Allogeneic ABCB5+ Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial

[1]  A. Kerstan,et al.  Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data , 2020, Cytotherapy.

[2]  K. Scharffetter-Kochanek,et al.  Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing , 2020, Frontiers in Cell and Developmental Biology.

[3]  Julia Pieper,et al.  Process data of allogeneic ex vivo-expanded ABCB5+ mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP , 2020, Stem cell research & therapy.

[4]  J. Karp,et al.  Shattering barriers toward clinically meaningful MSC therapies , 2020, Science Advances.

[5]  C. Bullen,et al.  Wool-derived keratin dressings versus usual care dressings for treatment of slow healing venous leg ulceration: a randomised controlled trial (Keratin4VLU) , 2020, BMJ Open.

[6]  J. Kasza,et al.  Associations between patient, treatment, or wound‐level factors and venous leg ulcer healing: Wound characteristics are the key factors in determining healing outcomes , 2020, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[7]  C. McCollum,et al.  A pilot multi‐centre prospective randomised controlled trial of RECELL for the treatment of venous leg ulcers , 2020, International wound journal.

[8]  N. Arsenijević,et al.  The role of Interleukin 1 receptor antagonist in mesenchymal stem cell‐based tissue repair and regeneration , 2019, BioFactors.

[9]  Filipa F. Ferreira,et al.  Newly Defined ATP‐Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron‐Overload Wounds via Secretion of Interleukin‐1 Receptor Antagonist , 2019, Stem cells.

[10]  A. Kerstan,et al.  In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials , 2019, Cytotherapy.

[11]  A. Caplan.  Cell‐Based Therapies: The Nonresponder , 2018, Stem cells translational medicine.

[12]  L. Dubois,et al.  Summaries of Recent Phlebological Abstracts , 2018, Phlebology.

[13]  A. Palmer,et al.  The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes , 2018, Front. Physiol..

[14]  G. Tew,et al.  Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial† , 2018, The British journal of dermatology.

[15]  A. Reyzelman,et al.  A multicentre randomised controlled trial evaluating the efficacy of dehydrated human amnion/chorion membrane (EpiFix®) allograft for the treatment of venous leg ulcers , 2017, International wound journal.

[16]  R. Snyder,et al.  Randomized Controlled Trial Comparing Collagen/Oxidized Regenerated Cellulose/Silver to Standard of Care in the Management of Venous Leg Ulcers , 2017, Advances in skin & wound care.

[17]  E. FifeCaroline,et al.  Publicly Reported Wound Healing Rates: The Fantasy and the Reality , 2017 .

[18]  C. Jackson,et al.  Inflammation in Chronic Wounds , 2016, International journal of molecular sciences.

[19]  J. Raffetto.  Pathophysiology of wound healing and alterations in venous leg ulcers-review , 2016, Phlebology.

[20]  H. Edwards,et al.  Risk factors for delayed healing in venous leg ulcers: a review of the literature , 2015, International journal of clinical practice.

[21]  W. Marston,et al.  Management of venous leg ulcers: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum Endorsed by the American College of Phlebology and the Union Internationale de Phlébologie , 2014 .

[22]  J. Dumville,et al.  Clinical and cost-effectiveness of compression hosiery versus compression bandages in treatment of venous leg ulcers (Venous leg Ulcer Study IV, VenUS IV): a randomised controlled trial , 2014, The Lancet.

[23]  M. Courtney,et al.  The effectiveness of a four‐layer compression bandage system in comparison with Class 3 compression hosiery on healing and quality of life in patients with venous leg ulcers: a randomised controlled trial , 2014, International Wound Journal.

[24]  C. Lok,et al.  Prognostic factors associated with healing of venous leg ulcers: a multicentre, prospective, cohort study , 2013, The British journal of dermatology.

[25]  Martina Mueller,et al.  A randomized, investigator-blinded, controlled pilot study to evaluate the safety and efficacy of a poly-N-acetyl glucosamine-derived membrane material in patients with venous leg ulcers. , 2012, Journal of the American Academy of Dermatology.

[26]  S. Khan,et al.  Factors Associated with Poor Healing and Recurrence of Venous Ulceration , 2012, Plastic and reconstructive surgery.

[27]  Lee J. Markowitz,et al.  Wounds measured from digital photographs using photodigital planimetry software: validation and rater reliability. , 2011, Wounds : a compendium of clinical research and practice.

[28]  Cord Sunderkötter,et al.  An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. , 2011, The Journal of clinical investigation.

[29]  C. Gabay,et al.  IL-1 pathways in inflammation and human diseases , 2010, Nature Reviews Rheumatology.

[30]  D. Gemmati,et al.  DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators. , 2009, Journal of vascular surgery.

[31]  D. Bogdanović,et al.  Risk factors related to the failure of venous leg ulcers to heal with compression treatment. , 2009, Journal of Vascular Surgery.

[32]  R. Kirsner,et al.  A gene signature of nonhealing venous ulcers: potential diagnostic markers. , 2008, Journal of the American Academy of Dermatology.

[33]  D. Gemmati,et al.  Clinical implications of gene polymorphisms in venous leg ulcer: A model in tissue injury and reparative process , 2007, Thrombosis and Haemostasis.

[34]  M. Gohel,et al.  The Ulcerated Leg Severity Assessment score for prediction of venous leg ulcer healing , 2007 .

[35]  S. Tognazzo,et al.  Prognostic role of factor XIII gene variants in nonhealing venous leg ulcers. , 2006, Journal of vascular surgery.

[36]  A. Sassano,et al.  Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial , 2004, The Lancet.

[37]  D. Margolis,et al.  The accuracy of venous leg ulcer prognostic models in a wound care system , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[38]  M. Sayegh,et al.  Regulation of Progenitor Cell Fusion by ABCB5 P-glycoprotein, a Novel Human ATP-binding Cassette Transporter* , 2003, Journal of Biological Chemistry.

[39]  D. Margolis,et al.  Surrogate endpoints for the treatment of venous leg ulcers. , 2002, The Journal of investigative dermatology.

[40]  R. Taylor,et al.  Using an artificial neural network to predict healing times and risk factors for venous leg ulcers. , 2002, Journal of wound care.

[41]  V. Falanga,et al.  Prognostic indicators in venous ulcers. , 2000, Journal of the American Academy of Dermatology.

[42]  D. Margolis,et al.  Which venous leg ulcers will heal with limb compression bandages? , 2000, The American journal of medicine.

[43]  A. Davies,et al.  Venous ulcer healing by four‐layer compression bandaging is not influenced by the pattern of venous incompetence , 1999, The British journal of surgery.

[44]  D. Margolis,et al.  Risk factors associated with the failure of a venous leg ulcer to heal. , 1999, Archives of dermatology.

[45]  D. Margolis,et al.  Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group. , 1998, Archives of dermatology.

[46]  S. Werner,et al.  Wound repair and regeneration , 1994, Nature.

[47]  J J Dale,et al.  Chronic ulcer of the leg: clinical history. , 1987, British medical journal.

[48]  R. Kirsner,et al.  Wound healing society 2015 update on guidelines for venous ulcers , 2016, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[49]  M. Streit,et al.  S3-Guideline on Venous Leg Ulcer Developed by the Guideline Subcommittee ‘Diagnostics and Treatment of Venous Leg Ulcers’ of the European Dermatology Forum , 2016 .

[50]  T. Phillips,et al.  Early healing rates and wound area measurements are reliable predictors of later complete wound closure , 2008, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[51]  J. Earnshaw,et al.  Risk factors for delayed healing and recurrence of chronic venous leg ulcers--an analysis of 1324 legs. , 2005, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[52]  S. Meaume,et al.  Prognostic factors for venous ulcer healing in a non-selected population of ambulatory patients. , 2005, Journal of wound care.

[53]  R. Polignano,et al.  A randomised controlled study of four-layer compression versus Unna's Boot for venous ulcers. , 2004, Journal of wound care.