Model for the dynamics of a spherical bubble undergoing small shape oscillations between parallel soft elastic layers.

A model is developed for a pulsating and translating gas bubble immersed in liquid in a channel formed by two soft, thin elastic parallel layers having densities equal to that of the surrounding liquid and small, but finite, shear moduli. The bubble is nominally spherical but free to undergo small shape deformations. Shear strain in the elastic layers is estimated in a way which is valid for short, transient excitations of the system. Coupled nonlinear second-order differential equations are obtained for the shape and position of the bubble, and numerical integration of an expression for the liquid velocity at the layer interfaces yields an estimate of the elastic layer displacement. Numerical integration of the dynamical equations reveals behavior consistent with laboratory observations of acoustically excited bubbles in ex vivo vessels reported by Chen et al. [Phys. Rev. Lett. 106, 034301 (2011) and Ultrasound Med. Biol. 37, 2139-2148 (2011)].

[1]  John R. Blake,et al.  Cavitation Bubbles Near Boundaries , 1987 .

[2]  Mark F Hamilton,et al.  Modifications of the equation for gas bubble dynamics in a soft elastic medium. , 2005, The Journal of the Acoustical Society of America.

[3]  Katherine W Ferrara,et al.  Acoustic response of compliable microvessels containing ultrasound contrast agents , 2006, Physics in medicine and biology.

[4]  C. Hsiao,et al.  Three-dimensional modeling of the dynamics of therapeutic ultrasound contrast agents. , 2010, Ultrasound in medicine & biology.

[5]  Todd A. Hay,et al.  Model for bubble pulsation in liquid between parallel viscoelastic layers. , 2012, The Journal of the Acoustical Society of America.

[6]  J. Blake,et al.  Transient cavities near boundaries. Part 1. Rigid boundary , 1986, Journal of Fluid Mechanics.

[7]  M. Hamilton,et al.  Bubble interaction dynamics in Lagrangian and Hamiltonian mechanics. , 2007, The Journal of the Acoustical Society of America.

[8]  T. Ye,et al.  Microbubble expansion in a flexible tube. , 2006, Journal of biomechanical engineering.

[9]  Paul A Dayton,et al.  Modeling of nonlinear viscous stress in encapsulating shells of lipid-coated contrast agent microbubbles. , 2009, Ultrasonics.

[10]  Ayache Bouakaz,et al.  Theoretical investigation of shear stress generated by a contrast microbubble on the cell membrane as a mechanism for sonoporation. , 2010, The Journal of the Acoustical Society of America.

[11]  Detlef Lohse,et al.  A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture , 2005 .

[12]  Detlef Lohse,et al.  Single bubble sonoluminescence , 2002 .

[13]  Qian Wang,et al.  Nonlinear interaction between gas bubble and free surface , 1996 .

[14]  K. Hynynen,et al.  Forced linear oscillations of microbubbles in blood capillaries. , 2004, The Journal of the Acoustical Society of America.

[15]  Georges L. Chahine,et al.  Interaction Between an Oscillating Bubble and a Free Surface , 1977 .

[16]  Ayache Bouakaz,et al.  Acoustic response from a bubble pulsating near a fluid layer of finite density and thickness. , 2011, The Journal of the Acoustical Society of America.

[17]  J. Blake,et al.  Growth and collapse of a vapour cavity near a free surface , 1981, Journal of Fluid Mechanics.

[18]  J. Freund,et al.  Suppression of shocked-bubble expansion due to tissue confinement with application to shock-wave lithotripsy. , 2008, The Journal of the Acoustical Society of America.

[19]  L. Rayleigh VIII. On the pressure developed in a liquid during the collapse of a spherical cavity , 1917 .

[20]  Ayache Bouakaz,et al.  Acoustic scattering from a contrast agent microbubble near an elastic wall of finite thickness , 2011, Physics in medicine and biology.

[21]  Wayne Kreider,et al.  Blood vessel deformations on microsecond time scales by ultrasonic cavitation. , 2011, Physical review letters.

[22]  Kester Nahen,et al.  Dynamics of laser-induced cavitation bubbles near an elastic boundary , 2001, Journal of Fluid Mechanics.

[23]  Evert Klaseboer,et al.  Numerical analysis of a gas bubble near bio-materials in an ultrasound field. , 2006, Ultrasound in medicine & biology.

[24]  Gunnar Taraldsen,et al.  A note on reflection of spherical waves. , 2005, The Journal of the Acoustical Society of America.

[25]  Andrea Prosperetti,et al.  The natural frequency of oscillation of gas bubbles in tubes , 1998 .

[26]  S. Emelianov,et al.  Nonlinear dynamics of a gas bubble in an incompressible elastic medium. , 2004, The Journal of the Acoustical Society of America.

[27]  Dominique Legendre,et al.  The viscous drag force on a spherical bubble with a time-dependent radius , 1998 .

[28]  A. Szeri,et al.  Coupled dynamics of translation and collapse of acoustically driven microbubbles. , 2002, The Journal of the Acoustical Society of America.

[29]  Alexander A. Doinikov Translational motion of a bubble undergoing shape oscillations , 2004, Journal of Fluid Mechanics.

[30]  Katherine W. Ferrara,et al.  The natural frequency of nonlinear oscillation of ultrasound contrast agents in microvessels. , 2007, Ultrasound in medicine & biology.

[31]  Kishan Dholakia,et al.  Membrane disruption by optically controlled microbubble cavitation , 2005 .

[32]  Yuantai Hu,et al.  Asymmetric oscillation of cavitation bubbles in a microvessel and its implications upon mechanisms of clinical vessel injury in shock-wave lithotripsy , 2005 .

[33]  Todd A. Hay,et al.  Model of coupled pulsation and translation of a gas bubble and rigid particle. , 2009, The Journal of the Acoustical Society of America.

[34]  Wayne Kreider,et al.  Observations of translation and jetting of ultrasound-activated microbubbles in mesenteric microvessels. , 2011, Ultrasound in medicine & biology.

[35]  W. Lauterborn,et al.  Experimental investigations of cavitation-bubble collapse in the neighbourhood of a solid boundary , 1975, Journal of Fluid Mechanics.

[36]  Todd A. Hay,et al.  Model for the dynamics of two interacting axisymmetric spherical bubbles undergoing small shape oscillations. , 2011, The Journal of the Acoustical Society of America.

[37]  Koichi Ogawa,et al.  Induction of cell-membrane porosity by ultrasound , 1999, The Lancet.

[38]  K. Yasui Single-bubble sonoluminescence from noble gases. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[39]  P. Marmottant,et al.  Controlled vesicle deformation and lysis by single oscillating bubbles , 2003, Nature.

[40]  Paul A Dayton,et al.  Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall. , 2007, The Journal of the Acoustical Society of America.