Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective.

[1]  A. Vidal-Puig,et al.  Origins of metabolic complications in obesity: ectopic fat accumulation. The importance of the qualitative aspect of lipotoxicity , 2011, Current opinion in clinical nutrition and metabolic care.

[2]  Antonio Vidal-Puig,et al.  An allostatic control of membrane lipid composition by SREBP1 , 2010, FEBS letters.

[3]  A. Vidal-Puig,et al.  Special issue on lipotoxicity. , 2010, Biochimica et biophysica acta.

[4]  T. Sørensen,et al.  Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? , 2010, Biochimica et biophysica acta.

[5]  Anoop Misra.  Prevention of type 2 diabetes: the long and winding road , 2009, The Lancet.

[6]  David M Nathan,et al.  10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. , 2009, Lancet.

[7]  Song Zhang,et al.  Noninvasive quantification of pancreatic fat in humans. , 2009, The Journal of clinical endocrinology and metabolism.

[8]  G. Schmitz,et al.  Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals. , 2009, The Journal of clinical endocrinology and metabolism.

[9]  A. Garg,et al.  Inherited lipodystrophies and hypertriglyceridemia , 2009, Current opinion in lipidology.

[10]  P. Scherer,et al.  Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. , 2009, Trends in pharmacological sciences.

[11]  M. Lazar,et al.  New developments in adipogenesis , 2009, Trends in Endocrinology & Metabolism.

[12]  D. Greaves,et al.  Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. , 2009, The Journal of clinical investigation.

[13]  W. Cawthorn,et al.  Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/β-Catenin Signaling Network , 2009, Diabetes.

[14]  S. O’Rahilly,et al.  Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. , 2009, The Journal of clinical investigation.

[15]  P. Govoni,et al.  Metabolic Consequences and Vulnerability to Diet-Induced Obesity in Male Mice under Chronic Social Stress , 2009, PloS one.

[16]  Philipp E. Scherer,et al.  Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI , 2008, Molecular and Cellular Biology.

[17]  J. Auwerx,et al.  Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. , 2008, Cell metabolism.

[18]  R. Hammer,et al.  White Fat Progenitor Cells Reside in the Adipose Vasculature , 2008, Science.

[19]  J. Friedman,et al.  Identification of White Adipocyte Progenitor Cells In Vivo , 2008, Cell.

[20]  A. Vidal-Puig,et al.  Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. , 2008, Biochemical Society transactions.

[21]  E. Bernal-Mizrachi,et al.  β-cell failure as a complication of diabetes , 2008, Reviews in Endocrine and Metabolic Disorders.

[22]  J. Olefsky,et al.  Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.

[23]  A. Vidal-Puig,et al.  It's Not How Fat You Are, It's What You Do with It That Counts , 2008, PLoS biology.

[24]  Bohan Wang,et al.  Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? , 2008, British Journal of Nutrition.

[25]  Tom Britton,et al.  Dynamics of fat cell turnover in humans , 2008, Nature.

[26]  A. Chawla,et al.  Cidea is associated with lipid droplets and insulin sensitivity in humans , 2008, Proceedings of the National Academy of Sciences.

[27]  M. Köhnke.  Approach to the genetics of alcoholism: a review based on pathophysiology. , 2008, Biochemical pharmacology.

[28]  G. Bray,et al.  Obesity , 2008, Annals of Internal Medicine.

[29]  Amy V. Lynch,et al.  Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.

[30]  A. Vidal-Puig,et al.  Adipose tissue expandability and the metabolic syndrome , 2007, Genes & Nutrition.

[31]  G. Shulman,et al.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.

[32]  Yihai Cao.  Angiogenesis modulates adipogenesis and obesity. , 2007, The Journal of clinical investigation.

[33]  Benjamin D. Levine,et al.  Cardiac Steatosis in Diabetes Mellitus: A 1H-Magnetic Resonance Spectroscopy Study , 2007, Circulation.

[34]  B. Pedersen,et al.  Role of myokines in exercise and metabolism. , 2007, Journal of applied physiology.

[35]  Robert V Farese,et al.  Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. , 2007, Cell metabolism.

[36]  G. Shulman,et al.  Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. , 2007, The Journal of clinical investigation.

[37]  Frank Brombacher,et al.  Macrophage-specific PPARγ controls alternative activation and improves insulin resistance , 2007, Nature.

[38]  S. McCall,et al.  Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis , 2007, Hepatology.

[39]  C. Glass,et al.  Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. , 2007, The Journal of clinical investigation.

[40]  A. Vidal-Puig,et al.  Adipose tissue expandability in the maintenance of metabolic homeostasis. , 2007, Nutrition reviews.

[41]  Yiying Zhang,et al.  Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. , 2007, The Journal of clinical investigation.

[42]  Laura Herrero,et al.  Obesity, inflammation, and insulin resistance. , 2007, Gastroenterology.

[43]  Shuzhong Zhang,et al.  Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. , 2007, The Journal of clinical investigation.

[44]  F. Heyd,et al.  Tumour necrosis factor-α inhibits adipogenesis via a β-catenin/TCF4(TCF7L2)-dependent pathway , 2007, Cell Death and Differentiation.

[45]  Laxman Yetukuri,et al.  PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism , 2007, PLoS genetics.

[46]  G. Bray,et al.  Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle , 2007, Diabetes.

[47]  C. Herder,et al.  Relationship between adipocyte size and adipokine expression and secretion. , 2007, The Journal of clinical endocrinology and metabolism.

[48]  F. Heyd,et al.  Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. , 2007, Cell death and differentiation.

[49]  P. Puigserver,et al.  Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.

[50]  B. Zinman,et al.  Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. , 2006, The New England journal of medicine.

[51]  J. Flier,et al.  TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.

[52]  S. O’Rahilly,et al.  Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice , 2006, Diabetes.

[53]  G. Heigenhauser,et al.  Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. , 2006, American journal of physiology. Endocrinology and metabolism.

[54]  Stephen J. Weiss,et al.  A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue , 2006, Cell.

[55]  S. O’Rahilly,et al.  Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. , 2006, Diabetes.

[56]  S. Summers,et al.  Ceramides in insulin resistance and lipotoxicity. , 2006, Progress in lipid research.

[57]  P. Iyengar,et al.  Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy , 2005, Nature Medicine.

[58]  M. Mcdaniel,et al.  Pancreatic β-Cell Lipoprotein Lipase Independently Regulates Islet Glucose Metabolism and Normal Insulin Secretion* , 2005, Journal of Biological Chemistry.

[59]  B. Goodpaster,et al.  Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. , 2005, Diabetes.

[60]  P. Sterling.  Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics. , 2004 .

[61]  Yihai Cao,et al.  Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice , 2004, Circulation research.

[62]  M. Gasparo,et al.  Circadian variations of blood sugar and plasma insulin levels in man , 1969, Diabetologia.

[63]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[64]  B. Brewer,et al.  Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. , 2003, The Journal of clinical investigation.

[65]  R. Eckel,et al.  Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. , 2003, Diabetes care.

[66]  J. Wingfield,et al.  The concept of allostasis in biology and biomedicine , 2003, Hormones and Behavior.

[67]  V. Poitout,et al.  Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. , 2002, Endocrinology.

[68]  B. Lowell,et al.  Adipose tissue mass can be regulated through the vasculature , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[69]  K. Frayn,et al.  Adipose tissue as a buffer for daily lipid flux , 2002, Diabetologia.

[70]  S. Fowler,et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. , 2002 .

[71]  S. Mandrup,et al.  Adipogenesis: forces that tip the scales , 2002, Trends in Endocrinology & Metabolism.

[72]  E. A. Sims,et al.  Are there persons who are obese, but metabolically healthy? , 2001, Metabolism: clinical and experimental.

[73]  Simon C Watkins,et al.  Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. , 2001, The Journal of clinical endocrinology and metabolism.

[74]  A. Häkkinen,et al.  Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. , 2001, Diabetes.

[75]  M. Jensen,et al.  Systemic and regional free fatty acid metabolism in type 2 diabetes. , 2001, American journal of physiology. Endocrinology and metabolism.

[76]  J. Horowitz,et al.  Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. , 2000, American journal of physiology. Endocrinology and metabolism.

[77]  S. O’Rahilly,et al.  Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension , 1999, Nature.

[78]  K. Chien,et al.  PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development , 1999 .

[79]  P. Scifo,et al.  Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. , 1999, Diabetes.

[80]  R. Evans,et al.  PPAR gamma is required for placental, cardiac, and adipose tissue development. , 1999, Molecular cell.

[81]  L. DiPietro,et al.  Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study , 1999, Diabetologia.

[82]  G. Reaven.  Banting lecture 1988 , 1997 .

[83]  G. Reaven.  Role of insulin resistance in human disease (syndrome X): an expanded definition. , 1993, Annual review of medicine.

[84]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.

[85]  G. Reaven.  Role of Insulin Resistance in Human Disease , 1988, Diabetes.

[86]  J. Eyer.  Hypertension as a Disease of Modern Society , 1975, International journal of health services : planning, administration, evaluation.