THE EFFECT OF AGEING ON RNA/DNA RATIOS IN BRAIN REGIONS OF THE C57BL/6J MALE MOUSE

—The effect of ageing on RNA/DNA was investigated in brain regions and liver of a healthy subpopulation of C57BL/6J male mice. A decrease of 10% in RNA/DNA was found in senescent striatum in contrast to absence of significant change in the hypothalamus, cerebellum, hippocampus, septum and liver.

[1]  R. I. Lin,et al.  Micro estimation of RNA by the cupric ion catalyzed orcinol reaction. , 1969, Analytical biochemistry.

[2]  C. Barrows,et al.  Enzymatic studies in senescent rodent brains. , 1968, Journal of gerontology.

[3]  K. Burton A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. , 1956, The Biochemical journal.

[4]  B. Wostmann,et al.  Aging in germ-free mice: life tables and lesions observed at natural death. , 1966, Journal of gerontology.

[5]  C. Finch,et al.  Retardation of hair regrowth, a phenomenon of senescence in C57B1-6J male mice. , 1973, Journal of gerontology.

[6]  U. Ringborg Composition and content of RNA in neurons of rat hippocampus at different ages. , 1966, Brain research.

[7]  C. Finch,et al.  Catecholamine metabolism in the brains of ageing male mice. , 1973, Brain research.

[8]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[9]  V. J. Wulff,et al.  Age-related reduction of the RNA content of rat cardiac muscle and cerebellum. , 1961, Archives of biochemistry and biophysics.

[10]  J. Ferrendelli,et al.  REGIONAL ENERGY METABOLISM AND LIPOFUSCIN ACCUMULATION IN MOUSE BRAIN DURING AGING , 1971, Journal of neuropathology and experimental neurology.

[11]  B. Mcewen,et al.  PROPERTIES OF CELL NUCLEI ISOLATED FROM VARIOUS REGIONS OF RAT BRAIN: DIVERGENT CHARACTERISTICS OF CEREBELLAR CELL NUCLEI , 1972, Journal of neurochemistry.

[12]  J R Foster,et al.  Ageing and the Regulation of Cell Activities during Exposure to Cold , 1969, The Journal of general physiology.