Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.

[1]  L. Squire,et al.  Comparison of metabolic rates, language, and memory in subcortical aphasias , 1983, Brain and Language.

[2]  M. Kinsbourne,et al.  A model for the mechanism of unilateral neglect of space. , 1970, Transactions of the American Neurological Association.

[3]  M E Phelps,et al.  Patterns of human local cerebral glucose metabolism during epileptic seizures. , 1982, Science.

[4]  E Tulving,et al.  Retrograde Amnesia in Free Recall , 1969, Science.

[5]  Kenneth M. Heilman,et al.  Frontal lobe neglect in man , 1972, Neurology.

[6]  M E Raichle,et al.  Positron emission tomography and its application to the study of cerebrovascular disease in man. , 1985, Stroke.

[7]  K. Welch,et al.  Experimental production of unilateral neglect in monkeys. , 1958, Brain : a journal of neurology.

[8]  C. Bruce,et al.  Primate frontal eye fields. I. Single neurons discharging before saccades. , 1985, Journal of neurophysiology.

[9]  E. Winograd,et al.  Retrograde amnesia and priority instructions in free recall. , 1970, Journal of experimental psychology.

[10]  W. Paschen,et al.  Multiparametric Imaging of Blood Flow and Metabolism after Middle Cerebral Artery Occlusion in Cats , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  W. Heiss,et al.  Comparative Studies of Regional CNS Blood Flow and Evoked Potentials in the Cat: Effects of Hypotensive Ischemia on Somatosensory Evoked Potentials in Cerebral Cortex and Spinal Cord , 1984, Stroke.

[12]  P. Goldman-Rakic.  Topography of cognition: parallel distributed networks in primate association cortex. , 1988, Annual review of neuroscience.

[13]  A. Levey,et al.  Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey , 1983, The Journal of comparative neurology.

[14]  A. C. Eycleshymer,et al.  A cross-section anatomy , 1970 .

[15]  M. Mesulam.  A cortical network for directed attention and unilateral neglect , 1981, Annals of neurology.

[16]  E. Grastyán,et al.  Hippocampal electrical activity during the development of conditioned reflexes. , 1959, Electroencephalography and clinical neurophysiology.

[17]  R A Margolin,et al.  Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. , 1983, Brain : a journal of neurology.

[18]  S Zeger,et al.  Relationship of somatosensory evoked potentials and cerebral oxygen consumption during hypoxic hypoxia in dogs. , 1986, Stroke.

[19]  Kenneth M. Heilman,et al.  Hemispatial neglect affected by non‐neglected stimuli , 1988, Neurology.

[20]  J Y Chang,et al.  Two behavioral states studied in a single PET/FDG procedure: theory, method, and preliminary results. , 1987, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  D Comar,et al.  Crossed cerebellar diaschisis. Further studies. , 1986, Brain : a journal of neurology.

[22]  L. Sokoloff,et al.  Human brain glucose utilization and cognitive function in relation to age , 1984, Annals of neurology.

[23]  D. Pandya,et al.  Cortico-cortical connections in the rhesus monkey. , 1969, Brain research.

[24]  Brenda Milner,et al.  Visual recognition and recall after right temporal-lobe excision in man , 1968 .

[25]  D. Loewenstein,et al.  Behavioral Activation and the Variability of Cerebral Glucose Metabolic Measurements , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  D. Pandya,et al.  Some observations on the course and composition of the cingulum bundle in the rhesus monkey , 1984, The Journal of comparative neurology.

[27]  F Mauguiere,et al.  The duality of the cingulate gyrus in monkey. Neuroanatomical study and functional hypothesis. , 1980, Brain : a journal of neurology.