early Apoptotic Cells Suppresses CD8+ T Cell Immunity , 2013, PloS one.

[27]  V. M. Holers,et al.  Pathogenic Natural Antibodies Propagate Cerebral Injury Following Ischemic Stroke in Mice , 2012, The Journal of Immunology.

[28]  R. Takahashi,et al.  Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. , 2012, Biochimica et biophysica acta.

[29]  A. Cheema,et al.  Small Changes Huge Impact: The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease , 2011, Journal of amino acids.

[30]  T. Arnesen Towards a Functional Understanding of Protein N-Terminal Acetylation , 2011, PLoS biology.

[31]  Yu-Sun Chang,et al.  Detection of Annexin A Autoantibodies in Sera From Colorectal Cancer Patients , 2011, Journal of clinical gastroenterology.

[32]  M. Paulsson,et al.  Identification of Novel Binding Partners (Annexins) for the Cell Death Signal Phosphatidylserine and Definition of Their Recognition Motif* , 2010, The Journal of Biological Chemistry.

[33]  T. Enomoto,et al.  Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary , 2010, Expert opinion on therapeutic targets.

[34]  Emmanuel Baslé,et al.  Protein chemical modification on endogenous amino acids. , 2010, Chemistry & biology.

[35]  Sang J. Chung,et al.  Annexin A4 interacts with the NF-κB p50 subunit and modulates NF-κB transcriptional activity in a Ca2+-dependent manner , 2010, Cellular and Molecular Life Sciences.

[36]  D.G. Knorre,et al.  Chemical and Functional Aspects of Posttranslational Modification of Proteins , 2009, Acta naturae.

[37]  S. Thiel,et al.  Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis1 , 2009, The Journal of Immunology.

[38]  R. Evjenth,et al.  Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans , 2009, Proceedings of the National Academy of Sciences.

[39]  Yong-Beom Park,et al.  IgM Antibodies to Apoptosis-Associated Determinants Recruit C1q and Enhance Dendritic Cell Phagocytosis of Apoptotic Cells1 , 2009, The Journal of Immunology.

[40]  V. M. Holers,et al.  Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury1 , 2009, The Journal of Immunology.

[41]  A. Ochsenbein,et al.  Natural antibodies target virus-antibody complexes to organized lymphoid tissue. , 2008, Autoimmunity reviews.

[42]  G. Cagney,et al.  Annexin-1 and Peptide Derivatives Are Released by Apoptotic Cells and Stimulate Phagocytosis of Apoptotic Neutrophils by Macrophages1 , 2007, The Journal of Immunology.

[43]  C. Schultz,et al.  Annexin A4 self-association modulates general membrane protein mobility in living cells. , 2006, Molecular biology of the cell.

[44]  A. Waheed,et al.  Proteomic characterization of lipid rafts markers from the rat intestinal brush border. , 2006, Biochemical and Biophysical Research Communications - BBRC.

[45]  S. Fleming Natural antibodies, autoantibodies and complement activation in tissue injury , 2006, Autoimmunity.

[46]  S. Shinton,et al.  Evidence of marginal-zone B cell-positive selection in spleen. , 2005, Immunity.

[47]  S. Moss,et al.  Annexins: linking Ca2+ signalling to membrane dynamics , 2005, Nature Reviews Molecular Cell Biology.

[48]  K. Elkon,et al.  IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo , 2005, Autoimmunity.

[49]  M. Walport,et al.  Predominant role of IgM‐dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow‐derived macrophages in vitro , 2005, European journal of immunology.

[50]  J. Iglesias,et al.  Evolutionary perspective on annexin calcium-binding domains. , 2004, Biochimica et biophysica acta.

[51]  L. Matrisian,et al.  Annexins expressed on the cell surface serve as receptors for adhesion to immobilized fetuin-A. , 2004, Biochimica et biophysica acta.

[52]  C. Scharf,et al.  Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. , 2004, Cancer letters.

[53]  Volker Gerke,et al.  Annexins – unique membrane binding proteins with diverse functions , 2004, Journal of Cell Science.

[54]  H. Daniel,et al.  Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis , 2004, International journal of cancer.

[55]  H. Ohkawa,et al.  Augmentation of ethanol-induced cell damage and activation of nuclear factor-kappa B by annexin IV in cultured cells. , 2003, Alcoholism, clinical and experimental research.

[56]  B. Kishore,et al.  Annexin A4 Reduces Water and Proton Permeability of Model Membranes but Does Not Alter Aquaporin 2–mediated Water Transport in Isolated Endosomes , 2003, The Journal of general physiology.

[57]  Swathi Arur,et al.  Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. , 2003, Developmental cell.

[58]  H. Ohkawa,et al.  Ethanol-induced augmentation of annexin IV in cultured cells and the enhancement of cytotoxicity by overexpression of annexin IV by ethanol. , 2002, Biochimica et biophysica acta.

[59]  S. Julien,et al.  B Cell Positive Selection by Soluble Self-Antigen1 , 2002, The Journal of Immunology.

[60]  H. Ohkawa,et al.  Ethanol-induced augmentation of annexin IV expression in rat C6 glioma and human A549 adenocarcinoma cells. , 2002, Alcoholism, clinical and experimental research.

[61]  K. Massé,et al.  Annexin IV (Xanx-4) has a functional role in the formation of pronephric tubules. , 2002, Development.

[62]  H. Ohkawa,et al.  Alteration of annexin IV expression in alcoholics. , 2001, Alcoholism, clinical and experimental research.

[63]  J. Kearney,et al.  B1 cells: similarities and differences with other B cell subsets. , 2001, Current opinion in immunology.

[64]  R M Zinkernagel,et al.  Natural antibodies and complement link innate and acquired immunity. , 2000, Immunology today.

[65]  N. Collins,et al.  Modulation of paclitaxel resistance by annexin IV in human cancer cell lines , 2000, British Journal of Cancer.

[66]  J. Silver,et al.  Positive selection of natural autoreactive B cells. , 1999, Science.

[67]  Ralph A. Bradshaw,et al.  N-Terminal processing: the methionine aminopeptidase and Nα-acetyl transferase families , 1998 .

[68]  N. Mayran,et al.  Polarized localizations of annexins I, II, VI and XIII in epithelial cells of intestinal, hepatic and pancreatic tissues. , 1998, Journal of cell science.

[69]  A. Coutinho,et al.  The repertoire of serum IgM in normal mice is largely independent of external antigenic contact , 1997, European journal of immunology.

[70]  N. Mayran,et al.  Cellular and subcellular localizations of annexins I, IV, and VI in lung epithelia. , 1996, The American journal of physiology.

[71]  T. Tsuruo,et al.  Expression of carbohydrate-binding protein p33/41 in human tumor cell lines. , 1996, Journal of biochemistry.

[72]  T. Yeatman,et al.  Extracellular annexin VI expression is associated with divalent cation-dependent endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells. , 1994, Experimental cell research.

[73]  P. Uhrin,et al.  Annexin VI isoforms are differentially expressed in mammalian tissues. , 1994, Biochimica et biophysica acta.

[74]  W. Dubinsky,et al.  A role for annexin IV in epithelial cell function. Inhibition of calcium-activated chloride conductance. , 1994, The Journal of biological chemistry.

[75]  N. Baumgarth The double life of a B-1 cell: self-reactivity selects for protective effector functions , 2011, Nature Reviews Immunology.

[76]  T. Yeatman,et al.  Expression of annexins on the surfaces of non-metastatic and metastatic human and rodent tumor cells , 2004, Clinical & Experimental Metastasis.

[77]  A. Coutinho,et al.  Natural autoantibodies. , 1995, Current opinion in immunology.

[78]  A. Rigal,et al.  Cellular and subcellular localization of annexin IV in rabbit intestinal epithelium, pancreas and liver , 1991, Biology of the cell.