Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis

[1]  P. Sikiric,et al.  Intragastric Application of Aspirin, Clopidogrel, Cilostazol, and BPC 157 in Rats: Platelet Aggregation and Blood Clot , 2019, Oxidative medicine and cellular longevity.

[2]  L. Deng,et al.  Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction , 2019, NPG Asia Materials.

[3]  Z. Hussain,et al.  Novel biodegradable pH-sensitive hydrogels: An efficient controlled release system to manage ulcerative colitis. , 2019, International journal of biological macromolecules.

[4]  M. Huang,et al.  Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation , 2019, Oxidative medicine and cellular longevity.

[5]  N. E. El Sayed,et al.  Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways , 2019, Archives of Toxicology.

[6]  M. Neurath,et al.  Resolution of ulcerative colitis , 2019, Seminars in Immunopathology.

[7]  H. Ouyang,et al.  A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds , 2019, Nature Communications.

[8]  Vladimir P. Torchilin,et al.  Hydrogels and Their Applications in Targeted Drug Delivery , 2019, Molecules.

[9]  Siddharth Singh,et al.  AGA Technical Review on the Management of Mild-to-Moderate Ulcerative Colitis. , 2019, Gastroenterology.

[10]  Jin Qi,et al.  An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair , 2019, NPG Asia Materials.

[11]  Jin-Wook Yoo,et al.  A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model , 2018, Drug design, development and therapy.

[12]  H. Santos,et al.  Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration , 2018, Advanced science.

[13]  Dohoon Kim,et al.  Therapeutic switching of sulpiride, an anti-psychotic and prokinetic drug, to an anti-colitic drug using colon-specific drug delivery , 2018, Drug Delivery and Translational Research.

[14]  S. Ryu,et al.  Mechanisms regulating intestinal barrier integrity and its pathological implications , 2018, Experimental & Molecular Medicine.

[15]  Yiyun Cheng,et al.  A Nanocomposite Hydrogel with Potent and Broad-Spectrum Antibacterial Activity. , 2018, ACS applied materials & interfaces.

[16]  G. Rogler,et al.  The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation , 2018, Journal of Crohn's & colitis.

[17]  Mudassir,et al.  pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation , 2018, Drug Delivery and Translational Research.

[18]  Aaron W. Miller,et al.  Intestinal Epithelial Cell–Derived LKB1 Suppresses Colitogenic Microbiota , 2018, The Journal of Immunology.

[19]  Van Thu Le,et al.  Low systemic toxicity nanocarriers fabricated from heparin-mPEG and PAMAM dendrimers for controlled drug release. , 2018, Materials science & engineering. C, Materials for biological applications.

[20]  Hyo-Jin An,et al.  Comparative Evaluation between Sulfasalazine Alone and in Combination with Herbal Medicine on DSS-Induced Ulcerative Colitis Mice , 2017, BioMed research international.

[21]  M. Eroglu,et al.  Novel levan and pNIPA temperature sensitive hydrogels for 5-ASA controlled release. , 2017, Carbohydrate polymers.

[22]  K. Papadakis,et al.  Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics , 2017, Gut and liver.

[23]  I. G. Clausen,et al.  Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications , 2017, Scandinavian journal of gastroenterology.

[24]  S. Lerouge,et al.  Mucoadhesive chitosan hydrogels as rectal drug delivery vessels to treat ulcerative colitis. , 2017, Acta biomaterialia.

[25]  D. Greaves,et al.  A novel real time imaging platform to quantify macrophage phagocytosis , 2016, Biochemical pharmacology.

[26]  M. Qiao,et al.  The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells , 2016, International journal of nanomedicine.

[27]  S. Hanauer Oral or Topical 5-ASA in Ulcerative Colitis , 2016, Digestive Diseases.

[28]  Shuzhao Li,et al.  The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation , 2016, Nature.

[29]  Ke Wang,et al.  Novel pH-sensitive hydrogels for 5-aminosalicylic acid colon targeting delivery: in vivo study with ulcerative colitis targeting therapy in mice , 2015, Drug delivery.

[30]  E. Elinav,et al.  Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis , 2015, Cell.

[31]  Z. Jia,et al.  The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice. , 2015, International immunopharmacology.

[32]  Y. Magata,et al.  Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[33]  A. Caminade,et al.  The key role of the scaffold on the efficiency of dendrimer nanodrugs , 2015, Nature Communications.

[34]  Robert Langer,et al.  An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease , 2015, Science Translational Medicine.

[35]  Elazer R. Edelman,et al.  Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia , 2015, Science Translational Medicine.

[36]  J. Smart Theories of Mucoadhesion , 2014 .

[37]  S. Knowles,et al.  Safety of 5-Aminosalicylic Acid Derivatives in Patients with Sensitivity to Acetylsalicylic Acid and Nonsteroidal Anti-inflammatory Drugs. , 2014, The Canadian journal of hospital pharmacy.

[38]  M. Bryszewska,et al.  Surface modification of PAMAM dendrimer improves its biocompatibility. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[39]  Burr J. Loew,et al.  Foam preparations for the treatment of ulcerative colitis. , 2012, Current drug delivery.

[40]  Subrata Ghosh,et al.  Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. , 2012, Gastroenterology.

[41]  D. Zamboni,et al.  A Method for Generation of Bone Marrow-Derived Macrophages from Cryopreserved Mouse Bone Marrow Cells , 2010, PloS one.

[42]  P. Kesharwani,et al.  Dendrimer toxicity: Let's meet the challenge. , 2010, International journal of pharmaceutics.

[43]  Quan Guo,et al.  Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients , 2010, Journal of experimental & clinical cancer research : CR.

[44]  M. Kastan,et al.  The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. , 2010, Immunity.

[45]  D. Owczarek,et al.  Biological therapy of inflammatory bowel disease. , 2009, Polskie Archiwum Medycyny Wewnetrznej.

[46]  M. Kamm,et al.  Review article: 5‐aminosalicylate formulations for the treatment of ulcerative colitis – methods of comparing release rates and delivery of 5‐aminosalicylate to the colonic mucosa , 2008, Alimentary pharmacology & therapeutics.

[47]  T. Murata,et al.  Anti‐inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice , 2008, British journal of pharmacology.

[48]  A. Lavy,et al.  Clinical trial: randomized‐controlled clinical study comparing the efficacy and safety of a low‐volume vs. a high‐volume mesalazine foam in active distal ulcerative colitis , 2007, Alimentary pharmacology & therapeutics.

[49]  Y. Barenholz,et al.  Local treatment of experimental colitis in the rat by negatively charged liposomes of catalase, TMN and SOD , 2006, Journal of drug targeting.

[50]  J. Varshosaz,et al.  Colon-specific delivery of mesalazine chitosan microspheres , 2006, Journal of microencapsulation.

[51]  G. Mooter Colon drug delivery , 2006 .

[52]  M. Adeli,et al.  Dendrimers of citric acid and poly (ethylene glycol) as the new drug-delivery agents. , 2005, Biomaterials.

[53]  Y. Barenholz,et al.  Differential Adhesion of Normal and Inflamed Rat Colonic Mucosa by Charged Liposomes , 2004, Pharmaceutical Research.

[54]  M. Bogataj,et al.  The correlation between zeta potential and mucoadhesion strength on pig vesical mucosa. , 2003, Biological & pharmaceutical bulletin.

[55]  R. Wiwattanapatapee,et al.  Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[56]  K. G. Eboes Histopathology of Crohn's Disease and Ulcerative Colitis , 2003 .

[57]  Tsutomu Suzuki,et al.  Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[58]  B. Gertz,et al.  A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis , 2002, Alimentary pharmacology & therapeutics.

[59]  Margus,et al.  Efficacy and tolerability of mesalazine foam enema (Salofalk foam) for distal ulcerative colitis: a double‐blind, randomized, placebo‐controlled study , 2000, Alimentary pharmacology & therapeutics.

[60]  M. Cotten,et al.  Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus , 2000, Gene Therapy.

[61]  S. Riley What dose of 5-aminosalicylic acid (mesalazine) in ulcerative colitis? , 1998, Gut.

[62]  T. Ohkusa,et al.  A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice , 1990 .

[63]  C. FordAlexander,et al.  ULCERATIVE colitis. , 1997, Journal of the American Medical Association.