Cellular oxygen sensing need in CNS function: physiological and pathological implications
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[1] Brian Keith,et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. , 2003, Molecular and cellular biology.
[2] B. Brüne,et al. PI3K/Akt Is Required for Heat Shock Proteins to Protect Hypoxia-inducible Factor 1α from pVHL-independent Degradation* , 2004, Journal of Biological Chemistry.
[3] J. Hoidal,et al. Role of components of the phagocytic NADPH oxidase in oxygen sensing. , 2002, Journal of applied physiology.
[4] C. Peers,et al. NADPH oxidase does not account fully for O2-sensing in model airway chemoreceptor cells. , 2001, Biochemical and biophysical research communications.
[5] R. Busse,et al. Oxidative stress and expression of p22phox are involved in the up‐regulation of tissue factor in vascular smooth muscle cells in response to activated platelets , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[6] L. del Peso,et al. The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen* , 2003, Journal of Biological Chemistry.
[7] S. McKnight,et al. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF , 2001, Science.
[8] Charis Eng,et al. A role for mitochondrial enzymes in inherited neoplasia and beyond , 2003, Nature Reviews Cancer.
[9] M. Lazdunski,et al. Susceptibility of cloned K+ channels to reactive oxygen species. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[10] Brian Keith,et al. Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation , 2003, Molecular and Cellular Biology.
[11] D. Lübbers,et al. Regulation of local tissuePo2of the brain cortex at different arterial O2 pressures , 1975, Pflügers Archiv.
[12] T. Mcclanahan,et al. Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.
[13] R. Wenger,et al. The hypoxia-inducible factor-1α is a negative factor for tumor therapy , 2003, Oncogene.
[14] Thilo Hagen,et al. Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α , 2003, Science.
[15] D. Peet,et al. Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch , 2002, Science.
[16] Eun-Joung Moon,et al. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes , 2001, Nature Medicine.
[17] M. Gassmann,et al. Regulation of the multidrug resistance transporter P‐glycoprotein in multicellular tumor spheroids by hypoxia‐inducible factor‐1 and reactive oxygen species , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[18] T. Acker,et al. Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. , 2000, The American journal of pathology.
[19] A. Harris,et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. , 1998, Blood.
[20] Sridhar S Kannurpatti,et al. Regional dynamics of the fMRI‐BOLD signal response to hypoxia‐hypercapnia in the rat brain , 2003, Journal of magnetic resonance imaging : JMRI.
[21] A. Chakrabartty,et al. Oxidation-induced Misfolding and Aggregation of Superoxide Dismutase and Its Implications for Amyotrophic Lateral Sclerosis* , 2002, The Journal of Biological Chemistry.
[22] A. Harris,et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[23] G. Semenza,et al. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. , 1995, Biochemical and biophysical research communications.
[24] D. Zagzag,et al. Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia‐inducible factor (HIF‐1α) in glioma cell invasion , 2003, Journal of cellular physiology.
[25] J. Dichgans,et al. Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt , 2002, The Journal of Neuroscience.
[26] M. Matthay,et al. Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells , 2004, Journal of Biological Chemistry.
[27] M. Gassmann,et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor , 1996, Molecular and cellular biology.
[28] A. Harris,et al. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. , 2003, Cancer research.
[29] J. Haddad,et al. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. , 2001, FEBS letters.
[30] E. J. Song,et al. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. , 2002, Cell.
[31] D. Mottet,et al. Is HIF-1α a pro- or an anti-apoptotic protein? ☆ , 2002 .
[32] Y. Furukawa,et al. Stimulation of GATA‐2 as a mechanism of hydrogen peroxide suppression in hypoxia‐induced erythropoietin gene expression , 2001, Journal of cellular physiology.
[33] J. Rafols,et al. Insulin Induces Dephosphorylation of Eukaryotic Initiation Factor 2α and Restores Protein Synthesis in Vulnerable Hippocampal Neurons after Transient Brain Ischemia , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[34] Hirofumi Nakatomi,et al. Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors , 2002, Cell.
[35] R. Jones,et al. NADPH oxidase: a universal oxygen sensor? , 2000, Free radical biology & medicine.
[36] Michael I. Wilson,et al. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.
[37] William Wisden,et al. Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance , 2001, Nature.
[38] M. Taubman,et al. Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. , 2002, Biochemistry and cell biology = Biochimie et biologie cellulaire.
[39] W. Jelkmann,et al. Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing , 2003, Journal of Cell Science.
[40] Toxic Proteins , 2001, Science's STKE.
[41] J. Howell,et al. A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets* , 2003, Journal of Biological Chemistry.
[42] G. Semenza,et al. Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain , 1999, The European journal of neuroscience.
[43] J. Haddad,et al. A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α , 2001 .
[44] Margaret C. Neville,et al. HIF1α is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland , 2003 .
[45] S. Lahiri,et al. Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca2+]i and respiratory responses to hypoxia , 2000, Brain Research.
[46] K. Jin,et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[47] S. Saccani,et al. Regulation of the Chemokine Receptor CXCR4 by Hypoxia , 2003, The Journal of experimental medicine.
[48] J. Pouysségur,et al. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. , 2000, The Journal of biological chemistry.
[49] Ulrich Dirnagl,et al. Ischemic tolerance and endogenous neuroprotection , 2003, Trends in Neurosciences.
[50] K. Jin,et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. , 2003, The Journal of clinical investigation.
[51] L. Poellinger,et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[52] S. Weiss,et al. Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells , 2001, The Journal of Neuroscience.
[53] J. Lambeth,et al. Novel homologs of gp91phox. , 2000, Trends in biochemical sciences.
[54] P. W. Hochachka,et al. Mechanism, origin, and evolution of anoxia tolerance in animals. , 2000, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
[55] H. Lander. An essential role for free radicals and derived species in signal transduction , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[56] R. Wenger,et al. Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[57] Ulrich Müller,et al. Mutations in SDHC cause autosomal dominant paraganglioma, type 3 , 2000, Nature Genetics.
[58] L. Huang,et al. Hypoxia-inducible Factor and Its Biomedical Relevance* , 2003, Journal of Biological Chemistry.
[59] Andrew L. Kung,et al. Suppression of tumor growth through disruption of hypoxia-inducible transcription , 2000, Nature Medicine.
[60] G G Haddad,et al. A direct mechanism for sensing low oxygen levels by central neurons. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[61] J. Caro,et al. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. , 1997, The Journal of biological chemistry.
[62] G. Semenza,et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. , 2003, Cancer research.
[63] Stuart A. Lipton,et al. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades , 2001, Nature.
[64] Icksoo Lee,et al. New Control of Mitochondrial Membrane Potential and ROS Formation A Hypothesis , 2001, Biological chemistry.
[65] M. Álvarez-Tejado,et al. Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension* , 2002, The Journal of Biological Chemistry.
[66] P. Sutphin,et al. Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α* , 2002, The Journal of Biological Chemistry.
[67] David J. Anderson,et al. Culture in Reduced Levels of Oxygen Promotes Clonogenic Sympathoadrenal Differentiation by Isolated Neural Crest Stem Cells , 2000, The Journal of Neuroscience.
[68] G. Semenza,et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. , 2000, Cancer research.
[69] U. Dirnagl,et al. Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin , 2003, Stroke.
[70] A. Nairn,et al. Changes in the phosphorylation of initiation factor eIF‐2α, elongation factor eEF‐2 and p70 S6 kinase after transient focal cerebral ischaemia in mice , 2001, Journal of neurochemistry.
[71] F. Doetsch,et al. The glial identity of neural stem cells , 2003, Nature Neuroscience.
[72] M. Lazdunski,et al. The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1 , 2001, The EMBO journal.
[73] P. Carmeliet,et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis , 1998, Nature.
[74] C. Lok,et al. Identification of a Hypoxia Response Element in the Transferrin Receptor Gene* , 1999, The Journal of Biological Chemistry.
[75] F. Agani,et al. Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia. , 2000, Journal of applied physiology.
[76] F R Sharp,et al. Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils , 1998, The Journal of Neuroscience.
[77] L. Poellinger,et al. Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α , 2000, Molecular and Cellular Biology.
[78] A. Paetau,et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer , 2002, Nature Genetics.
[79] N. Chandel,et al. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[80] G. Semenza,et al. Role of hypoxia‐inducible factor‐1 in hypoxia‐induced ischemic tolerance in neonatal rat brain , 2000, Annals of neurology.
[81] D. Mottet,et al. Regulation of Hypoxia-inducible Factor-1α Protein Level during Hypoxic Conditions by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Pathway in HepG2 Cells* , 2003, Journal of Biological Chemistry.
[82] M. Dinauer,et al. NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[83] G. Semenza,et al. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. , 1995, Biochemical and biophysical research communications.
[84] J. LaManna,et al. Hypoxia-inducible factor-1alpha accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging. , 2003, Advances in experimental medicine and biology.
[85] T Kobayashi,et al. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. , 2001, Genes & development.
[86] H. Acker,et al. Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body. , 1990, The Biochemical journal.
[87] D. Mottet,et al. Is HIF-1alpha a pro- or an anti-apoptotic protein? , 2002, Biochemical pharmacology.
[88] K. Jungermann,et al. A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[89] M. Gassmann,et al. Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions. , 2000, Biochimica et biophysica acta.
[90] L. Neckers,et al. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. , 2002, The Journal of biological chemistry.
[91] C. Chiang,et al. Hypoxia Actively Represses Transcription by Inducing Negative Cofactor 2 (Dr1/DrAP1) and Blocking Preinitiation Complex Assembly* , 2003, The Journal of Biological Chemistry.
[92] A. Alcázar,et al. Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain , 2001 .
[93] G. Semenza,et al. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. , 1996, Biochemical and biophysical research communications.
[94] R. Schmidt-Kastner,et al. Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death , 2001, European Archives of Psychiatry and Clinical Neuroscience.
[95] Tae-You Kim,et al. A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene. , 2002, The Biochemical journal.
[96] G. Booker,et al. The subtle side to hypoxia inducible factor (HIFalpha) regulation. , 2003, European journal of biochemistry.
[97] Tarik Tihan,et al. The hypoxic response of tumors is dependent on their microenvironment. , 2003, Cancer cell.
[98] K. Kivirikko,et al. Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor* , 2003, Journal of Biological Chemistry.
[99] Y. Zou,et al. Hypoxia-associated Induction of Early Growth Response-1 Gene Expression* , 1999, The Journal of Biological Chemistry.
[100] B. Mazumder,et al. Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency* , 2000, The Journal of Biological Chemistry.
[101] L. Neckers,et al. Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway* , 2002, The Journal of Biological Chemistry.
[102] D. Livingston,et al. Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit* , 1996, The Journal of Biological Chemistry.
[103] N. Chandel,et al. Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia , 2000, The Journal of Biological Chemistry.
[104] Moon-Kyoung Bae,et al. Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation , 2002, Cell.
[105] J. Pouysségur,et al. HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia , 2003, The EMBO journal.
[106] M. Noble,et al. Redox State as a Central Modulator of Precursor Cell Function , 2003, Annals of the New York Academy of Sciences.
[107] H. Acker,et al. Unusual cytochrome a592 with low PO2 affinity correlates as putative oxygen sensor with rat carotid body chemoreceptor discharge , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[108] Yuichi Makino,et al. Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus* , 2002, The Journal of Biological Chemistry.
[109] A. Harris,et al. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. , 2003, Cancer research.
[110] P. Bickler,et al. Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons , 2003, Neuroscience.
[111] L. Poellinger,et al. A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor* , 2000, The Journal of Biological Chemistry.
[112] D. Lübbers,et al. Measurements of the partial pressure of oxygen in the carotid body of fetal sheep and newborn lambs. , 1980, Journal of developmental physiology.
[113] P. Comoglio,et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. , 2003, Cancer cell.
[114] D. Mottet,et al. Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. , 1999, FEBS letters.
[115] G. Goodall,et al. Hypoxia-inducible Factor-1 (cid:1) mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia , 2022 .
[116] L. Szweda,et al. Modulation of Mitochondrial Function by Hydrogen Peroxide* , 2001, The Journal of Biological Chemistry.
[117] P. Eriksson,et al. Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus , 2000, The Journal of Neuroscience.
[118] B. Devlin,et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. , 2000, Science.
[119] Y. Fujii‐Kuriyama,et al. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300 , 1999, The EMBO journal.
[120] G. Goodall,et al. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. , 2002, Molecular biology of the cell.
[121] P. Ratcliffe,et al. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. , 2001, Blood.
[122] E. Mackenzie,et al. A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[123] A. Alcázar,et al. Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. , 2001, The Biochemical journal.
[124] A. Koong,et al. Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.
[125] Christopher J Schofield,et al. Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family* , 2002, The Journal of Biological Chemistry.
[126] K. Fischbeck,et al. Toxic Proteins in Neurodegenerative Disease , 2002, Science.
[127] Nadine Kabbani,et al. Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen , 2000, The Journal of Neuroscience.
[128] M. Gassmann,et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. , 1998, Genes & development.
[129] G. Booker,et al. The subtle side to hypoxia inducible factor (HIFα) regulation , 2003 .
[130] A. Mithöfer,et al. Involvement of an NAD(P)H oxidase in the elicitor-inducible oxidative burst of soybean , 1997 .
[131] K. Nozaki,et al. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice , 1999, Brain Research.
[132] E S Husebye,et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. , 2001, American journal of human genetics.
[133] G. Semenza,et al. Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1* , 2001, The Journal of Biological Chemistry.
[134] H. Yeger,et al. Respiratory control in neonatal mice with NADPH oxidase deficiency. , 2001, Respiration physiology.
[135] M. Bernaudin,et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. , 2000, The American journal of pathology.
[136] T. Acker,et al. A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology , 2002, Journal of Molecular Medicine.
[137] W. Jelkmann,et al. Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis. , 1998, Respiration physiology.
[138] Kai-Uwe Eckardt,et al. The FASEB Journal express article 10.1096/fj.02-0445fje. Published online December 17, 2002. Widespread, hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs , 2022 .
[139] F. Jöbsis,et al. Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. , 1972, Journal of neurophysiology.
[140] N. Sonenberg,et al. Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α , 2002, Molecular and Cellular Biology.
[141] Christian Frelin,et al. Hypoxia Up-regulates Prolyl Hydroxylase Activity , 2003, Journal of Biological Chemistry.
[142] B. Bowen,et al. Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. , 2003, Biochemical and biophysical research communications.
[143] R. Wenger,et al. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. , 2003, Oncogene.
[144] W. Seeger,et al. Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)? , 2000, American journal of physiology. Lung cellular and molecular physiology.
[145] E. Mackenzie,et al. Normobaric Hypoxia Induces Tolerance to Focal Permanent Cerebral Ischemia in Association with an Increased Expression of Hypoxia-Inducible Factor-1 and its Target Genes, Erythropoietin and VEGF, in the Adult Mouse Brain , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[146] Jessica Lo,et al. HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .
[147] M. Halterman,et al. Hypoxia-Inducible Factor-1α Mediates Hypoxia-Induced Delayed Neuronal Death That Involves p53 , 1999, The Journal of Neuroscience.
[148] H. Ryan,et al. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. , 1998, The EMBO journal.
[149] Till Acker,et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration , 2001, Nature Genetics.
[150] P. Carmeliet,et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death , 2003, Nature Genetics.
[151] O. Lindvall,et al. Neuronal replacement from endogenous precursors in the adult brain after stroke , 2002, Nature Medicine.
[152] David A. Greenberg,et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[153] K. Jin,et al. Stem cell factor stimulates neurogenesis in vitro and in vivo. , 2002, The Journal of clinical investigation.
[154] G. Semenza. Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.
[155] G. Semenza,et al. Purification and Characterization of Hypoxia-inducible Factor 1 (*) , 1995, The Journal of Biological Chemistry.
[156] M. Gassmann,et al. Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1* , 1997, The Journal of Biological Chemistry.
[157] Bryan Welm,et al. HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. , 2003, Development.
[158] G. Semenza,et al. Expression of hypoxia‐inducible factor 1α in brain tumors , 2000 .
[159] Elias S. J. Arnér,et al. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. , 2001, Free radical biology & medicine.
[160] G. Mies,et al. Dynamics of Regional Brain Metabolism and Gene Expression After Middle Cerebral Artery Occlusion in Mice , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[161] Till Acker,et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice , 2002, Nature Medicine.
[162] T. Acker,et al. Role of hypoxia in tumor angiogenesis—molecular and cellular angiogenic crosstalk , 2003, Cell and Tissue Research.
[163] H. Cai,et al. Genetically engineered mouse models of neurodegenerative diseases , 2002, Nature Neuroscience.
[164] P. Maher,et al. The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide , 2003, Neuron.
[165] J. Klein,et al. Hypoxia induces an autocrine‐paracrine survival pathway via platelet‐derived growth factor (PDGF)‐B/PDGF‐β receptor/phosphatidylinositol 3‐kinase/Akt signaling in RN46A neuronal cells , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[166] M. Gassmann,et al. HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[167] S Cluskey,et al. Mechanisms of neurodegeneration in amyotrophic lateral sclerosis , 2001, Molecular pathology : MP.
[168] A. Harris,et al. Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. , 2000, Cancer research.
[169] R. Altman,et al. Investigating hypoxic tumor physiology through gene expression patterns , 2003, Oncogene.
[170] W. Jelkmann,et al. Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species. , 1997, Kidney international.
[171] U. Dirnagl,et al. Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemia in Vivo and in Vitro , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[172] S. Lahiri,et al. The primary oxygen sensor of the cat carotid body is cytochrome a 3 of the mitochondrial respiratory chain , 1994, FEBS letters.
[173] J. Fandrey,et al. Reactive oxygen species as regulators of oxygen dependent gene expression. , 2000, Advances in experimental medicine and biology.
[174] K. Nguyen,et al. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. , 2000, Circulation research.
[175] Peter Carmeliet,et al. VEGF: a critical player in neurodegeneration. , 2004, The Journal of clinical investigation.
[176] A. Giaccia,et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. , 2003, Molecular and cellular biology.
[177] R. Freeman,et al. Single-Neuron Activity and Tissue Oxygenation in the Cerebral Cortex , 2003, Science.
[178] Erwin G. Van Meir,et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. , 2002, Cancer research.
[179] Varda Rotter,et al. Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. , 2003, Cancer research.
[180] G. Powis,et al. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. , 2002, Cancer research.
[181] G. Semenza,et al. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. , 2000, Cancer.
[182] A. Koong,et al. Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). , 1994, Cancer research.
[183] M. Martín,et al. Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells. , 2000, The Biochemical journal.
[184] D. Mottet,et al. Hypoxia‐induced activation of HIF‐1: role of HIF‐1α‐Hsp90 interaction , 1999 .
[185] Mark A. Smith,et al. Iron: A Pathological Mediator of Alzheimer Disease? , 2002, Developmental Neuroscience.
[186] K. Jellinger,et al. Preferential Loss of Myelin‐Associated Glycoprotein Reflects Hypoxia‐Like White Matter Damage in Stroke and Inflammatory Brain Diseases , 2003, Journal of neuropathology and experimental neurology.
[187] T. Porwol,et al. Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species. , 2001, Respiration physiology.
[188] C. Peers,et al. O(2) sensing by airway chemoreceptor-derived cells. Protein kinase c activation reveals functional evidence for involvement of NADPH oxidase. , 2000, The Journal of biological chemistry.
[189] G. Booker,et al. Substrate Requirements of the Oxygen-sensing Asparaginyl Hydroxylase Factor-inhibiting Hypoxia-inducible Factor* , 2004, Journal of Biological Chemistry.
[190] Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. , 2002, Seminars in cell & developmental biology.
[191] H. Moch,et al. Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL , 2003, Nature.
[192] A. Giaccia,et al. Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α , 2003, Molecular and Cellular Biology.
[193] R. Kopito,et al. Impairment of the ubiquitin-proteasome system by protein aggregation. , 2001, Science.
[194] M. King,et al. Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway* , 2001, The Journal of Biological Chemistry.
[195] M. Westphal,et al. Scatter factor/hepatocyte growth factor (SF/HGF) content and function in human gliomas , 1999, International Journal of Developmental Neuroscience.
[196] S. Archer,et al. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[197] Matthias Schramm,et al. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. , 2002, Biochemical and biophysical research communications.
[198] Till Acker,et al. Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)* , 2003, The Journal of Biological Chemistry.
[199] P. Arthur,et al. Lack of oxygen sensing by mitochondria in platelets. , 1999, European journal of biochemistry.
[200] C. Thrash-Bingham,et al. aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia. , 1999, Journal of the National Cancer Institute.