Inhibiting vitamin A metabolism as an approach to male contraception

[1]  M. Griswold,et al.  Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. , 2011, Journal of andrology.

[2]  T. Plant.  Undifferentiated primate spermatogonia and their endocrine control , 2010, Trends in Endocrinology & Metabolism.

[3]  D. Cyr,et al.  Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes , 2010, Microscopy research and technique.

[4]  M. Griswold,et al.  The key role of vitamin A in spermatogenesis. , 2010, The Journal of clinical investigation.

[5]  M. Sukhwani,et al.  Spermatogonial stem cells in higher primates: are there differences from those in rodents? , 2010, Reproduction.

[6]  V. Laudet,et al.  From carrot to clinic: an overview of the retinoic acid signaling pathway , 2010, Cellular and Molecular Life Sciences.

[7]  B. Tarlatzis,et al.  The use of hormonal contraception and its protective role against endometrial and ovarian cancer. , 2010, Best practice & research. Clinical obstetrics & gynaecology.

[8]  D. Cyr,et al.  Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: Changes in spermatid organelles associated with development of spermatozoa , 2009, Microscopy research and technique.

[9]  Xiangyuan Wang,et al.  Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis , 2009, Development.

[10]  D. Bok,et al.  Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation. , 2008, Reproduction.

[11]  David C Page,et al.  Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice , 2008, Proceedings of the National Academy of Sciences.

[12]  R. P. Amann.  The cycle of the seminiferous epithelium in humans: a need to revisit? , 2008, Journal of andrology.

[13]  K. Kraemer,et al.  Are low tolerable upper intake levels for vitamin A undermining effective food fortification efforts? , 2008, Nutrition reviews.

[14]  W. Bremner,et al.  Advances in male contraception. , 2008, Endocrine reviews.

[15]  T. J. Doyle,et al.  Potential Functions of Retinoic Acid Receptor A in Sertoli Cells and Germ Cells During Spermatogenesis , 2007, Annals of the New York Academy of Sciences.

[16]  Josephine Bowles,et al.  Retinoic acid, meiosis and germ cell fate in mammals , 2007, Development.

[17]  M. Zhang,et al.  Altered vitamin A homeostasis and increased size and adiposity in the rdhl‐null mouse , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Vasilis Vasiliou,et al.  Multiple and Additive Functions of ALDH3A1 and ALDH1A1 , 2007, Journal of Biological Chemistry.

[19]  Min Zhang,et al.  Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. , 2007, Biochimica et biophysica acta.

[20]  Anne E Carpenter,et al.  In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication , 2006, Nature Genetics.

[21]  S. Schlatt,et al.  A revised model for spermatogonial expansion in man: lessons from non-human primates. , 2006, Reproduction.

[22]  M. Heilig,et al.  Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. , 2006, Pharmacology & therapeutics.

[23]  G. Duester,et al.  Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning , 2006, Development.

[24]  P. Chambon,et al.  RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation , 2006, The Journal of experimental medicine.

[25]  David C Page,et al.  Retinoic acid regulates sex-specific timing of meiotic initiation in mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Edwards,et al.  Functional Characterization of Mouse RDH11 as a Retinol Dehydrogenase Involved in Dark Adaptation in Vivo* , 2005, Journal of Biological Chemistry.

[27]  V. Giguère,et al.  Alveolarization in Retinoic Acid Receptor-β–Deficient Mice , 2005, Pediatric Research.

[28]  M. Griswold,et al.  Profiling Gene Expression During the Differentiation and Development of the Murine Embryonic Gonad1 , 2005, Biology of reproduction.

[29]  M. Griswold,et al.  The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1 , 2004, Biology of reproduction.

[30]  T. Noda,et al.  Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta , 2004, Nature Genetics.

[31]  G. van der Horst,et al.  Short-term effects of N'N-bis(dichloroacetyl)-1,8-octamethylenediamine (WIN 18446) on the testes, selected sperm parameters and fertility of male CBA mice , 2003, Laboratory animals.

[32]  P. Chambon,et al.  Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[33]  V. Crotet,et al.  The so-called "testis-specific aldehyde dehydrogenase" corresponds to type 2 retinaldehyde dehydrogenase in the mouse , 2003, Histochemistry and Cell Biology.

[34]  G. Livera,et al.  Regulation and perturbation of testicular functions by vitamin A. , 2002, Reproduction.

[35]  J. L. Napoli,et al.  Cellular expression of retinal dehydrogenase types 1 and 2: Effects of vitamin A status on testis mRNA , 2001, Journal of cellular physiology.

[36]  K. Kim,et al.  Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal development: identification of potential heterodimeric receptors. , 1999, Biology of reproduction.

[37]  G. Duester,et al.  Metabolic Deficiencies in Alcohol Dehydrogenase Adh1,Adh3, and Adh4 Null Mutant Mice , 1999, The Journal of Biological Chemistry.

[38]  P. Chambon,et al.  Retinoid X receptors are essential for early mouse development and placentogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[39]  D. Higgins,et al.  Coexpression of the mRNAs encoding retinol dehydrogenase isozymes and cellular retinol‐binding protein , 1997, Journal of cellular physiology.

[40]  L. López-Fernández,et al.  The cytosolic aldehyde dehydrogenase gene (Aldh1) is developmentally expressed in Leydig cells , 1997, FEBS letters.

[41]  K. Kim,et al.  Retinoic acid receptor alpha gene expression in the rat testis: potential role during the prophase of meiosis and in the transition from round to elongating spermatids. , 1997, Biology of reproduction.

[42]  P Chambon,et al.  RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[43]  C. Klaassen,et al.  Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[44]  M. Nishimura,et al.  Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes. , 2006, Drug metabolism and pharmacokinetics.

[45]  P. Chambon,et al.  Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis. , 2006, Endocrinology.

[46]  M. O’Bryan,et al.  Cytology of the testis and intrinsic control mechanisms , 2006 .

[47]  V. Giguère,et al.  Alveolarization in retinoic acid receptor-beta-deficient mice. , 2005, Pediatric research.

[48]  S. Ohkura,et al.  Physiology of Reproduction , 2000 .

[49]  G. Duester,et al.  Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice. , 1999, Developmental genetics.

[50]  R. Haselbeck,et al.  Localization of class I and class IV alcohol dehydrogenases in mouse testis and epididymis: potential retinol dehydrogenases for endogenous retinoic acid synthesis. , 1997, Biology of reproduction.