Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis

[1]  V. Papadopoulos,et al.  Role of mitochondria in steroidogenesis. , 2012, Best practice & research. Clinical endocrinology & metabolism.

[2]  V. Vié,et al.  Mouse TSPO in a lipid environment interacting with a functionalized monolayer. , 2012, Biochimica et biophysica acta.

[3]  V. Gottifredi,et al.  Mitochondrial Fusion Is Essential for Steroid Biosynthesis , 2012, PloS one.

[4]  T. Veenstra,et al.  Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones. , 2012, Molecular endocrinology.

[5]  L. Scorrano,et al.  Optic Atrophy 1-Dependent Mitochondrial Remodeling Controls Steroidogenesis in Trophoblasts , 2012, Current Biology.

[6]  Robert V Farese,et al.  Lipid droplets and cellular lipid metabolism. , 2012, Annual review of biochemistry.

[7]  F. Kraemer,et al.  Ablation of vimentin results in defective steroidogenesis. , 2012, Endocrinology.

[8]  T. Veenstra,et al.  Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells* , 2012, The Journal of Biological Chemistry.

[9]  B. J. Clark,et al.  The mammalian START domain protein family in lipid transport in health and disease. , 2012, The Journal of endocrinology.

[10]  D. Rousseau,et al.  ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression , 2012, Journal of Bioenergetics and Biomembranes.

[11]  I. Tabas,et al.  Role of endoplasmic reticulum stress in metabolic disease and other disorders. , 2012, Annual review of medicine.

[12]  Teruo Hayashi,et al.  The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria. , 2012, Biochemical and biophysical research communications.

[13]  Hong Wang,et al.  Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria[S] , 2011, Journal of Lipid Research.

[14]  W. Miller,et al.  Early steps in steroidogenesis: intracellular cholesterol trafficking , 2011, Journal of Lipid Research.

[15]  M. Brimble,et al.  The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. , 2011, Biochimica et biophysica acta.

[16]  Matthew West,et al.  ER Tubules Mark Sites of Mitochondrial Division , 2011, Science.

[17]  D. Stojanovski,et al.  The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. , 2011, Cellular signalling.

[18]  R. Schneiter,et al.  Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae , 2011, Journal of Cell Science.

[19]  P. J. McFie,et al.  Murine Diacylglycerol Acyltransferase-2 (DGAT2) Can Catalyze Triacylglycerol Synthesis and Promote Lipid Droplet Formation Independent of Its Localization to the Endoplasmic Reticulum* , 2011, The Journal of Biological Chemistry.

[20]  C. Hoppel,et al.  Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex* , 2011, The Journal of Biological Chemistry.

[21]  F. Ricchelli,et al.  Shedding light on the mitochondrial permeability transition. , 2011, Biochimica et biophysica acta.

[22]  M. Michalak,et al.  Organellar calcium buffers. , 2011, Cold Spring Harbor perspectives in biology.

[23]  V. Papadopoulos,et al.  ATP Synthesis, Mitochondrial Function, and Steroid Biosynthesis in Rodent Primary and Tumor Leydig Cells1 , 2011, Biology of reproduction.

[24]  Gerhard Rammes,et al.  Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders , 2010, Nature Reviews Drug Discovery.

[25]  F. Ricchelli,et al.  Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral Benzodiazepine Receptor)* , 2010, The Journal of Biological Chemistry.

[26]  T. Nilsson,et al.  Biogenesis of lipid droplets – how cells get fatter , 2010, Molecular membrane biology.

[27]  M. Rojo,et al.  [Mitochondrial morphology and dynamics: actors, mechanisms and functions]. , 2010, Medecine sciences : M/S.

[28]  Luca Scorrano,et al.  An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship , 2010, The EMBO journal.

[29]  T. Simmen,et al.  Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM). , 2010, Biochimica et biophysica acta.

[30]  M. Palacín,et al.  Mitochondrial fusion proteins: dual regulators of morphology and metabolism. , 2010, Seminars in cell & developmental biology.

[31]  György Hajnóczky,et al.  Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. , 2010, Molecular cell.

[32]  F. Gallyas,et al.  TIP47 protects mitochondrial membrane integrity and inhibits oxidative‐stress‐induced cell death , 2010, FEBS letters.

[33]  C. Sachse,et al.  Three-Dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals , 2010, Structure.

[34]  J. Füllekrug,et al.  Lipid droplets lighting up: Insights from live microscopy , 2010, FEBS letters.

[35]  H. Jäckle,et al.  Lipid droplets: A dynamic organelle moves into focus , 2010, FEBS letters.

[36]  W. Shen,et al.  Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones , 2010, Nutrition & metabolism.

[37]  V. De Pinto,et al.  VDAC, a multi-functional mitochondrial protein regulating cell life and death. , 2010, Molecular aspects of medicine.

[38]  S. Sugano,et al.  ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells , 2010, Journal of Cell Science.

[39]  A. Kimmel,et al.  Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins , 2010, Journal of Lipid Research.

[40]  J. Baudier,et al.  The AAA+ ATPase ATAD3A Controls Mitochondrial Dynamics at the Interface of the Inner and Outer Membranes , 2010, Molecular and Cellular Biology.

[41]  E. Mayatepek,et al.  C. elegans ATAD-3 Is Essential for Mitochondrial Activity and Development , 2009, PloS one.

[42]  V. Papadopoulos,et al.  Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. , 2009, Biochimica et biophysica acta.

[43]  D. Stocco,et al.  Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives. , 2009, Molecular human reproduction.

[44]  A. Halestrap.  What is the mitochondrial permeability transition pore? , 2009, Journal of molecular and cellular cardiology.

[45]  P. Lavigne,et al.  Toward the NMR structure of StAR , 2009, Molecular and Cellular Endocrinology.

[46]  Robert V Farese,et al.  The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria* , 2009, Journal of Biological Chemistry.

[47]  Gong Peng,et al.  A role for lipid droplets in inter‐membrane lipid traffic , 2009, Proteomics.

[48]  L. Scorrano,et al.  Mitofusin 2 tethers endoplasmic reticulum to mitochondria , 2008, Nature.

[49]  M. Sewer,et al.  Regulation of Steroid Hormone Biosynthesis by the Cytoskeleton , 2008, Lipids.

[50]  A. Pastore,et al.  Dynamics, stability and iron‐binding activity of frataxin clinical mutants , 2008, The FEBS journal.

[51]  V. Papadopoulos,et al.  Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding. , 2008, Biochimica et biophysica acta.

[52]  W. Miller,et al.  Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein , 2008, Journal of Biological Chemistry.

[53]  M. Duchen,et al.  Mitochondria: the hub of cellular Ca2+ signaling. , 2008, Physiology.

[54]  Z. Granot,et al.  Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors. , 2007, Molecular endocrinology.

[55]  J. McCaffery,et al.  Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum , 2007, Cell.

[56]  W. Miller.  Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. , 2007, Biochimica et biophysica acta.

[57]  W. Craigen,et al.  Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death , 2007, Nature Cell Biology.

[58]  T. Veenstra,et al.  Targeting and insertion of the cholesterol‐binding Translocator Protein into the outer mitochondrial membrane , 2007, Biochemistry.

[59]  A. F. Castillo,et al.  Enzymes involved in arachidonic acid release in adrenal and Leydig cells , 2007, Molecular and Cellular Endocrinology.

[60]  Z. Granot,et al.  Turnover of StAR protein: Roles for the proteasome and mitochondrial proteases , 2007, Molecular and Cellular Endocrinology.

[61]  A. Reyes,et al.  The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization , 2007, The Journal of cell biology.

[62]  V. Papadopoulos,et al.  Protein-Protein Interactions Mediate Mitochondrial Cholesterol Transport and Steroid Biosynthesis* , 2006, Journal of Biological Chemistry.

[63]  S. Duvezin-Caubet,et al.  Proteolytic Processing of OPA1 Links Mitochondrial Dysfunction to Alterations in Mitochondrial Morphology* , 2006, Journal of Biological Chemistry.

[64]  D. B. Hales,et al.  Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. , 2006, Endocrinology.

[65]  Sara Cipolat,et al.  OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion , 2006, Cell.

[66]  D. Zorov,et al.  Mitochondrial contact sites: their role in energy metabolism and apoptosis. , 2006, Biochimica et biophysica acta.

[67]  C. Blackstone,et al.  Release of OPA1 during Apoptosis Participates in the Rapid and Complete Release of Cytochrome c and Subsequent Mitochondrial Fragmentation* , 2005, Journal of Biological Chemistry.

[68]  C. Tomasetto,et al.  Give lipids a START: the StAR-related lipid transfer (START) domain in mammals , 2005, Journal of Cell Science.

[69]  H. Taniguchi,et al.  Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane , 2005, Journal of Cell Science.

[70]  C. Paz,et al.  Silencing the expression of mitochondrial acyl‐CoA thioesterase I and acyl‐CoA synthetase 4 inhibits hormone‐induced steroidogenesis , 2005, The FEBS journal.

[71]  L. Wan,et al.  PACS‐2 controls endoplasmic reticulum–mitochondria communication and Bid‐mediated apoptosis , 2005, The EMBO journal.

[72]  V. Papadopoulos,et al.  Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria , 2005 .

[73]  R. Youle,et al.  Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. , 2004, Molecular biology of the cell.

[74]  L. Hunyady,et al.  Control of aldosterone secretion: a model for convergence in cellular signaling pathways. , 2004, Physiological reviews.

[75]  Jean-Claude Martinou,et al.  Proteomic Analysis of the Mouse Liver Mitochondrial Inner Membrane* , 2003, Journal of Biological Chemistry.

[76]  V. Papadopoulos,et al.  Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. , 2003, Steroids.

[77]  J. Strauss,et al.  START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells , 2003, Molecular and Cellular Endocrinology.

[78]  V. Papadopoulos,et al.  In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding. , 2003, Biochemistry.

[79]  M. Thomson.  Does cholesterol use the mitochondrial contact site as a conduit to the steroidogenic pathway? , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[80]  W. Miller,et al.  Transfer of Cholesterol between Phospholipid Vesicles Mediated by the Steroidogenic Acute Regulatory Protein (StAR)* , 2002, The Journal of Biological Chemistry.

[81]  C. Jefcoate.  High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex. , 2002, The Journal of clinical investigation.

[82]  T. M. Lewin,et al.  Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. , 2002, Archives of biochemistry and biophysics.

[83]  V. Lingappa,et al.  Rapid regulation of steroidogenesis by mitochondrial protein import , 2002, Nature.

[84]  A. Lombès,et al.  Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. , 2002, Journal of cell science.

[85]  Dong Zhao,et al.  Mitochondrial Processing of Newly Synthesized Steroidogenic Acute Regulatory Protein (StAR), but Not Total StAR, Mediates Cholesterol Transfer to Cytochrome P450 Side Chain Cleavage Enzyme in Adrenal Cells* , 2001, The Journal of Biological Chemistry.

[86]  V. Papadopoulos,et al.  Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. , 2001, Molecular endocrinology.

[87]  B. Lorenz,et al.  Mutation spectrum and splicing variants in the OPA1 gene , 2001, Human Genetics.

[88]  J. Strauss,et al.  Steroidogenic Acute Regulatory Protein Binds Cholesterol and Modulates Mitochondrial Membrane Sterol Domain Dynamics* , 2001, The Journal of Biological Chemistry.

[89]  V. Papadopoulos,et al.  Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[90]  J. Grosgeorge,et al.  Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy , 2000, Nature Genetics.

[91]  S. Bhattacharya,et al.  OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 , 2000, Nature Genetics.

[92]  B. Cooke.  Signal transduction involving cyclic AMP-dependent and cyclic AMP-independent mechanisms in the control of steroidogenesis , 1999, Molecular and Cellular Endocrinology.

[93]  V. Papadopoulos,et al.  In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis , 1999, The Journal of Steroid Biochemistry and Molecular Biology.

[94]  M. Yaffe,et al.  The machinery of mitochondrial inheritance and behavior. , 1999, Science.

[95]  A. M. van der Bliek,et al.  A Human Dynamin-related Protein Controls the Distribution of Mitochondria , 1998, The Journal of cell biology.

[96]  Lawrence M. Lifshitz,et al.  Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. , 1998, Science.

[97]  K. G. Hales,et al.  Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase , 1997, Cell.

[98]  V. Papadopoulos,et al.  Acute action of choriogonadotropin on Leydig tumor cells: changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor. , 1996, Endocrinology.

[99]  D. Stocco,et al.  Regulation of the acute production of steroids in steroidogenic cells. , 1996, Endocrine reviews.

[100]  D. Williams,et al.  Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. , 1996, Biochemical pharmacology.

[101]  A. Kimmel,et al.  Perilipins Are Associated with Cholesteryl Ester Droplets in Steroidogenic Adrenal Cortical and Leydig Cells (*) , 1995, The Journal of Biological Chemistry.

[102]  V. Papadopoulosa,et al.  Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor , 1994, Molecular and Cellular Endocrinology.

[103]  V. Papadopoulos,et al.  In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. , 1994, Molecular pharmacology.

[104]  T. Pozzan,et al.  Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. , 1993, Science.

[105]  V. Papadopoulos.  Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. , 1993, Endocrine reviews.

[106]  P. Hall,et al.  The role of the cytoskeleton in the regulation of steroidogenesis , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[107]  P. Hall,et al.  Attachment of mitochondria to intermediate filaments in adrenal cells: relevance to the regulation of steroid synthesis. , 1992, Experimental cell research.

[108]  S. Snyder,et al.  Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[109]  D. Williams,et al.  The effects of the peripheral-type benzodiazepine acceptor ligands, Ro 5-4864 and PK 11195, on mitochondrial respiration. , 1992, Methods and findings in experimental and clinical pharmacology.

[110]  P. Hall,et al.  Attachment of steroidogenic lipid droplets to intermediate filaments in adrenal cells. , 1992, Journal of cell science.

[111]  Frank McCormick,et al.  The GTPase superfamily: conserved structure and molecular mechanism , 1991, Nature.

[112]  Frank McCormick,et al.  The GTPase superfamily: a conserved switch for diverse cell functions , 1990, Nature.

[113]  L. Perkins,et al.  Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. , 1987, Endocrinology.

[114]  P. Hall,et al.  Steroidogenesis in adrenal tumor cells: influence of cell shape. , 1987, Endocrinology.

[115]  T. Kimura.  Transduction of ACTH signal from plasma membrane to mitochondria in adrenocortical steroidogenesis. Effects of peptide, phospholipid, and calcium. , 1986, Journal of steroid biochemistry.

[116]  L. Pon,et al.  Acute ACTH regulation of adrenal corticosteroid biosynthesis. Rapid accumulation of a phosphoprotein. , 1986, The Journal of biological chemistry.

[117]  L. Pon,et al.  Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones. Rapid induction of a similar protein in both tissues. , 1986, The Journal of biological chemistry.

[118]  V. Stevens,et al.  Regulation of mitochondrial compartment volumes in rat adrenal cortex by ether stress. , 1985, Archives of biochemistry and biophysics.

[119]  R. Anholt,et al.  Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. , 1985, The Journal of pharmacology and experimental therapeutics.

[120]  D. Fawcett,et al.  The fine structure of testicular interstitial cells in mice. , 1966, The American journal of anatomy.

[121]  P. Pinton,et al.  Mitochondria-associated membranes (MAMs) as hotspot Ca(2+) signaling units. , 2012, Advances in experimental medicine and biology.

[122]  B. Mignotte,et al.  The mitochondrial pathways of apoptosis. , 2012, Advances in experimental medicine and biology.

[123]  Teruo Hayashi,et al.  Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases. , 2010, Sub-cellular biochemistry.

[124]  V. Shoshan-Barmatz,et al.  The voltage-dependent anion channel , 2007, Cell Biochemistry and Biophysics.

[125]  Seungho Wang,et al.  Immunocytochemical studies on lipid droplet‐surface proteins in adrenal cells , 2002, Journal of cellular biochemistry.

[126]  C. Mannella,et al.  Electron microscopic tomography of rat‐liver mitochondria and their interactions with the endoplasmic reticulum , 1998, BioFactors.

[127]  J. Hirsch,et al.  Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control. , 1989, Molecular pharmacology.

[128]  M. Waterman,et al.  Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. , 1988, Annual review of physiology.

[129]  P. Srere,et al.  Complexes of sequential metabolic enzymes. , 1987, Annual review of biochemistry.

[130]  P. Hall,et al.  Role of cytochromes P-450 in the biosynthesis of steroid hormones. , 1985, Vitamins and hormones.

[131]  G. M. Walton,et al.  On the mechanism of action of ACTH. , 1971, Recent progress in hormone research.

[132]  J. Rhodin,et al.  The ultrastructure of the adrenal cortex of the rat under normal and experimental conditions. , 1971, Journal of ultrastructure research.

[133]  V. Papadopoulos,et al.  Printed in U.S.A. Copyright © 1998 by The Endocrine Society Peripheral-Type Benzodiazepine Receptor Function in Cholesterol Transport. Identification of a Putative Cholesterol Recognition/Interaction Amino Acid Sequence and Consensus Pattern* , 2022 .