JLX001 improves myocardial ischemia-reperfusion injury by activating Jak2-Stat3 pathway.

[1]  Jun Zhou,et al.  The Role of Janus Kinase/Signal Transducer and Activator of Transcription Signalling on Preventing Intestinal Ischemia/Reperfusion Injury with Dexmedetomidine. , 2020, Journal of nanoscience and nanotechnology.

[2]  G. Wong,et al.  The timing of propofol administration affects the effectiveness of remote ischemic preconditioning induced cardioprotection in rats , 2020, Journal of cellular biochemistry.

[3]  M. Warren,et al.  Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma , 2020, Cell Death & Disease.

[4]  Ping Yang,et al.  Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury through mTOR signal pathway. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[5]  Hong Gao,et al.  Urolithin B improves cardiac function and reduces susceptibility to ventricular arrhythmias in rats after myocardial infarction. , 2020, European journal of pharmacology.

[6]  M. Galagudza,et al.  Effect of Combined Antimicrobial Therapy on Ischemia/Reperfusion Myocardial Injury in Rats with Acute Inflammation of the Large Intestine against the Background of Alimentary Obesity , 2020, Bulletin of Experimental Biology and Medicine.

[7]  E. Allahyari,et al.  The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery , 2019, Brazilian journal of cardiovascular surgery.

[8]  Jinyong Peng,et al.  Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro , 2019, Oxidative medicine and cellular longevity.

[9]  Zengenni Liang,et al.  Betulinic Acid Attenuates T-2-Toxin-Induced Testis Oxidative Damage Through Regulation of the JAK2/STAT3 Signaling Pathway in Mice , 2019, Biomolecules.

[10]  A. Ahangarpour,et al.  Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation. , 2019, Pharmacological reports : PR.

[11]  Yun-Man Li,et al.  Therapeutic effects of JLX-001 on ischemic stroke by inducing autophagy via AMPK-ULK1 signaling pathway in rats , 2019, Brain Research Bulletin.

[12]  Yunman Li,et al.  JLX001 Modulated the Inflammatory Reaction and Oxidative Stress in pMCAO Rats via Inhibiting the TLR2/4-NF-κB Signaling Pathway , 2019, Neurochemical Research.

[13]  Lehe Yang,et al.  Aminocyanopyridines as anti‐lung cancer agents by inhibiting the STAT3 pathway , 2019, Molecular carcinogenesis.

[14]  Xuedan Wang,et al.  Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b , 2019, Medical science monitor : international medical journal of experimental and clinical research.

[15]  Weijian Huang,et al.  Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes , 2019, Drug design, development and therapy.

[16]  Jianping Yang,et al.  microRNA‐874 inhibition targeting STAT3 protects the heart from ischemia–reperfusion injury by attenuating cardiomyocyte apoptosis in a mouse model , 2018, Journal of cellular physiology.

[17]  Thomas J. Hund,et al.  &bgr;IV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload , 2018, The Journal of clinical investigation.

[18]  T. Csont,et al.  Effects of Cardiovascular Risk Factors on Cardiac STAT3 , 2018, International journal of molecular sciences.

[19]  Yuanrong Ju,et al.  N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia , 2018, Medicine.

[20]  W. Fang,et al.  Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[21]  M. Roccia,et al.  Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based , 2018, Front. Immunol..

[22]  F. Fang,et al.  Exogenous hydrogen sulfide ameliorates high glucose‐induced myocardial injury & inflammation via the CIRP‐MAPK signaling pathway in H9c2 cardiac cells , 2018, Life sciences.

[23]  X. Sun,et al.  Role of Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in cardioprotection of exercise preconditioning. , 2018, European review for medical and pharmacological sciences.

[24]  Fei Xie,et al.  TWEAK/Fn14 mediates atrial‐derived HL‐1 myocytes hypertrophy via JAK2/STAT3 signalling pathway , 2018, Journal of cellular and molecular medicine.

[25]  L. Piegas,et al.  Ticagrelor vs Clopidogrel After Fibrinolytic Therapy in Patients With ST-Elevation Myocardial Infarction: A Randomized Clinical Trial , 2018, JAMA cardiology.

[26]  T. Miura,et al.  Does p53 Inhibition Suppress Myocardial Ischemia–Reperfusion Injury? , 2018, Journal of cardiovascular pharmacology and therapeutics.

[27]  S. Cadenas ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection. , 2018, Free radical biology & medicine.

[28]  A. El‐kott,et al.  Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling , 2018, Basic Research in Cardiology.

[29]  You Zhou,et al.  Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro , 2017, Redox biology.

[30]  Chun-yang Li,et al.  Inhibition of the SOCS1-JAK2-STAT3 Signaling Pathway Confers Neuroprotection in Rats with Ischemic Stroke , 2017, Cellular Physiology and Biochemistry.

[31]  E. Gao,et al.  Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3‐dependent regulation of oxidative stress and apoptosis , 2017, Journal of pineal research.

[32]  T. Fukutomi,et al.  Dynamics of Oxidative Stress Evoked by Myocardial Ischemia Reperfusion After Off-Pump Coronary Artery Bypass Grafting Elucidated by Bilirubin Oxidation. , 2017, Circulation journal : official journal of the Japanese Circulation Society.

[33]  Yang Zm,et al.  Fas/FasL induces myocardial cell apoptosis in myocardial ischemia-reperfusion rat model. , 2017 .

[34]  Chenglin Zhang,et al.  PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction , 2017, Scientific Reports.

[35]  A. Akhmedov,et al.  Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression , 2017, Cardiovascular research.

[36]  X-K Liu,et al.  Fas/FasL induces myocardial cell apoptosis in myocardial ischemia-reperfusion rat model. , 2017, European review for medical and pharmacological sciences.

[37]  H. Thomas,et al.  The JAK/STAT pathway in obesity and diabetes , 2016, The FEBS journal.

[38]  S. Peng,et al.  JAK2/STAT3 Pathway Mediates Protection of Metallothionein Against Doxorubicin-Induced Cytotoxicity in Mouse Cardiomyocytes , 2016, International journal of toxicology.

[39]  C. Vergely,et al.  Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse. , 2015, Clinical science.

[40]  Yan Zhang,et al.  Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy. , 2015, American journal of physiology. Heart and circulatory physiology.

[41]  A. Ottani,et al.  Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest. , 2014, European journal of pharmacology.

[42]  H. Watari,et al.  Apoptosis and Molecular Targeting Therapy in Cancer , 2014, BioMed research international.

[43]  M. Pesu,et al.  Therapeutic targeting of the Jak/STAT pathway. , 2014, Basic & clinical pharmacology & toxicology.

[44]  C. Montessuit,et al.  JAK-STAT signaling and myocardial glucose metabolism , 2013, JAK-STAT.

[45]  N. Shahrokhi,et al.  The Effect of Saffron Consumption on Biochemical and Histopathological Heart Indices of Rats with Myocardial Infarction , 2010, Cardiovascular Toxicology.

[46]  H. Drexler,et al.  Many good reasons to have STAT3 in the heart. , 2005, Pharmacology & therapeutics.