Association between Obesity and Chronic Laryngitis in Women – Data from the Korea National Health and Nutrition Examination Survey

Background: This study aimed to investigate the relationship between obesity and chronic laryngitis in South Korea using data from the Korea National Health and Nutrition Examination Surveys (KNHANES) collected during 2008-2010. Methods: KNHANES was a cross-sectional survey of the civilian, non-institutionalized population of South Korea (n = 13,819). Obesity status was measured by using BMI and waist circumference. Results: Among the population over 19 years of age, the prevalence of chronic laryngitis was 4.0 ± 0.4%. Chronic laryngitis was significantly associated with age, BMI, waist circumference, fat proportion, both systolic and diastolic blood pressure, fasting blood sugar, triglycerides, and high-density lipoprotein cholesterol in women. Old age and current smoking were significantly associated with chronic laryngitis in men. Obese women were at a higher risk for chronic laryngitis than women without obesity (odds ratio (OR) 2.022, 95% confidence interval (95% CI) 1.412-2.895) after further adjustment for confounders. Women with abdominal obesity were also at higher risk for chronic laryngitis (OR 1.475, 95% CI 1.024-2.126). Conclusion: Obese women in Korea have an elevated risk for developing chronic laryngitis. Further epidemiological and experimental studies are necessary to clarify the impact of obesity on this condition.

[1]  Kyungwon Oh,et al.  Data Resource Profile: The Korea National Health and Nutrition Examination Survey (KNHANES) , 2014, International journal of epidemiology.

[2]  J. Noordzij,et al.  Incidence of Chronic Laryngitis , 2013, The Annals of otology, rhinology, and laryngology.

[3]  Scott M Langevin,et al.  Gastric Reflux Is an Independent Risk Factor for Laryngopharyngeal Carcinoma , 2013, Cancer Epidemiology, Biomarkers & Prevention.

[4]  M. Fox,et al.  The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro‐oesophageal reflux disease , 2013, Alimentary pharmacology & therapeutics.

[5]  Yangho Kim,et al.  Inappropriate Survey Design Analysis of the Korean National Health and Nutrition Examination Survey May Produce Biased Results , 2013, Journal of preventive medicine and public health = Yebang Uihakhoe chi.

[6]  H. A. Park.  The Korea National Health and Nutrition Examination Survey as a Primary Data Source , 2013, Korean journal of family medicine.

[7]  P. Thornley,et al.  Laryngeal tuberculosis: A case of a non-healing laryngeal lesion. , 2012, The Australasian medical journal.

[8]  Jesper Lagergren,et al.  Influence of obesity on the risk of esophageal disorders , 2011, Nature Reviews Gastroenterology &Hepatology.

[9]  K. Bitar,et al.  Aging and gastrointestinal neuromuscular function: insights from within and outside the gut , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[10]  J. Andrews,et al.  Lower esophageal sphincter relaxation is impaired in older patients with dysphagia. , 2011, World journal of gastroenterology.

[11]  B. Cosman,et al.  Obesity epidemiology. , 2011, Clinics in colon and rectal surgery.

[12]  Zsófia Osváth,et al.  DOI: 10 , 2011 .

[13]  Ambady Ramachandran,et al.  Rising Burden of Obesity in Asia , 2010, Journal of obesity.

[14]  Hyun-Young Park,et al.  Dietary carbohydrate intake is associated with cardiovascular disease risk in Korean: analysis of the third Korea National Health and Nutrition Examination Survey (KNHANES III). , 2010, International journal of cardiology.

[15]  A. Merati.  Acute and Chronic Laryngitis , 2010 .

[16]  N. Talley.  The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease , 2009 .

[17]  A. Yen,et al.  The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease , 2008, Gut.

[18]  H. El‐Serag.  The Association Between Obesity and GERD: A Review of the Epidemiological Evidence , 2008, Digestive Diseases and Sciences.

[19]  H. Jung,et al.  Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case–control study of 7078 Koreans undergoing health check-ups , 2008, Gut.

[20]  J. Dworkin.  Laryngitis: types, causes, and treatments. , 2008, Otolaryngologic clinics of North America.

[21]  N. Pedersen,et al.  Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins. , 2008, Gastroenterology.

[22]  E. Cholongitas,et al.  Gastro-oesophageal reflux disease and irritable bowel syndrome significantly associated with metabolic syndrome , 2008, Scandinavian journal of gastroenterology.

[23]  T. Imai,et al.  Association between reflux oesophagitis and features of the metabolic syndrome in Japan , 2007, Alimentary pharmacology & therapeutics.

[24]  M. Vaezi,et al.  Laryngeal disorders in patients with gastroesophageal reflux disease. , 2007, Minerva Gastroenterologica e Dietologica.

[25]  K. L. Goh,et al.  Gastro‐oesophageal reflux disease in chronic laryngitis: prevalence and response to acid‐suppressive therapy , 2006, Alimentary pharmacology & therapeutics.

[26]  K. Paunović,et al.  Chronic laryngitis in glassblowers. , 2005, Industrial health.

[27]  K. Hveem,et al.  Obesity and estrogen as risk factors for gastroesophageal reflux symptoms. , 2003, JAMA.

[28]  R. Shaker,et al.  Effect of chronic and acute cigarette smoking on the pharyngoglottal closure reflex , 2002, Gut.

[29]  J. Koufman.  Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. , 2002, Ear, nose, & throat journal.

[30]  J. Koufman,et al.  Laryngopharyngeal Reflux: Position Statement of the Committee on Speech, Voice, and Swallowing Disorders of the American Academy of Otolaryngology-Head and Neck Surgery , 2002, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[31]  J. Lagergren,et al.  Body Mass and Reflux Oesophagitis: an Oestrogen-dependent Association? , 2002, Scandinavian journal of gastroenterology.

[32]  J. Stemple,et al.  Shifts in relative prevalence of laryngeal pathology in a treatment-seeking population. , 2001, Journal of voice : official journal of the Voice Foundation.

[33]  R. Shaker,et al.  Effect of chronic and acute cigarette smoking on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow , 1998, Gut.

[34]  J. Koufman.  The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): A Clinical Investigation of 225 Patients Using Ambulatory 24‐Hour pH Monitoring and an Experimental Investigation of the Role of Acid and Pepsin in the Development of Laryngeal Injury , 1991, The Laryngoscope.

[35]  L. Hill,et al.  Effect of obesity on esophageal transit. , 1985, American journal of surgery.