Reverse genetics identifies proteins regulating lipid droplet biogenesis via amphipathic helices
暂无分享,去创建一个
[1] Shugo Nakamura,et al. Multiple genes evolved for fungal septal pore plugging identified via large-scale localization and functional screenings , 2022, bioRxiv.
[2] J. Teng,et al. EI24 promotes cell adaption to ER stress by coordinating IRE1 signaling and calcium homeostasis , 2022, EMBO reports.
[3] S. Ovchinnikov,et al. ColabFold: making protein folding accessible to all , 2022, Nature Methods.
[4] S. Dzurendová,et al. Mucoromycota fungi as powerful cell factories for modern biorefinery , 2021, Applied microbiology and biotechnology.
[5] Y. Ohsaki,et al. Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner , 2020, The Journal of cell biology.
[6] L. Wakim,et al. Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response , 2020, Nature Communications.
[7] G. Moreno-Hagelsieb,et al. Progress in quickly finding orthologs as reciprocal best hits: comparing blast, last, diamond and MMseqs2 , 2020, BMC genomics.
[8] M. Sweet,et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense , 2020, Science.
[9] J. Swanson,et al. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. , 2020, Developmental cell.
[10] P. Juvvadi,et al. Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors , 2020, Antimicrobial Agents and Chemotherapy.
[11] Jacob L. Steenwyk,et al. Genome-scale phylogeny and contrasting modes of genome evolution in the fungal phylum Ascomycota , 2020, Science Advances.
[12] R. Schneiter,et al. Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis , 2020, bioRxiv.
[13] A. Thiam,et al. Neutral lipids regulate amphipathic helix affinity for model lipid droplets , 2020, The Journal of cell biology.
[14] Shugo Nakamura,et al. A novel Pezizomycotina‐specific protein with gelsolin domains regulates contractile actin ring assembly and constriction in perforated septum formation , 2020, Molecular microbiology.
[15] B. Trost,et al. Lipid droplets can promote drug accumulation and activation , 2019, Nature Chemical Biology.
[16] N. Turner,et al. ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets , 2019, The Journal of cell biology.
[17] T. Gabaldón,et al. Fungal evolution: major ecological adaptations and evolutionary transitions , 2019, Biological reviews of the Cambridge Philosophical Society.
[18] L. Nagy,et al. Comparative genomics reveals the origin of fungal hyphae and multicellularity , 2019, Nature Communications.
[19] J. Olzmann,et al. Dynamics and functions of lipid droplets , 2018, Nature Reviews Molecular Cell Biology.
[20] A. Salamov,et al. Leveraging single-cell genomics to expand the fungal tree of life , 2018, Nature Microbiology.
[21] L. Cowen,et al. Antifungal drug resistance: evolution, mechanisms and impact. , 2018, Current opinion in microbiology.
[22] Joshua E. Elias,et al. Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors , 2018, Proceedings of the National Academy of Sciences.
[23] W. Prinz,et al. Lipid droplet and peroxisome biogenesis occur at the same ER subdomains , 2018, Nature Communications.
[24] Anete Romanauska,et al. The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets , 2018, Cell.
[25] B. Antonny,et al. A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets , 2018, Nature Communications.
[26] N. Afseth,et al. High-throughput screening of Mucoromycota fungi for production of low- and high-value lipids , 2018, Biotechnology for Biofuels.
[27] G. Hummer,et al. The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1 , 2018, bioRxiv.
[28] Robert V Farese,et al. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. , 2018, Developmental cell.
[29] Robert V Farese,et al. Lipid Droplet Biogenesis. , 2017, Annual review of cell and developmental biology.
[30] Tu Anh Nguyen,et al. Innovation and constraint leading to complex multicellularity in the Ascomycota , 2017, Nature Communications.
[31] M. Simon,et al. BODIPY 493/503 Staining of Neutral Lipid Droplets for Microscopy and Quantification by Flow Cytometry. , 2016, Bio-protocol.
[32] Sudhir Kumar,et al. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. , 2016, Molecular biology and evolution.
[33] V. Saudek,et al. Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3 , 2016, The Journal of Biological Chemistry.
[34] Judith Klein-Seetharaman,et al. The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix , 2015, eLife.
[35] W. Prinz,et al. A conserved family of proteins facilitates nascent lipid droplet budding from the ER , 2022 .
[36] Robert V Farese,et al. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. , 2015, Developmental cell.
[37] M. Welte. Expanding Roles for Lipid Droplets , 2015, Current Biology.
[38] Michael J E Sternberg,et al. The Phyre2 web portal for protein modeling, prediction and analysis , 2015, Nature Protocols.
[39] T. Reynolds,et al. Candida albicans OPI1 Regulates Filamentous Growth and Virulence in Vaginal Infections, but Not Inositol Biosynthesis , 2015, PloS one.
[40] Antonis Rokas,et al. The Evolution of Fungal Metabolic Pathways , 2014, PLoS genetics.
[41] G. Moreno-Hagelsieb,et al. Quickly Finding Orthologs as Reciprocal Best Hits with BLAT, LAST, and UBLAST: How Much Do We Miss? , 2014, PloS one.
[42] Robert V Farese,et al. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation[S] , 2014, Journal of Lipid Research.
[43] S. Kohlwein,et al. Lipid droplet autophagy in the yeast Saccharomyces cerevisiae , 2014, Molecular biology of the cell.
[44] Shaojie Li,et al. Transcription Factor CCG-8 as a New Regulator in the Adaptation to Antifungal Azole Stress , 2013, Antimicrobial Agents and Chemotherapy.
[45] Ane Markina-Iñarrairaegui,et al. The Aspergillus nidulans Peripheral ER: Disorganization by ER Stress and Persistence during Mitosis , 2013, PloS one.
[46] Bruno Antonny,et al. Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity. , 2012, Developmental cell.
[47] Kevin W Eliceiri,et al. NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.
[48] R. Cornell,et al. The amphipathic helix of an enzyme that regulates phosphatidylcholine synthesis remodels membranes into highly curved nanotubules. , 2012, Biochimica et biophysica acta.
[49] R. Schneiter,et al. Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae , 2011, Journal of Cell Science.
[50] K. Kitamoto,et al. Targeted gene disruption in Koji mold Aspergillus oryzae. , 2011, Methods in molecular biology.
[51] P. Cresswell,et al. The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic α-helix , 2009, Proceedings of the National Academy of Sciences.
[52] Brigitte Cambon,et al. Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118 , 2009, Proceedings of the National Academy of Sciences.
[53] M. Tomita,et al. Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs , 2009, Proceedings of the National Academy of Sciences.
[54] R. Fukuda,et al. Yas3p, an Opi1 Family Transcription Factor, Regulates Cytochrome P450 Expression in Response to n-Alkanes in Yarrowia lipolytica* , 2009, Journal of Biological Chemistry.
[55] S. Osmani,et al. The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex. , 2008, Molecular biology of the cell.
[56] Dominique Douguet,et al. HELIQUEST: a web server to screen sequences with specific alpha-helical properties , 2008, Bioinform..
[57] Robert V Farese,et al. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization , 2008, Nature.
[58] R. Parton,et al. Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast , 2008, The Journal of cell biology.
[59] Richard G. W. Anderson,et al. The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology , 2007, Proceedings of the National Academy of Sciences.
[60] D. Ussery,et al. Comparison of protein coding gene contents of the fungal phyla Pezizomycotina and Saccharomycotina , 2007, BMC Genomics.
[61] Elysa B. Goldberg,et al. Adipocyte differentiation‐related protein reduces lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover , 2007, Journal of lipid research.
[62] D. Small,et al. Apolipoprotein B is conformationally flexible but anchored at a triolein/water interface: a possible model for lipoprotein surfaces. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[63] W. Nierman,et al. Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole , 2006, Current Genetics.
[64] A. Repenning,et al. Constitutive expression of yeast phospholipid biosynthetic genes by variants of Ino2 activator defective for interaction with Opi1 repressor , 2005, Molecular microbiology.
[65] Christopher J. R. Loewen,et al. Phospholipid Metabolism Regulated by a Transcription Factor Sensing Phosphatidic Acid , 2004, Science.
[66] C. Stoeckert,et al. OrthoMCL: identification of ortholog groups for eukaryotic genomes. , 2003, Genome research.
[67] Julie D Thompson,et al. Multiple Sequence Alignment Using ClustalW and ClustalX , 2003, Current protocols in bioinformatics.
[68] L. Pedersen,et al. Structure and function of sulfotransferases. , 2001, Archives of biochemistry and biophysics.
[69] A. Kimmel,et al. Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis* , 2000, The Journal of Biological Chemistry.
[70] J Schultz,et al. SMART, a simple modular architecture research tool: identification of signaling domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[71] J. Hamer,et al. hyp loci control cell pattern formation in the vegetative mycelium of Aspergillus nidulans. , 1998, Genetics.
[72] R. Fischer,et al. Nuclear traffic in fungal hyphae: in vivo study of nuclear migration and positioning in Aspergillus nidulans , 1997, Molecular microbiology.
[73] L Regan,et al. Speeding up protein folding: mutations that increase the rate at which Rop folds and unfolds by over four orders of magnitude. , 1997, Folding & design.
[74] J. Cashman,et al. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. , 1994, Archives of biochemistry and biophysics.
[75] S. Fowler,et al. Nile red: a selective fluorescent stain for intracellular lipid droplets , 1985, The Journal of cell biology.
[76] David Eisenberg,et al. The helical hydrophobic moment: a measure of the amphiphilicity of a helix , 1982, Nature.
[77] A. Stoppani,et al. Pyruvate metabolism in Saccharomyces cerevisiae. , 1951, Nature.