Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis.

PURPOSE To compare optical coherence tomography (OCT) with fundus fluorescein angiography (FFA) for the detection of cystoid macular edema (CME) in patients with uveitis. DESIGN Prospective comparative observational series. PARTICIPANTS One hundred twenty-one eyes of 58 patients with uveitis of varied causes (seven patients were studied twice). TESTING Patients with suspected CME underwent OCT scanning followed by FFA at the same visit. MAIN OUTCOME MEASURES Detection and distribution of macular edema. RESULTS One hundred eight eyes had similar results on both OCT and FFA in that 67 eyes had CME and 41 eyes had no CME. In 10 eyes subretinal fluid was detected on OCT but not FFA. Five of these eyes had CME on FFA but not OCT. Three other eyes had CME that was detected by FFA but not by OCT. Compared with FFA, the OCT sensitivity for detecting CME was 96% (including the eyes with subretinal fluid), and the OCT specificity was 100%. CONCLUSIONS OCT is as effective at detecting CME as is FFA but is superior in demonstrating axial distribution of fluid.

[1]  Eric A. Swanson,et al.  Optical Coherence Tomography of Macular Holes , 1996 .

[2]  J. Duker,et al.  Imaging of macular diseases with optical coherence tomography. , 1995, Ophthalmology.

[3]  S. Vernon,et al.  Volumetric analysis of early macular edema with the Heidelberg Retina Tomograph in diabetic retinopathy. , 1998, Ophthalmology.

[4]  J. Fujimoto,et al.  Optical coherence tomography of the human retina. , 1995, Archives of ophthalmology.

[5]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[6]  E. Chew,et al.  A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. , 1996, Ophthalmology.

[7]  Eric A. Swanson,et al.  Quantitative Assessment of Macular Edema With Optical Coherence Tomography , 1995 .

[8]  L. Yannuzzi,et al.  Chronic cystoid macular edema and predictors of visual acuity. , 1993, Ophthalmic surgery.

[9]  F L Ferris,et al.  Macular thickening and visual acuity. Measurement in patients with cystoid macular edema. , 1987, Ophthalmology.

[10]  E Reichel,et al.  Optical coherence tomography of central serous chorioretinopathy. , 1995, American journal of ophthalmology.

[11]  J. Duker,et al.  Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. , 1996, Ophthalmology.

[12]  H. Schatz,et al.  Nausea from fluorescein angiography. , 1982, American journal of ophthalmology.

[13]  R Birngruber,et al.  Argon laser retinal lesions evaluated in vivo by optical coherence tomography. , 1997, American journal of ophthalmology.

[14]  J. Duker,et al.  Optical coherence tomography of macular lesions associated with optic nerve head pits. , 1996, Ophthalmology.

[15]  A. Elsner,et al.  Quantification of cystoid changes in diabetic maculopathy. , 1995, Investigative ophthalmology & visual science.

[16]  S. Asrani,et al.  A new method for rapid mapping of the retinal thickness at the posterior pole. , 1996, Investigative ophthalmology & visual science.

[17]  R Birngruber,et al.  A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy. , 1997, Archives of ophthalmology.

[18]  R. E. Smith,et al.  Complications of chronic cyclitis. , 1976, American journal of ophthalmology.

[19]  M. Shahidi,et al.  Retinal thickness analysis for quantitative assessment of diabetic macular edema. , 1991, Archives of ophthalmology.

[20]  R S Sobel,et al.  Fluorescein angiography complication survey. , 1986, Ophthalmology.

[21]  L. Yannuzzi.  A perspective on the treatment of aphakic cystoid macular edema. , 1984, Survey of ophthalmology.

[22]  E Reichel,et al.  Topography of diabetic macular edema with optical coherence tomography. , 1998, Ophthalmology.

[23]  A. Fercher,et al.  In vivo optical coherence tomography. , 1993, American journal of ophthalmology.

[24]  J B Walsh,et al.  Imaging congenital optic disc pits and associated maculopathy using optical coherence tomography. , 1996, Archives of ophthalmology.

[25]  C. W. Parker,et al.  Reactions following intravenous fluorescein. , 1971, American journal of ophthalmology.

[26]  E Reichel,et al.  Characterization of epiretinal membranes using optical coherence tomography. , 1996, Ophthalmology.

[27]  A C Bird,et al.  Confocal imaging of the fundus using a scanning laser ophthalmoscope. , 1992, The British journal of ophthalmology.

[28]  R. Penner,et al.  Anaphylactoid reaction to intravenously administered fluorescein. , 1968, Archives of ophthalmology.