Possible Genetical Pathways for the Biosynthesis of Blood Group Mucopolysaccharides

Certain aspects of the biochemistry and genetics of the human A, B, H and Lea blood group characters are reviewed and, on the basis of the biochemical and genetical data, possible pathways are outlined for the biosynthesis of the water‐soluble mucopolysaccharides which possess blood group specificity.

[1]  E. Franklin,et al.  Some genetical implications of physical studies of human haptoglobins. , 1958, Science.

[2]  H. H. Baer,et al.  Die Konstitution der Lacto-N-fucopentaose II. Ein Beitrag zur Spezifität der Blutgruppensubstanz Lea , 1958 .

[3]  R. Kuhn,et al.  Über die Lacto‐Difuco‐Tetraose Der Frauenmilch. Ein Beitrag zur Strukturspezifität der Blutgruppensubstanz Le , 1958 .

[4]  M. Stacey,et al.  699. Immunopolysaccharides. Part X. The structure of the immunologically specific polysaccharide of pneumococcus type XIV , 1958 .

[5]  W. Morgan,et al.  Specific Inhibition Studies Relating to the Lewis Blood-Group System , 1957, Nature.

[6]  R. Whistler,et al.  The biosynthesis of hyaluronic acid. , 1957, Advances in carbohydrate chemistry.

[7]  W. Watkins,et al.  Role of a D-glucosamine as Inhibitor of the Precipitation of Blood Group Substances by Anti-Type XIV Pneumococcus Serum , 1956, Nature.

[8]  W. Whelan The synthesis and degradation of polysaccharides. , 1956, Lectures on the scientific basis of medicine.

[9]  W. Morgan,et al.  Some Nitrogen-containing Disaccharides isolated from Human Blood-Group A Substance , 1956, Nature.

[10]  W. Watkins,et al.  The Product of the Human Blood Group A and B Genes in Individuals Belonging to Group AB , 1956, Nature.

[11]  S. Iseki,et al.  On Bacterial Enzyme Specifically Decomposing Group B Substance , 1956 .

[12]  O. Makela,et al.  Leb antigen; studies on its occurrence in red cells, plasma and saliva. , 1956, Annales medicinae experimentalis et biologiae Fenniae.

[13]  W. Morgan,et al.  The A and H character of the blood group substances secreted by persons belonging to group A2. , 1956, Acta genetica et statistica medica.

[14]  E. Kabat,et al.  Immunochemical Studies on Blood Groups. XVII. Structural Units Involved in Blood Group A and B Specificity1 , 1955 .

[15]  P. Sneath,et al.  Transformation of the Lewis Groups of Human Red Cells , 1955, Nature.

[16]  R. A. Gibbons,et al.  Studies in immunochemistry. 16. The isolation of blood-group active mucoids from ovarian cyst fluids. , 1955, The Biochemical journal.

[17]  W. Watkins,et al.  Inhibition by Simple Sugars of Enzymes Which Decompose the Blood-Group Substances , 1955, Nature.

[18]  W. Morgan The chemical basis of blood group specificity in man. , 1959, Lectures on the scientific basis of medicine.

[19]  W. Morgan,et al.  The inhibition of the haemagglutinins in plant seeds by human blood group substances and simple sugars. , 1953, British journal of experimental pathology.

[20]  S. Iseki,et al.  Transformation of Blood Group Substance by Bacterial Enzyme , 1953 .

[21]  W. Morgan,et al.  Neutralization of the Anti-H Agglutinin in Eel Serum by Simple Sugars , 1952, Nature.

[22]  R. Grubb Observations on the human group system Lewis. , 2009, Acta pathologica et microbiologica Scandinavica.

[23]  R. Grubb Correlation between Lewis Blood Group and Secretor Character in Man , 1948, Nature.

[24]  E. Kabat,et al.  IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS VII. CHEMICAL CHANGES ASSOCIATED WITH DESTRUCTION OF BLOOD GROUP ACTIVITY AND ENHANCEMENT OF THE TYPE XIV CROSS-REACTIVITY BY PARTIAL HYDROLYSIS OF HOG AND HUMAN BLOOD GROUP A, B, AND O SUBSTANCES , 1948 .

[25]  E. Kabat,et al.  IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS VI. THE CROSS-REACTION BETWEEN TYPE XIV ANTIPNEUMOCOCCAL HORSE SERUM AND PURIFIED BLOOD GROUP A, B, AND O SUBSTANCES FROM HOG AND HUMAN SOURCES , 1948 .

[26]  W. Morgan,et al.  The detection of a product of the blood group O gene and the relationship of the so-called O-substance to the agglutinates A and B. , 1948, British journal of experimental pathology.

[27]  K. Boorman,et al.  A serum which demonstrates the co-dominance of the blood-group gene O with A and B. , 1948, Annals of eugenics.

[28]  N. C. Klendshoj,et al.  THE ISOLATION OF AN O SPECIFIC SUBSTANCE FROM GASTRIC JUICE OF SECRETORS AND CARBOHYDRATE-LIKE SUBSTANCES FROM GASTRIC JUICE OF NON-SECRETORS , 1941, The Journal of experimental medicine.

[29]  P. Beeson,et al.  THE IMMUNOLOGICAL RELATIONSHIP OF THE CAPSULAR POLYSACCHARIDE OF TYPE XIV PNEUMOCOCCUS TO THE BLOOD GROUP A SPECIFIC SUBSTANCE , 1939, The Journal of experimental medicine.