Primary irritation index and safety zone of cosmetics: retrospective analysis of skin patch tests in 7440 Korean women during 12 years

Cosmetics are products used over long periods by the public, and their safety is very important. Several types of human tests are used widely for the evaluation of cosmetics including single patch tests, in‐use tests, human repeated insult patch test (HRIPT). However, there is no clear and well‐defined published objective and standardized criteria for primary skin irritation in regard to the large variety of cosmetic products.

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