Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke – induced pulmonary injury and emphysema

[1]  Alvar Agusti,et al.  Immunologic aspects of chronic obstructive pulmonary disease. , 2009, The New England journal of medicine.

[2]  Ze'ev Ronai,et al.  REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase , 2009, EMBO reports.

[3]  N. Hay,et al.  mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition , 2009, Molecular and Cellular Biology.

[4]  S. Ryter,et al.  Autophagy in chronic obstructive pulmonary disease: Homeostatic or pathogenic mechanism? , 2009, Autophagy.

[5]  M. Sporn,et al.  Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice , 2009, Proceedings of the National Academy of Sciences.

[6]  I. Fidler,et al.  Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse , 2008, Journal of Biological Chemistry.

[7]  K. Stuhlmeier,et al.  The TSC-mTOR signaling pathway regulates the innate inflammatory response. , 2008, Immunity.

[8]  S. Ryter,et al.  Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1 , 2008, Autophagy.

[9]  C. D. Dela Cruz,et al.  Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. , 2008, The Journal of clinical investigation.

[10]  D. Sgroi,et al.  Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. , 2008, Genes & development.

[11]  M. Maines,et al.  Biliverdin inhibits activation of NF‐κB: Reversal of inhibition by human biliverdin reductase , 2007, International journal of cancer.

[12]  G. Hortobagyi,et al.  IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway , 2007, Cell.

[13]  Toshinori Yoshida,et al.  Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. , 2007, Physiological reviews.

[14]  H. Coxson,et al.  Antielastin autoimmunity in tobacco smoking–induced emphysema , 2007, Nature Medicine.

[15]  H Phillip Koeffler,et al.  RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation. , 2007, Experimental hematology.

[16]  P. Mahadevan,et al.  An overview , 2007, Journal of Biosciences.

[17]  T. Flotte,et al.  α-1 Antitrypsin Inhibits Caspase-3 Activity, Preventing Lung Endothelial Cell Apoptosis , 2006 .

[18]  W. Arap,et al.  State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. , 2006, Proceedings of the American Thoracic Society.

[19]  R. Homer,et al.  State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. , 2006, Proceedings of the American Thoracic Society.

[20]  G. Kroemer,et al.  Current development of mTOR inhibitors as anticancer agents , 2006, Nature Reviews Drug Discovery.

[21]  I. Adcock,et al.  Oxidative stress and redox regulation of lung inflammation in COPD , 2006, European Respiratory Journal.

[22]  I. Douglas,et al.  Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. , 2006, Chest.

[23]  A. Lilja,et al.  Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[24]  S. Reddy,et al.  A Phosphatidylinositol 3-Kinase-regulated Akt-Independent Signaling Promotes Cigarette Smoke-induced FRA-1 Expression* , 2006, Journal of Biological Chemistry.

[25]  A. M. Houghton,et al.  Elastin fragments drive disease progression in a murine model of emphysema. , 2006, The Journal of clinical investigation.

[26]  A. Kraneveld,et al.  A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation , 2006, Nature Medicine.

[27]  T. Flotte,et al.  alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. , 2006, The American journal of pathology.

[28]  Xianglin Shi,et al.  Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein. , 2005, The Biochemical journal.

[29]  C. Johannessen,et al.  Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1 , 2005, Molecular and Cellular Biology.

[30]  D. Hicklin,et al.  Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development. , 2005, American journal of respiratory cell and molecular biology.

[31]  I. Petrache,et al.  Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice , 2005, Nature Medicine.

[32]  K. Inoki,et al.  The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway* , 2005, Journal of Biological Chemistry.

[33]  K. Inoki,et al.  Signaling by Target of Rapamycin Proteins in Cell Growth Control , 2005, Microbiology and Molecular Biology Reviews.

[34]  E. Hafen,et al.  The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. , 2004, Genes & development.

[35]  E. Hafen,et al.  Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. , 2004, Genes & development.

[36]  N. Perkins,et al.  Post-translational modification of RelA(p65) NF-κB , 2004 .

[37]  M. Cosio,et al.  The development of emphysema in cigarette smoke-exposed mice is strain dependent. , 2004, American journal of respiratory and critical care medicine.

[38]  Irina Petrache,et al.  Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. , 2004, The Journal of clinical investigation.

[39]  P. Einat,et al.  Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. , 2004, Investigative ophthalmology & visual science.

[40]  T. Hunter,et al.  Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies , 2004, Current Biology.

[41]  Irfan Rahman,et al.  Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. , 2004, American journal of respiratory cell and molecular biology.

[42]  A. Zampetaki,et al.  Hypoxia induces macrophage inflammatory protein‐2 (MIP‐2) gene expression in murine macrophages via NF‐κB: the prominent role of p42/ p44 and PI3 kinase pathways , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  D. Briggs,et al.  An Evolutionary Perspective , 2004, J. Decis. Syst..

[44]  N. Perkins,et al.  Post-translational modification of RelA(p65) NF-kappaB. , 2004, Biochemical Society transactions.

[45]  J. Howell,et al.  A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets* , 2003, Journal of Biological Chemistry.

[46]  N. Voelkel,et al.  Apoptosis and emphysema: the missing link. , 2003, American journal of respiratory cell and molecular biology.

[47]  A. Churg,et al.  Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. , 2003, American journal of respiratory and critical care medicine.

[48]  N. Voelkel,et al.  Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. , 2003, American journal of respiratory cell and molecular biology.

[49]  A. Trifilieff,et al.  In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. , 2003, American journal of respiratory and critical care medicine.

[50]  中平 毅一.  Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity , 2003 .

[51]  L. Najjar.  The missing link. , 2003, Dental assistant.

[52]  A. Yang,et al.  REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. , 2002, Molecular cell.

[53]  Christine C. Hudson,et al.  Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin , 2002, Molecular and Cellular Biology.

[54]  W. MacNee,et al.  4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. , 2002, American journal of respiratory and critical care medicine.

[55]  Dena Leshkowitz,et al.  Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis , 2002, Molecular and Cellular Biology.

[56]  Peter Neuhaus,et al.  mTOR inhibitors: An overview , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[57]  R. Tiernan,et al.  Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. , 2000, The New England journal of medicine.

[58]  M. Stern,et al.  Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. , 2000, The New England journal of medicine.

[59]  Shi,et al.  Regulation of macrophage inflammatory protein‐2 gene expression by oxidative stress in rat alveolar macrophages , 1999, Immunology.

[60]  D. Brenner,et al.  NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. , 1998, The Journal of clinical investigation.

[61]  S. Shapiro,et al.  Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. , 1997, Science.

[62]  T. Flotte,et al.  Adeno-associated virus vectors for gene therapy. , 1995, Gene therapy.

[63]  J. Whitsett,et al.  Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.