Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

[1]  N. Copeland,et al.  Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. , 1994, Genes & development.

[2]  P. O'Connell,et al.  Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. , 1994, The New England journal of medicine.

[3]  S. Pulst,et al.  Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. , 1994, Developmental biology.

[4]  D. Easton,et al.  An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes. , 1993, American journal of human genetics.

[5]  R. Chetty,et al.  Bilateral pheochromocytoma-ganglioneuroma of the adrenal in type 1 neurofibromatosis. , 1993, The American journal of surgical pathology.

[6]  F. Collins,et al.  An alternatively-spliced mRNA in the carboxy terminus of the neurofibromatosis type 1 (NF1) gene is expressed in muscle. , 1993, Human molecular genetics.

[7]  M. Tassabehji,et al.  Tandem duplication within a neurofibromatosis type 1 (NF1) gene exon in a family with features of Watson syndrome and Noonan syndrome. , 1993, American journal of human genetics.

[8]  A. Look,et al.  Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Gusella,et al.  Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments. , 1993, Human molecular genetics.

[10]  F. Collins,et al.  Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines , 1993, Nature Genetics.

[11]  B. Seizinger NF1: a prevalent cause of tumorigenesis in human cancers? , 1993, Nature Genetics.

[12]  F. Collins,et al.  Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis , 1993, Nature Genetics.

[13]  J. Gusella,et al.  Neurofibromatosis type 1 gene mutations in neuroblastoma , 1993, Nature Genetics.

[14]  V. Riccardi,et al.  Neurofibromatosis: Phenotype, Natural History and Pathogenesis , 1992 .

[15]  M. Daston,et al.  Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development , 1992, Developmental dynamics : an official publication of the American Association of Anatomists.

[16]  A. Berns,et al.  Requirement for a functional Rb-1 gene in murine development , 1992, Nature.

[17]  R. Weinberg,et al.  Effects of an Rb mutation in the mouse , 1992, Nature.

[18]  A. Bradley,et al.  Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis , 1992, Nature.

[19]  Barry F. Smith,et al.  Loss of NF1 alleles in phaeochromocytomas from patients with type 1 neurofibromatosis , 1992, Genes, chromosomes & cancer.

[20]  F. Collins,et al.  Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients , 1992, Nature.

[21]  D. Lowy,et al.  Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis , 1992, Cell.

[22]  R. Cawthon,et al.  Somatic mutations in the neurofibromatosis 1 gene in human tumors , 1992, Cell.

[23]  M. Daston,et al.  The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes , 1992, Neuron.

[24]  J. Green,et al.  Adrenal medullary tumors and iris proliferation in a transgenic mouse model of neurofibromatosis. , 1992, The American journal of pathology.

[25]  P. Gros,et al.  splotch (Sp2H ), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3 , 1991, Cell.

[26]  D. Lowy,et al.  Identification and characterization of the neurofibromatosis type 1 protein product. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[27]  L. Rothblum,et al.  Rapid, small-scale RNA isolation from tissue culture cells. , 1991, BioTechniques.

[28]  M. Rudnicki,et al.  Simplified mammalian DNA isolation procedure. , 1991, Nucleic acids research.

[29]  M. Wigler,et al.  The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins , 1990, Cell.

[30]  F. Tamanoi,et al.  The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae , 1990, Cell.

[31]  P. O’Connell,et al.  The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21 , 1990, Cell.

[32]  Margaret Robertson,et al.  The neurofibromatosis type 1 gene encodes a protein related to GAP , 1990, Cell.

[33]  M. Kirby,et al.  Role of Neural Crest in Congenital Heart Disease , 1990, Circulation.

[34]  B. Brownstein,et al.  Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. , 1990, Science.

[35]  P. O'Connell,et al.  Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus , 1990, Cell.

[36]  P. O'Connell,et al.  A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations , 1990, Cell.

[37]  Mario R. Capecchi,et al.  Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes , 1988, Nature.

[38]  M. Capecchi,et al.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells , 1987, Cell.

[39]  R. K. Reynolds,et al.  A transgenic mouse model for human neurofibromatosis. , 1987, Science.

[40]  H. Varmus,et al.  Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos , 1987, Cell.

[41]  M. Monk,et al.  HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells , 1987, Nature.

[42]  A. Bradley,et al.  A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice , 1987, Nature.

[43]  E. Robertson Teratocarcinomas and embryonic stem cells : a practical approach , 1987 .

[44]  T. Doetschman,et al.  Transgenesis by means of blastocyst-derived embryonic stem cell lines. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[45]  M. Kirby,et al.  Neural crest cells contribute to normal aorticopulmonary septation. , 1983, Science.

[46]  V. M. Riccardi,et al.  Von Recklinghausen neurofibromatosis. , 1981, The New England journal of medicine.

[47]  J. Mulvihill,et al.  Malignancy in neurofibromatosis. , 1985, Advances in neurology.

[48]  R. Bolande The neurocristopathies: A unifying concept of disease arising in neural crest maldevelopment , 1974 .

[49]  A. Knudson Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.