AUTORADIOGRAPHIC DEMONSTRATION OF INGESTED CHOLESTEROL-4-C-14 IN THE NORMAL AND ATHEROMATOUS AORTA.

Although it has been known for more than a century that atherosclerotic blood vessels contain large amounts of lipids and particularly cholesterol, there is still no agreement as to the mechanisms by which these substances accumulate either in the experimental animal or in human beings. Of the many theories of atherogenesis which have been proposed, one of the most attractive is the "infiltration" theory of Anitschkow,1 who suggested that lipid substances which are primarily responsible for atherosclerosis come into the vessel wall by infiltration from the vessel lumen. The present investigation was performed to obtain further evidence for or against this mechanism of atherogenesis in the rabbit. It is realized that the mechanisms of atherogenesis in the rabbit may be different from those in man.

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