Interrupter technique versus plethysmography for measurement of respiratory resistance in children with asthma or cystic fibrosis

The purpose of the present study was to compare measurements of respiratory system resistance by the interrupter method (Rrsint) with those of airway resistance by plethysmography (Raw) in nonobstructed children with asthma or cystic fibrosis (ratio of forced expiratory volume in 1 sec to vital capacity, FEV1/VC ≥80% with a forced expiratory flow rate between 25–75% of forced vital capacity, FEF25–75 ≥75% of normal values) and in obstructed children with the same diseases (FEV1/VC <80% and/or FEF25–75 <75% of normal values). Eighty‐one children (47 asthmatics and 34 suffering from cystic fibrosis) aged 5–18 years (mean 11.2 ± SD 3.4 years) were included in the study.

[1]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.

[2]  R. Peslin,et al.  Machinal properties of the upper airway wall in children and their influence on respiratory impedance measurements , 1992, Pediatric pulmonology.

[3]  P Baconnier,et al.  A theoretical analysis of interrupter technique for measuring respiratory mechanics. , 1988, Journal of applied physiology.

[4]  G. Liistro,et al.  Head position modifies upper airway resistance in men. , 1988, Journal of applied physiology.

[5]  D. Rodenstein,et al.  Demonstration of failure of body plethysmography in airway obstruction. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[6]  M. Silverman,et al.  Evaluation of a new interrupter device for measuring bronchial responsiveness and the response to bronchodilator in 3 year old children. , 1996, The European respiratory journal.

[7]  R Peslin,et al.  Thermal artifacts in plethysmographic airway resistance measurements. , 1995, Journal of applied physiology.

[8]  Giuseppe Liistro,et al.  Reassessment of the interruption technique for measuring flow resistance in humans. , 1989, Journal of applied physiology.

[9]  J. Speich,et al.  Measurements of respiratory system resistance by the interrupter technique in healthy and asthmatic children , 1997, Pediatric pulmonology.

[10]  H. Bisgaard,et al.  Lung function measurement in awake young children. , 1995, The European respiratory journal.

[11]  H. Bisgaard,et al.  Measurement of the specific airway resistance by plethysmography in young children accompanied by an adult. , 1997, The European respiratory journal.

[12]  Shephard Rj.  MECHANICAL CHARACTERISTICS OF THE HUMAN AIRWAY IN RELATION TO USE OF THE INTERRUPTER VALVE. , 1963 .

[13]  M. Silverman,et al.  A flow interruption device for measurement of airway resistance. , 1991, The European respiratory journal.

[14]  R. Kraemer,et al.  Dose-response relationships and time course of the response to systemic beta adrenoreceptor agonists in infants with bronchopulmonary disease. , 1988, Thorax.

[15]  M. Silverman,et al.  Accuracy and sensitivity of the interrupter technique for measuring the response to bronchial challenge in normal subjects. , 1993, The European respiratory journal.

[16]  R. Kraemer,et al.  Specific Approach on Dose-Response Curves to Inhaled Carbachol Assessed by the Interruption Technique in Children , 1993, Pediatric Research.

[17]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[18]  J. Bates,et al.  Measurement of alveolar pressure in closed-chest dogs during flow interruption. , 1989, Journal of applied physiology.

[19]  E. Carter,et al.  Evaluation of the interrupter technique for the use of assessing airway obstruction in children , 1994, Pediatric pulmonology.

[20]  M. Silverman,et al.  Evaluation of the interrupter technique for measuring change in airway resistance in 5‐year‐old asthmatic children , 1995, Pediatric pulmonology.

[21]  J. Bates,et al.  Respiratory mechanics in the normal dog determined by expiratory flow interruption. , 1989, Journal of applied physiology.