Two Dutch brothers with Borrone dermato‐cardio‐skeletal syndrome

In 1993, Borrone et al. described two Italian brothers affected by a syndrome of severe acne, mitral valve prolapse, dysmorphic facies, and Scheuermann‐like changes of the vertebral column. Since then, no further cases have been reported. Here, we report on two Dutch brothers with many features suggestive of this rare syndrome. © 2007 Wiley‐Liss, Inc.