It is found that hydrolytic degradation of large sized devices made of poly(lactic acid) stereocopolymers can lead to morphology changes with partial crystallization of degradation byproducts or residues, provided rather long poly(L-LA) (or poly(D-LA) or both) sequences are initially present in polymer chains. In poly(L-LA) or poly(D-LA)-rich polymers, cristallization of stereoregular sequences prevails either for the whole mass or only for the surface part of the hollow structure