Relation of contraversive turning to unilateral release of dopamine from the nigrostriatal pathway in rats.

Abstract In order to elucidate the functional role of the dopamine-containing nigrostriatal pathway, bipolar tungsten electrodes were implanted in the region of the substantia nigra and somewhat rostral to it. Stimulation with 100-Hz, 0.5-msec pulses in the medial part of the substantia nigra and the region medial to it elicited contraversive turning behavior. Turning, however, showed rapid fatigue with continued stimulation. Similar turning behavior could be seen with electrodes placed at a point anterior to the substantia nigra on the route probably followed by the nigrostriatal axons. When these electrode tips were used to make electrolytic lesions, the dopamine content of the caudate nucleus on the same side was reduced. If such animals were treated with methylamphetamine they showed a marked tendency to turn toward the side of the lesion These results are consistent with the hypothesis that unilateral activation of the dopamine-containing nigrostriatal pathway results in turning away from the activated side.

[1]  T. Hökfelt,et al.  Evidence for dopamine receptor stimulation by apomorphine , 1967, The Journal of pharmacy and pharmacology.

[2]  T. Hökfelt,et al.  Electron and fluorescence microscopical studies on the nucleus caudatus putamen of the rat after unilateral lesions of ascending nigro-neostriatal dopamine neurons. , 1969, Acta physiologica Scandinavica.

[3]  J. Hyde,et al.  Coordinated eye and body movements evoked by brainstem stimulation in decerebrated cats. , 1958, Journal of neurophysiology.

[4]  K. Fuxe,et al.  Functional role of the nigro-neostriatal dopamine neurons. , 2009, Acta pharmacologica et toxicologica.

[5]  K. Fuxe,et al.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. , 1964, Acta physiologica Scandinavica. Supplementum.

[6]  G LUNDIN,et al.  SOLUBILITY OF ACETYLENE IN LUNG TISSUE AS AN ERROR IN CARDIAC OUTPUT DETERMINATION WITH THE ACETYLENE METHOD. , 1963, Acta physiologica Scandinavica.

[7]  C J CLEMEDSON,et al.  DYNAMIC RESPONSE OF CHEST WALL AND LUNG INJURIES IN RABBITS EXPOSED TO AIR SHOCK WAVES OF SHORT DURATION. , 1964, Acta physiologica Scandinavica. Supplementum.

[8]  R. White,et al.  Circus movements and excitation of striatal and mesodiencephalic centers in rabbits. , 1957, Journal of neurophysiology.

[9]  J. Hyde.  EFFECTS OF SIMULTANEOUS APPLICATION OF OPPOSING STIMULI FOR HEAD TURNING IN CATS. , 1965, Experimental neurology.

[10]  T L Sourkes,et al.  Striatal amines, experimental tremor and the effect of harmaline in the monkey. , 1966, Brain : a journal of neurology.

[11]  T. Sourkes,et al.  INFLUENCE OF THE SUBSTANTIA NIGRA ON THE CATECHOLAMINE CONTENT OF THE STRIATUM. , 1965, Brain : a journal of neurology.

[12]  Skultety Fm.  Circus movements in cats following midbrain stimulation through chronically implanted electrodes. , 1962 .

[13]  K. Fuxe,et al.  FURTHER EVIDENCE FOR THE PRESENCE OF NIGRO-NEOSTRIATAL DOPAMINE NEURONS IN THE RAT. , 1965, The American journal of anatomy.

[14]  P. Feltz,et al.  Properties of caudate unitary responses to repetitive nigral stimulation. , 1969, Brain research.

[15]  J. Delgado.  Sequential Behavior Induced Repeatedly by Stimulation of the Red Nucleus in Free Monkeys , 1965, Science.

[16]  C. Vierck,et al.  Forced Movement Resulting from Midbrain Stimulation in the Rat , 1968 .

[17]  N. Andén.  ON THE FUNCTION OF THE NIGRO-NEOSTRIATAL DOPAMINE PATHWAY , 1966 .

[18]  G. Thieme,et al.  FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE , 1962 .

[19]  T. Sourkes,et al.  Effect of amine precursors on the concentration of striatal dopamine and serotonin in cats with and without unilateral brain stem lesions. , 1967, Brain research.