Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia

1. Vasodilatation induced by adenosine is mediated through the activation of A2‐purinoceptors in endothelial and smooth muscle cells. 2. Adenosine induces a rapid and transient membrane hyperpolarization in endothelial cells. 3. Acute exposure to adenosine or A2‐purinoceptor agonists activates the L‐arginine‐NO signalling pathway in human endothelial cells in vitro.

[1]  L. Sobrevia,et al.  Activation of A2‐purinoceptors by adenosine stimulates L‐arginine transport (system y+) and nitric oxide synthesis in human fetal endothelial cells. , 1997, The Journal of physiology.

[2]  L. Poston,et al.  Association of gestational diabetes with abnormal maternal vascular endothelial function , 1997, British journal of obstetrics and gynaecology.

[3]  L. Sobrevia,et al.  Diabetes and insulin‐induced stimulation of L‐arginine transport and nitric oxide synthesis in rabbit isolated gastric glands. , 1997, The Journal of physiology.

[4]  G. Watts,et al.  Impaired endothelium-dependent and independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: role of dyslipidaemia. , 1996, Clinical science.

[5]  W. Graier,et al.  High D-Glucose–Induced Changes in Endothelial Ca2+/EDRF Signaling are Due to Generation of Superoxide Anions , 1996, Diabetes.

[6]  L. Rodríguez-Mañas,et al.  Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated human hemoglobin. Possible mechanisms involved. , 1996, Hypertension.

[7]  J. Marshall,et al.  Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. , 1996, The Journal of physiology.

[8]  M. Miras-Portugal,et al.  Bovine adrenal endothelial cells express nucleoside transporters nonregulated by protein kinases A and C. , 1996, The American journal of physiology.

[9]  S. Bursell,et al.  Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. , 1996, Science.

[10]  P. Rösen,et al.  Impairment of endothelium dependent relaxation in the diabetic rat heart: mechanisms and implications. , 1996, Diabetes research and clinical practice.

[11]  N. Hattori,et al.  Expression of Glucose Transporters in Rat Brain Following Transient Focal Ischemic Injury , 1996, Journal of neurochemistry.

[12]  L. Mazzanti,et al.  Activation of endothelial cells during insulin‐dependent diabetes mellitus: a biochemical and morphological study , 1996, European journal of clinical investigation.

[13]  A. Shore,et al.  Microvascular functional abnormalities in diabetes: the role of the endothelium. , 1996, Diabetes research and clinical practice.

[14]  G. King,et al.  Vitamin E Normalizes Diacylglycerol—Protein Kinase C Activation Induced by Hyperglycemia in Rat Vascular Tissues , 1996, Diabetes.

[15]  G. Garcı́a-Cardeña,et al.  Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[16]  D. Slaaf,et al.  Local 24-h hyperglycemia does not affect endothelium-dependent or -independent vasoreactivity in humans. , 1996, The American journal of physiology.

[17]  A. Baron,et al.  Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. , 1996, The Journal of clinical investigation.

[18]  Yu-jung Chen,et al.  Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated. , 1996, The American journal of physiology.

[19]  J. Williamson,et al.  LY290181, an Inhibitor of Diabetes-Induced Vascular Dysfunction, Blocks Protein Kinase C—Stimulated Transcriptional Activation Through Inhibition of Transcription Factor Binding to a Phorbol Response Element , 1996, Diabetes.

[20]  A. Keech,et al.  Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. , 1996, The Journal of clinical investigation.

[21]  S. Baumgartner-Parzer,et al.  High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase. , 1996, The Biochemical journal.

[22]  M. Creager,et al.  Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. , 1996, Journal of the American College of Cardiology.

[23]  L. Sobrevia,et al.  Activation of L‐arginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells. , 1996, The Journal of physiology.

[24]  G. D. Johnston,et al.  Impaired Vasoconstriction to Endothelin 1 in Patients With NIDDM , 1996, Diabetes.

[25]  L. Sobrevia,et al.  Diabetes‐induced activation of system y+ and nitric oxide synthase in human endothelial cells: association with membrane hyperpolarization. , 1995, The Journal of physiology.

[26]  W. Waldhäusl,et al.  High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells , 1995, Diabetes.

[27]  H. Vinters,et al.  High Expression of the Gluti Glucose Transporter in Human Brain Hemangioblastoma Endothelium , 1995, Journal of neuropathology and experimental neurology.

[28]  W. Abebe,et al.  Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. , 1995, The American journal of physiology.

[29]  E. Block,et al.  Hypoxia inhibits L-arginine uptake by pulmonary artery endothelial cells. , 1995, The American journal of physiology.

[30]  E. Reece,et al.  The Interrelationship Between Ethnicity and Gestational Diabetes in Fetal Macrosomia , 1995, Diabetes Care.

[31]  E. Cagliero,et al.  The effects of high glucose on human endothelial cell growth and gene expression are not mediated by transforming growth factor-beta. , 1995, Laboratory investigation; a journal of technical methods and pathology.

[32]  M. Creager,et al.  Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. , 1995, Circulation.

[33]  W. Mayhan,et al.  Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C. , 1995, The American journal of physiology.

[34]  G. Mann,et al.  Insulin stimulates cationic amino acid transport activity in the isolated perfused rat pancreas , 1995, Experimental physiology.

[35]  M. Kelm,et al.  Transport of L-arginine in arginine-deprived endothelial cells. , 1995, Biochemical and biophysical research communications.

[36]  P. Vallance,et al.  Vascular and hormonal responses to arginine: provision of substrate for nitric oxide or non-specific effect? , 1995, Clinical science.

[37]  J. Dobson,et al.  Adenosine enhances nitric oxide production by vascular endothelial cells. , 1995, The American journal of physiology.

[38]  J. Tooke,et al.  Pathophysiology of microvascular disease in non-insulin-dependent diabetes. , 1995, Clinical science.

[39]  D. S. Lind,et al.  TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. , 1995, Annals of surgery.

[40]  A. Donker,et al.  Endothelial Dysfunction Precedes Development of Microalbuminuria in IDDM , 1995, Diabetes.

[41]  U. Eriksson,et al.  The pathogenesis of congenital malformations in diabetic pregnancy. , 1995, Diabetes/metabolism reviews.

[42]  A. Piccoli,et al.  Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo. , 1995, The Journal of clinical endocrinology and metabolism.

[43]  G. Pieper,et al.  Amelioration by L‐Arginine of a Dysfunctional Arginine/Nitric Oxide Pathway in Diabetic Endothelium , 1995, Journal of cardiovascular pharmacology.

[44]  M. Kawano,et al.  Increased Plasma Levels of Immunoreactive Endothelin and von Willebrand Factor In NIDDM Patients , 1995, Diabetes Care.

[45]  T. Tuan,et al.  Human endothelial cells are defective in diabetic vascular disease. , 1994, The Journal of surgical research.

[46]  C. Macleod,et al.  Na(+)-independent transport (uniport) of amino acids and glucose in mammalian cells. , 1994, The Journal of experimental biology.

[47]  C. Macleod,et al.  y(+)-type cationic amino acid transport: expression and regulation of the mCAT genes. , 1994, The Journal of experimental biology.

[48]  K. Kuwabara,et al.  Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[49]  N. Fineberg,et al.  Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. , 1994, The Journal of clinical investigation.

[50]  S. Klahr,et al.  Role of arginine in health and in renal disease. , 1994, The American journal of physiology.

[51]  G. Krejs,et al.  Intracellular Mechanisms Involved in D-Glucose–Mediated Amplification of Agonist-Induced Ca2+ Response and EDRF Formation in Vascular Endothelial Cells , 1994, Diabetes.

[52]  A. Baron,et al.  Hemodynamic actions of insulin. , 1994, The American journal of physiology.

[53]  A. Burden,et al.  Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. , 1994, Clinical science.

[54]  G. Wu,et al.  Insulin stimulates glycolysis and pentose cycle activity in bovine microvascular endothelial cells. , 1994, Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology.

[55]  M. Brownlee,et al.  Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes. , 1994, The Journal of clinical investigation.

[56]  C. G. Olthof,et al.  Plasma endothelin levels and vascular effects of intravenous L-arginine infusion in subjects with uncomplicated insulin-dependent diabetes mellitus. , 1994, Clinical science.

[57]  L. Sobrevia,et al.  Adenosine transport in cultured human umbilical vein endothelial cells is reduced in diabetes. , 1994, The American journal of physiology.

[58]  V. Ramkumar,et al.  Adenosine acts as an endogenous activator of the cellular antioxidant defense system. , 1994, Biochemical and biophysical research communications.

[59]  R. North,et al.  Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. , 1994, The Journal of biological chemistry.

[60]  J. Russell,et al.  Endothelium-dependent relaxations to adenosine in juvenile rabbit pulmonary arteries and veins. , 1994, The American journal of physiology.

[61]  R. Busse,et al.  Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications. , 1994, The Biochemical journal.

[62]  F. Dai,et al.  Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. , 1994, The American journal of physiology.

[63]  B. Tesfamariam.  Free radicals in diabetic endothelial cell dysfunction. , 1994, Free radical biology & medicine.

[64]  H. Kung,et al.  Hormonal regulation of the gene for the type C ecotropic retrovirus receptor in rat liver cells , 1994, Journal of virology.

[65]  S Moncada,et al.  Nitric oxide synthases in mammals. , 1994, The Biochemical journal.

[66]  J. Finlayson,et al.  High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells. , 1994, Investigative ophthalmology & visual science.

[67]  P. Taylor,et al.  Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline‐induced contractility in mesenteric resistance arteries from streptozotocin‐induced diabetic rats , 1994, British journal of pharmacology.

[68]  P. Groop,et al.  Inhibition of nitric oxide synthesis in forearm vasculature of insulin-dependent diabetic patients: blunted vasoconstriction in patients with microalbuminuria. , 1993, Clinical science.

[69]  W. Bauman,et al.  Inhibition of platelet aggregation and the stimulation of prostacyclin synthesis by insulin in humans. , 1993, The American journal of physiology.

[70]  G. Wu,et al.  Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cells. , 1993, The American journal of physiology.

[71]  M. Creager,et al.  Impaired Endothelium‐Dependent Vasodilation in Patients With Insulin‐Dependent Diabetes Mellitus , 1993, Circulation.

[72]  A. Dornhorst,et al.  Gestational Diabetes: A Challenge For The Future , 1993, Diabetic medicine : a journal of the British Diabetic Association.

[73]  J. Cunningham,et al.  Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins. , 1993, The Journal of biological chemistry.

[74]  B. Rotoli,et al.  Characterization of amino acid transport in human endothelial cells. , 1993, The American journal of physiology.

[75]  T. Wascher,et al.  Exposure To Elevated D-Glucose Concentrations Modulates Vascular Endothelial Cell Vasodilatory Response , 1993, Diabetes.

[76]  W. Walters,et al.  Vascular actions of purines in the foetal circulation of the human placenta , 1993, British journal of pharmacology.

[77]  G. Wu,et al.  The activation of the arginine-citrulline cycle in macrophages from the spontaneously diabetic BB rat. , 1993, The Biochemical journal.

[78]  G. Pinna,et al.  Plasma endothelin in essential hypertension and diabetes mellitus. , 1993, Journal of human hypertension.

[79]  M. F. Ethier,et al.  Adenosine stimulates proliferation of human endothelial cells in culture. , 1993, The American journal of physiology.

[80]  P. Angelos,et al.  Alteration of ATPase Activity and Duplex DNA in Corneal Cells Grown in High Glucose Media , 1993, Cornea.

[81]  M. Kavanaugh.  Voltage dependence of facilitated arginine flux mediated by the system y+ basic amino acid transporter. , 1993, Biochemistry.

[82]  W. Pardridge,et al.  Glucose Deprivation Causes Posttranscriptional Enhancement of Brain Capillary Endothelial Glucose Transporter Gene Expression via GLUT1 mRNA Stabilization , 1993, Journal of neurochemistry.

[83]  E. Closs,et al.  Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes , 1993, Journal of virology.

[84]  Philip S. Yu,et al.  Oxidative Deamination of Methylamine by Semicarbazide-Sensitive Amine Oxidase Leads to Cytotoxic Damage in Endothelial Cells: Possible Consequences for Diabetes , 1993, Diabetes.

[85]  B. Halliwell,et al.  The role of oxygen radicals in human disease, with particular reference to the vascular system. , 1993, Haemostasis.

[86]  M. Mcdaniel,et al.  Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation , 1993, Diabetes.

[87]  P. Smits,et al.  Endothelium-Dependent Vascular Relaxation in Patients With Type I Diabetes , 1993, Diabetes.

[88]  D. Moller,et al.  Differential Regulation of Glucose Transport and Transporters by Glucose in Vascular Endothelial and Smooth Muscle Cells , 1993, Diabetes.

[89]  P. Vallance,et al.  Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. , 1992, The Journal of clinical investigation.

[90]  H. Ito,et al.  An oxidative mechanism is involved in high glucose-induced serum protein modification causing inhibition of endothelial cell proliferation. , 1992, Atherosclerosis.

[91]  P. Taylor,et al.  Endothelium‐dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocin‐induced diabetic rats , 1992, British journal of pharmacology.

[92]  N. Ruderman,et al.  Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. , 1992, The Journal of clinical investigation.

[93]  S. O'Rourke,et al.  Bioassay of endothelium-derived relaxing factor in diabetic rat aorta. , 1992, The American journal of physiology.

[94]  C. Boyd,et al.  Identification of a new transport system (y+L) in human erythrocytes that recognizes lysine and leucine with high affinity. , 1992, The Journal of physiology.

[95]  S. Ogawa,et al.  Hypoxia induces glucose transporter expression in endothelial cells. , 1992, The American journal of physiology.

[96]  G. Pieper,et al.  Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. , 1992, The American journal of physiology.

[97]  R. Challiss,et al.  Characterization of the adenosine receptor modulating insulin action in rat skeletal muscle. , 1992, European journal of pharmacology.

[98]  S. Moncada,et al.  Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter , 1992, British journal of pharmacology.

[99]  M. Mcdaniel,et al.  Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction , 1992, Diabetes.

[100]  J. D. Salvo,et al.  Human Retinal Vascular Cells Differ from Umbilical Cells in Synthetic Functions and Their Response to Glucose , 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[101]  D. W. Cheung,et al.  Characterization of acetylcholine-induced membrane hyperpolarization in endothelial cells. , 1992, Circulation research.

[102]  H. Drexler,et al.  Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine , 1991, The Lancet.

[103]  M. Loeken,et al.  Stimulation of endothelin-1 gene expression by insulin in endothelial cells. , 1991, The Journal of biological chemistry.

[104]  S. Moncada,et al.  Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells. , 1991, Biochemical and biophysical research communications.

[105]  E. Friedman,et al.  Advanced glycosylation end products in patients with diabetic nephropathy. , 1991, The New England journal of medicine.

[106]  R. North,et al.  Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter , 1991, Nature.

[107]  J. Cunningham,et al.  Transport of cationic amino acids by the mouse ecotropic retrovirus receptor , 1991, Nature.

[108]  J. Ritter,et al.  Vascular responsiveness and cation exchange in insulin-dependent diabetes. , 1991, Clinical science.

[109]  A. Paoletti,et al.  Early alterations of Gi/Go protein‐dependent transductional processes in the retina of diabetic animals , 1991, Journal of neuroscience research.

[110]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[111]  W. Souba,et al.  Characterization of L-arginine transport by pulmonary artery endothelial cells. , 1991, The American journal of physiology.

[112]  J. Cooke,et al.  Arginine Restores Cholinergic Relaxation of Hypercholesterolemic Rabbit Thoracic Aorta , 1991, Circulation.

[113]  K. Tracey,et al.  Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. , 1991, The Journal of clinical investigation.

[114]  R. Spahr,et al.  Metabolism of exogenous substrates by coronary endothelial cells in culture. , 1990, Journal of molecular and cellular cardiology.

[115]  J. Vane,et al.  The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[116]  J. Daut,et al.  The electrical response of cultured guinea‐pig coronary endothelial cells to endothelium‐dependent vasodilators. , 1990, The Journal of physiology.

[117]  J. Vane,et al.  The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[118]  J. Slot,et al.  No evidence for expression of the Insulin-regulatable glucose transporter in endothelial cells , 1990, Nature.

[119]  U. Eriksson,et al.  Effects of Maternal Diabetes on Placental Transfer of Glucose in Rats , 1990, Diabetes.

[120]  D. Lang,et al.  Release of endothelium‐derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester , 1990, British journal of pharmacology.

[121]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[122]  J. Pearson,et al.  Protein kinase C activation alters the sensitivity of agonist-stimulated endothelial-cell prostacyclin production to intracellular Ca2+. , 1989, The Biochemical journal.

[123]  G. King,et al.  Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[124]  J. Pearson,et al.  Expression of amino acid transport systems in cultured human umbilical vein endothelial cells. , 1989, The Journal of physiology.

[125]  J. LaManna,et al.  Vascular Perfusion and Blood‐Brain Glucose Transport in Acute and Chronic Hyperglycemia , 1988, Journal of neurochemistry.

[126]  R. Wohlhueter,et al.  Nucleoside and nucleobase transport in animal cells. , 1988, Biochimica et biophysica acta.

[127]  R. Taylor,et al.  The biochemistry of diabetes. , 1988, The Biochemical journal.

[128]  M. Gerritsen,et al.  Glucose starvation is required for insulin stimulation of glucose uptake and metabolism in cultured microvascular endothelial cells. , 1988, Microvascular research.

[129]  M. Porta,et al.  High glucose concentrations inhibit DNA synthesis and replication without causing death or impairing injury repair in cultured human endothelial cells. , 1988, Diabetes research.

[130]  D. Godin,et al.  Alterations in Free Radical Tissue-Defense Mechanisms in Streptozocin-Induced Diabetes in Rat: Effects of Insulin Treatment , 1987, Diabetes.

[131]  S. Toledo,et al.  Myo-inositol enhances the proliferation of human endothelial cells in culture but fails to prevent the delay induced by high glucose. , 1986, Metabolism: clinical and experimental.

[132]  P. Vanhoutte,et al.  Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. , 1986, The American journal of physiology.

[133]  A. Barbul.  Arginine: biochemistry, physiology, and therapeutic implications. , 1986, JPEN. Journal of parenteral and enteral nutrition.

[134]  H. Bardenheuer,et al.  Supply-to-demand ratio for oxygen determines formation of adenosine by the heart. , 1986, The American journal of physiology.

[135]  M. F. White.  The transport of cationic amino acids across the plasma membrane of mammalian cells. , 1985, Biochimica et biophysica acta.

[136]  M. Gerritsen,et al.  Insulin Binding and Effects of Insulin on Glucose Uptake and Metabolism in Cultured Rabbit Coronary Microvessel Endothelium , 1985, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[137]  B. Metzger,et al.  Gestational Diabetes Mellitus: Correlations Between the Phenotypic and Genotypic Characteristics of the Mother and Abnormal Glucose Tolerance During the First Year Postpartum , 1985, Diabetes.

[138]  M. Kilberg,et al.  Induction and decay of amino acid transport in the liver. Turnover of transport activity in isolated hepatocytes after stimulation by diabetes or glucagon. , 1984, The Journal of biological chemistry.

[139]  S. Buchwald,et al.  Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels. , 1983, The Journal of clinical investigation.

[140]  A. Gjedde,et al.  Blood-brain glucose transfer: repression in chronic hyperglycemia. , 1981, Science.

[141]  E. Kohner,et al.  Twenty-four hour variations of von Willebrand factor and factor VIII-related antigen in diabetic retinopathy. , 1981, Metabolism: clinical and experimental.

[142]  R. Gleason,et al.  Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. , 1981, The New England journal of medicine.

[143]  A. Moawad,et al.  Amniotic fluid C-peptide as an index for intrauterine fetal growth. , 1981, American journal of obstetrics and gynecology.

[144]  Farris K. Timimi,et al.  Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. , 1996, The Journal of clinical investigation.

[145]  J. Pearson,et al.  Regulation of L‐arginine transport and nitric oxide release in superfused porcine aortic endothelial cells. , 1996, The Journal of physiology.

[146]  M. Kilberg,et al.  Molecular biology of mammalian amino acid transporters. , 1996, Annual review of biochemistry.

[147]  A. Spiegel,et al.  Defects in G protein-coupled signal transduction in human disease. , 1996, Annual review of physiology.

[148]  J. Pearson,et al.  Vessel wall interactions regulating thrombosis. , 1994, British medical bulletin.

[149]  H. Takahashi,et al.  Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients. , 1993, Thrombosis research.

[150]  S. Wolff.  Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. , 1993, British medical bulletin.

[151]  R. Cohen,et al.  DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS , 1993 .

[152]  R. S. Bar.  Vascular Endothelium and Diabetes Mellitus , 1992 .

[153]  M. Grant,et al.  Plasminogen activator production by human retinal endothelial cells of nondiabetic and diabetic origin. , 1991, Investigative ophthalmology & visual science.

[154]  J. Pearson,et al.  Cardiovascular purinoceptors. , 1990, Physiological reviews.

[155]  L. Ignarro.  Biosynthesis and metabolism of endothelium-derived nitric oxide. , 1990, Annual review of pharmacology and toxicology.

[156]  M. Abe,et al.  Effects of glucose and insulin on cultured human microvascular endothelial cells. , 1990, Diabetes research and clinical practice.

[157]  G. Milligan,et al.  Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes , 1987, Nature.

[158]  Mara,et al.  High glucose induces DNA damage in cultured human endothelial cells. , 1986, The Journal of clinical investigation.

[159]  J. Schrader,et al.  Measurement of adenosine, inosine, and hypoxanthine in human plasma. , 1984, Journal of chromatography.