MONOCLONAL ANTIBODIES THAT REACT PREFERENTIALLY WITH FIBRINOGEN DEGRADATION PRODUCTS OR WITH CROSS‐LINKED FIBRIN SPLIT PRODUCTS

(1) In the screening test, the ability of the antibody to bind to undegraded fibrinogen, fibrinogen degradation products (isolated fragments D or E), or to fibrin split products immobilized on polystyrene wells was analyzed. (2) In the competitive binding assay, the ability of fibrinogen, fibrinogen degradation products (fragment D or fragment E) or fibrin degradation products to inhibit the binding of selected monoclonal antibodies to the fragment D or the fragment E polystyrene coated wells was tested.