Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers
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N. Rosen | A. Hsieh | B. Carver | C. Sawyers | E. de Stanchina | Guotai Xu | Yu Chen | Q. Chang | Dan Li | Zeda Zhang | Young Sun Lee | Danielle Choi | Xiaoping Chen | Hsuan-An Chen | S. Haywood | Cindy J Lee | Ninghui Mao | Aura C. Agudelo Rivera
[1] Vianne R. Gao,et al. Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer , 2020, Cancer cell.
[2] C. Mason,et al. Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation , 2020, Cancer cell.
[3] Yeon-Hee Park,et al. Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[4] H. Rugo,et al. Alpelisib for PIK3CA‐Mutated, Hormone Receptor–Positive Advanced Breast Cancer , 2019, The New England journal of medicine.
[5] Yi Mi Wu,et al. Genomic correlates of clinical outcome in advanced prostate cancer , 2019, Proceedings of the National Academy of Sciences.
[6] A. Zelenetz,et al. Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] Roman Schefzik,et al. IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer , 2018, Cell Death & Disease.
[8] A. Font,et al. Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss , 2018, Clinical Cancer Research.
[9] M. Rubin,et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors , 2018, Nature.
[10] Steven J. M. Jones,et al. Oncogenic Signaling Pathways in The Cancer Genome Atlas. , 2018, Cell.
[11] Dejan Juric,et al. Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] J. Barrett,et al. A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA-Mutated Breast and Gynecologic Cancers , 2017, Clinical Cancer Research.
[13] M. Espié,et al. Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. , 2017, The Lancet. Oncology.
[14] Lewis C. Cantley,et al. The PI3K Pathway in Human Disease , 2017, Cell.
[15] A. Armstrong,et al. Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer. , 2017, European journal of cancer.
[16] Maurizio Scaltriti,et al. PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D , 2017, Science.
[17] Jeffrey A Jones,et al. Efficacy and safety of idelalisib in combination with ofatumumab for previously treated chronic lymphocytic leukaemia: an open-label, randomised phase 3 trial. , 2017, The Lancet. Haematology.
[18] I. Treilleux,et al. Phase II study of the PI3K inhibitor BKM120 in patients with advanced or recurrent endometrial carcinoma: a stratified type I–type II study from the GINECO group , 2017, British Journal of Cancer.
[19] M. Rubin,et al. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer , 2017, Science.
[20] K. Cornille,et al. Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition , 2016, Breast Cancer Research.
[21] S. Larson,et al. Everolimus combined with gefitinib in patients with metastatic castration‐resistant prostate cancer: Phase 1/2 results and signaling pathway implications , 2015, Cancer.
[22] Steven J. M. Jones,et al. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer , 2015, Cell.
[23] T. Roberts,et al. A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis , 2015, Nature Communications.
[24] David C. Smith,et al. Integrative Clinical Genomics of Advanced Prostate Cancer , 2015, Cell.
[25] Lawrence D. True,et al. Integrative Clinical Genomics of Advanced Prostate Cancer , 2015, Cell.
[26] Michael G. Kharas,et al. PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer , 2015, Science Translational Medicine.
[27] V. Gandhi,et al. Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma , 2015, Clinical Cancer Research.
[28] J. Engelman,et al. Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer. , 2015, Cancer cell.
[29] Simon T Barry,et al. Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ. , 2015, Cancer cell.
[30] S. Barry,et al. Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel , 2014, Molecular Cancer Therapeutics.
[31] Obi L. Griffith,et al. Convergent loss of PTEN leads to clinical resistance to a PI3Kα inhibitor , 2014, Nature.
[32] Hans Clevers,et al. Organoid Cultures Derived from Patients with Advanced Prostate Cancer , 2014, Cell.
[33] E. Cuppen,et al. Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures , 2014, Cell.
[34] T. Roberts,et al. PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context , 2014, Proceedings of the National Academy of Sciences.
[35] A. Zelenetz,et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. , 2014, The New England journal of medicine.
[36] D. Erdmann,et al. Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials , 2014, Molecular Cancer Therapeutics.
[37] Christof Fellmann,et al. An optimized microRNA backbone for effective single-copy RNAi. , 2013, Cell reports.
[38] G. Hampton,et al. Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068 , 2013, Clinical Cancer Research.
[39] Tyler T. Risom,et al. Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models , 2013, Clinical Cancer Research.
[40] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumors , 2012, Nature.
[41] N. Gray,et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. , 2012, Cancer discovery.
[42] Jing Li,et al. Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background , 2012, Molecular Cancer Therapeutics.
[43] Sarat Chandarlapaty,et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. , 2011, Cancer cell.
[44] Cole Trapnell,et al. Improving RNA-Seq expression estimates by correcting for fragment bias , 2011, Genome Biology.
[45] Jeffrey A. Engelman,et al. Targeting PI3K signalling in cancer: opportunities, challenges and limitations , 2009, Nature Reviews Cancer.
[46] Pixu Liu,et al. Targeting the phosphoinositide 3-kinase pathway in cancer , 2009, Nature Reviews Drug Discovery.
[47] T. Roberts,et al. Should individual PI3 kinase isoforms be targeted in cancer? , 2009, Current opinion in cell biology.
[48] Alice T. Loo,et al. PTEN-deficient cancers depend on PIK3CB , 2008, Proceedings of the National Academy of Sciences.
[49] M. Jeschke. Faculty Opinions recommendation of Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. , 2008 .
[50] M. Loda,et al. Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis , 2008, Nature.
[51] Hailing Cheng,et al. The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation , 2006, Proceedings of the National Academy of Sciences.
[52] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[53] J. Olefsky,et al. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. , 1996, Endocrinology.
[54] Thomas R. Gingeras,et al. STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..
[55] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumours , 2013 .
[56] Jing Li,et al. Preclinical Development Preclinical Pharmacology of AZD 5363 , an Inhibitor of AKT : Pharmacodynamics , Antitumor Activity , and Correlation of Monotherapy Activity with Genetic Background , 2012 .