Differential distribution of D3 dopamine receptors in the brains of several mammalian species

The D3 dopamine receptor has been proposed as a potential target for the treatment of schizophrenia and drug abuse. This study compares the distribution of D3 sites in mouse, rat, guinea pig, and rabbit brain, and dog and human cerebellum using quantitative autoradiography with the putatively selective D3 receptor radioligand [3H]PD 128907. In the mouse, rat, guinea pig, and rabbit, specific [3H]PD 128907 binding was heterogeneously distributed with highest densities observed in the islands of Calleja, followed by the nucleus accumbens. Moderate densities of [3H]PD 128907 binding were observed in the anteroventral and dorsomedial caudate nucleus. Dense [3H]PD 128907-labelled sites were observed in the dorsal thalamus, posterior mamilliary nucleus, and dorsomedial interpeduncular nucleus of the rabbit that were not detected in the other species studied. Moderately dense []PD 128907 binding was also observed in the molecular layer of cerebellar lobule X of the rat but not in the mouse, guinea pig, rabbit, dog, or human. These observations indicate significant inter-species differences in the distribution of D3 receptors.

[1]  B. Levant.  The D3 dopamine receptor: neurobiology and potential clinical relevance. , 1997, Pharmacological reviews.

[2]  Lars Farde,et al.  Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907 , 1996, Psychopharmacology.

[3]  R. Beaurepaire,et al.  Evidence for a functional role of the dopamine D3 receptors in the cerebellum , 1996, Brain Research.

[4]  E. Richfield,et al.  Comparative distribution of dopamine D‐1 and D‐2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys , 1987, The Journal of comparative neurology.

[5]  Bruno Giros,et al.  Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics , 1990, Nature.

[6]  Differential pharmacological profile of striatal and cerebellar dopamine receptors labeled by [3H]quinpirole: Identification of a discrete population of putative D3 receptors , 1993, Synapse.

[7]  Bruno Giros,et al.  Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA , 1991, Brain Research.

[8]  H. Wikström,et al.  Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells. , 1995, Life sciences.

[9]  J. Stevens.  An anatomy of schizophrenia? , 1973, Archives of general psychiatry.

[10]  G. Vauquelin,et al.  Autoradiographic distribution of D3-type dopamine receptors in human brain using [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin , 1994, Brain Research.

[11]  C. Tamminga,et al.  D2-Family receptor distribution in human postmortem tissue: an autoradiographic study , 1995, Neuroreport.

[12]  S. B. Caine,et al.  Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. , 1993, Science.

[13]  W. Greenough,et al.  A stereotaxic atlas of the albino mouse forebrain. , 1980 .

[14]  J. Joyce,et al.  Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrain. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[15]  D. Grigoriadis,et al.  Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain. , 1992, The Journal of pharmacology and experimental therapeutics.

[16]  G. N. Bancroft,et al.  Binding of [3H]PD 128907, a Putatively Selective Ligand for the D3 Dopamine Receptor, in Rat Brain: A Receptor Binding and Quantitative Autoradiographic Study , 1998, Neuropsychopharmacology.

[17]  Stanley J. Watson,et al.  The rat brain in stereotaxic coordinates (2nd edn) by George Paxinos and Charles Watson, Academic Press, 1986. £40.00/$80.00 (264 pages) ISBN 012 547 6213 , 1987, Trends in Neurosciences.

[18]  T. J. Luparello.  Stereotaxic atlas of the forebrain of the guinea pig = Stereotaktischer Atlas des Vorderhirns des Meerschweinchens = Atlas stéréotaxique du cerveau antérieur du cobaye = Atlas estereotáxico del cerebro anterior del cobaya , 1967 .