论文信息 - The chemistry of pyrazine and its derivatives. X. The mono- and diacylation of tetramethylpyrazine

The chemistry of pyrazine and its derivatives. X. The mono- and diacylation of tetramethylpyrazine

By the use of sodium amide in liquid ammonia or phenyllithium in ether as the condensing agent it has been possible to synthesize a series of ketones containing the pyrazine ring with the structure, RCOCH2C4N2(CH3)3 where R is alkyl, aryl or heterocyclic. Also, under appropriate conditions, tetramethylpyrazine has been diacylated to give three diketones of the type (2-RCOCH2)-(6-R' COCH2)C4N2(CH3)2-3, 5.

S. Chakrabartty | R. Levine

[1] M. R. Kamal,et al. The Chemistry of Pyrazine and Its Derivatives. VIII. Diketones Derived from the Monoacylation of 2-Methyl-6-(acylmethyl)pyrazines and the Diacylation of 2,6-Dimethylpyrazine1 , 1964 .

[2] M. Neubert,et al. The Chemistry of Pyrazine and Its Derivatives. VII. The Synthesis of Vinylpyrazine and Substituted Vinylpyrazines1 , 1962 .

[3] M. R. Kamal,et al. The Chemistry of Pyrazine and Its Derivatives. VI. The Synthesis of Carbinols Containing the Pyrazine Nucleus1 , 1962 .

[4] M. R. Kamal,et al. Chemistry of Pyrazine and Its Derivatives. V. Acylation and Alkylation of 2,6-Dimethylpyrazine and Certain Other Pyrazine Derivatives1 , 1962 .

[5] R. Levine,et al. The Chemistry of Pyrazine and Its Derivatives. IV. The Alkylation and Arylation of Methylpyrazine1 , 1961 .

[6] R. Levine,et al. Chemistry of Pyrazine and Its Derivatives. III. The Synthesis of Carbinols by the Participation of Methylpyrazine in Aldol-type Condensations1 , 1959 .

[7] R. Levine,et al. The Chemistry of Pyrazine and its Derivatives. II. The Acylation of Methylpyrazine1 , 1959 .

[8] R. Levine,et al. Chemistry of Pyrazine and its Derivatives. I. The Hypohalite Oxidation of Acetonyl- and Phenacylpyrazine1 , 1958 .