Study of Carbamoyl Fluoride: Synthesis, Properties and Applications.

Carbamoyl fluoride is a fluorinated group which, to this date, remains underexplored, probably due to the lack of data concerning their properties. In this paper, a study of carbamoyl fluoride is proposed. Stability studies, in particular under physiological conditions, and lipophilicity measurement have been performed. A new easy, safe, inexpensive and metal-free synthesis method has also been described. Finally, a potential use in radiochemistry through a 18F/19F isotopic exchange has been demonstrated.