Nuclear Factor I‐C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration

Knockout studies of the murine Nuclear Factor I‐C (NFI‐C) transcription factor revealed abnormal skin wound healing and growth of its appendages, suggesting a role in controlling cell proliferation in adult regenerative processes. Liver regeneration following partial hepatectomy (PH) is a well‐established regenerative model whereby changes elicited in hepatocytes lead to their rapid and phased proliferation. Although NFI‐C is highly expressed in the liver, no hepatic function was yet established for this transcription factor. This study aimed to determine whether NFI‐C may play a role in hepatocyte proliferation and liver regeneration.

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