Design, synthesis and antitumor activity evaluation of 2,4,6-trisubstituted quinazoline derivatives containing piperidine moiety

[1]  Q. Saquib,et al.  Antiviral activity of some benzo[g]quinazolines against coxsackievirus B4: biological screening and docking study , 2023, Pharmacological Reports.

[2]  Peijia Li,et al.  Design, synthesis, crystal structure, and antimicrobial activities of new quinazoline derivatives containing both the sulfonate ester and piperidinylamide moieties. , 2023, Pest management science.

[3]  N. Nagesh,et al.  Synthesis and biological evaluation of 1-phenyl-4,6-dihydrobenzo[b]pyrazolo[3,4-d]azepin-5(1H)-one/thiones as anticancer agents. , 2023, Bioorganic chemistry.

[4]  H. Bahmad,et al.  Anti-Cancer Stem-Cell-Targeted Therapies in Prostate Cancer , 2023, Cancers.

[5]  Ashish S Kothari,et al.  Immunotherapies in rare cancers , 2023, Molecular Cancer.

[6]  G. Hasan,et al.  A review on regulation of cell cycle by extracellular matrix. , 2023, International journal of biological macromolecules.

[7]  P. Dorovatovskii,et al.  The IMDAV Approach Towards Thieno- and Furoisoindolo[2,1-a]Quinazolines-11(13)-Carboxylic Acids Possessing Antimicrobial and Antiviral Activities , 2022, SSRN Electronic Journal.

[8]  J. G. Glade Bender,et al.  Progress in precision therapy in pediatric oncology , 2022, Current opinion in pediatrics.

[9]  Yi-Chia Wang,et al.  Development of novel nitric oxide-releasing quinolinedione/furoxan hybrids as NQO1 inhibitors for intervention of drug-resistanthepatocellular cancer. , 2022, Bioorganic chemistry.

[10]  Lei Zhang,et al.  Discovery of Novel Quinazoline Derivatives as Potent Antitumor Agents , 2022, Molecules.

[11]  D. Trisciuoglio,et al.  Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. , 2022, European journal of medicinal chemistry.

[12]  R. Al-Salahi,et al.  An overview of triazoloquinazolines: Pharmacological significance and recent developments. , 2021, Bioorganic chemistry.

[13]  Yu Ke,et al.  Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives. , 2021, Bioorganic & medicinal chemistry letters.

[14]  Yu Ke,et al.  Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway. , 2021, Bioorganic & medicinal chemistry.

[15]  A. Waszkielewicz,et al.  MH-76, a Novel Non-Quinazoline α1-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats , 2021, Pharmaceuticals.

[16]  M. Ragheb,et al.  Needs and Self-Care Efficacy for Cancer Patients Suffering from Side Effects of Chemotherapy , 2021, Journal of oncology.

[17]  T. Fujita,et al.  Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs , 2021, Pharmaceutics.

[18]  Xiaowei Qin,et al.  Induction of Pyroptosis: A Promising Strategy for Cancer Treatment , 2021, Frontiers in Oncology.

[19]  A. Saeed,et al.  Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances , 2021, Frontiers in Chemistry.

[20]  A. O’Connor,et al.  Gastrointestinal side effects of cancer treatments , 2020, Therapeutic advances in chronic disease.

[21]  R. Bansal,et al.  Therapeutic progression of quinazolines as targeted chemotherapeutic agents. , 2020, European journal of medicinal chemistry.

[22]  Ginson George,et al.  Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids , 2020, RSC advances.

[23]  A. Tiwari,et al.  Amide Bond Bioisosteres: Strategies, Synthesis and Successes. , 2020, Journal of medicinal chemistry.

[24]  M. Cheng,et al.  Design, synthesis and biological evaluation of tetrahydroquinoline-based reversible LSD1 inhibitors. , 2020, European journal of medicinal chemistry.

[25]  Lehui Lu,et al.  Targeted Engineering of Medicinal Chemistry for Cancer Therapy: Recent Advances and Perspectives. , 2020, Angewandte Chemie.

[26]  S. Minucci,et al.  Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. , 2020, ACS medicinal chemistry letters.

[27]  Amit B. Patel.  Investigation of the antibacterial activity of new quinazoline derivatives against methicillin and quinolone resistant Staphylococcus aureus , 2020 .

[28]  Hong-min Liu,et al.  2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K. , 2019, European journal of medicinal chemistry.

[29]  J. Subramanian,et al.  Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer harboring uncommon EGFR mutations: Focus on afatinib. , 2019, Seminars in oncology.

[30]  Linlin Yang,et al.  Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors. , 2019, European journal of medicinal chemistry.

[31]  E. Sousa,et al.  Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects , 2019, Molecules.

[32]  Quentin Liu,et al.  Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors. , 2018, European journal of medicinal chemistry.

[33]  V. Namasivayam,et al.  2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2. , 2018, Journal of medicinal chemistry.

[34]  Tianfeng Chen,et al.  Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to achieve precise cancer therapy , 2018, Drug delivery.

[35]  J. How,et al.  Pulsatile Erlotinib in EGFR‐Positive Non–Small‐Cell Lung Cancer Patients With Leptomeningeal and Brain Metastases: Review of the Literature , 2017, Clinical lung cancer.

[36]  Huijun Sun,et al.  Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines. , 2017, Bioorganic & medicinal chemistry.

[37]  Pengfei Zhang,et al.  Synthesis of Benzimidazo[1,2-c]quinazolines via Metal-Free Intramolecular C–H Amination Reaction , 2016 .

[38]  L. Khawli,et al.  Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development , 2015, mAbs.

[39]  Jie Tang,et al.  Design, Synthesis and Biological Activity Evaluation of 2-Mercapto-4(3H)-quinazolinone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B. , 2012 .

[40]  F. Cappuzzo,et al.  Gefitinib as first-line treatment for patients with advanced non-small-cell lung cancer with activating epidermal growth factor receptor mutation: Review of the evidence. , 2011, Lung cancer.