Does ‘altitude training’ increase exercise performance in elite athletes?

The general practice of altitude training is widely accepted as a means to enhance sport performance despite a lack of rigorous scientific studies. For example, the scientific gold-standard design of a double-blind, placebo-controlled, cross-over trial has never been conducted on altitude training. Given that few studies have utilised appropriate controls, there should be more scepticism concerning the effects of altitude training methodologies. In this brief review we aim to point out weaknesses in theories and methodologies of the various altitude training paradigms and to highlight the few well-designed studies to give athletes, coaches and sports medicine professionals the current scientific state of knowledge on common forms of altitude training. Another aim is to encourage investigators to design well-controlled studies that will enhance our understanding of the mechanisms and potential benefits of altitude training.

[1]  R. Jacobs,et al.  "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study. , 2012, Journal of applied physiology.

[2]  B. Levine,et al.  The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners. , 2008, Journal of applied physiology.

[3]  D B Pyne,et al.  Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure. , 2003, Journal of applied physiology.

[4]  M. Gassmann,et al.  Timing the arrival at 2340 m altitude for aerobic performance , 2007, Scandinavian journal of medicine & science in sports.

[5]  H. Hoppeler,et al.  Training in hypoxia and its effects on skeletal muscle tissue , 2008, Scandinavian journal of medicine & science in sports.

[6]  R. Jacobs,et al.  Four weeks of normobaric "live high-train low" do not alter muscular or systemic capacity for maintaining pH and K⁺ homeostasis during intense exercise. , 2012, Journal of applied physiology.

[7]  N. Secher,et al.  The role of haemoglobin mass on VO2max following normobaric ‘live high–train low’ in endurance-trained athletes , 2012, British Journal of Sports Medicine.

[8]  C. Lundby,et al.  Is live high–train low altitude training relevant for elite athletes with already high total hemoglobin mass? , 2012, Scandinavian journal of medicine & science in sports.

[9]  B. Saltin,et al.  Increased left ventricular muscle mass after long‐term altitude training in athletes , 1997 .

[10]  B. Saltin,et al.  Skeletal muscle adaptations to prolonged exposure to extreme altitude: a role of physical activity? , 2008, High altitude medicine & biology.

[11]  P. Bärtsch,et al.  Individual variation in the erythropoietic response to altitude training in elite junior swimmers , 2005, British Journal of Sports Medicine.

[12]  B D Levine,et al.  "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. , 1997, Journal of applied physiology.

[13]  D. B. Dill,et al.  Effects of equivalent sea-level and altitude training on VO2max and running performance. , 1975, Journal of applied physiology.

[14]  D. Jones,et al.  Carbohydrate sensing in the human mouth: effects on exercise performance and brain activity , 2009, The Journal of physiology.

[15]  B. Levine,et al.  Performance of runners and swimmers after four weeks of intermittent hypobaric hypoxic exposure plus sea level training. , 2007, Journal of applied physiology.

[16]  L. Romer,et al.  Implications of moderate altitude training for sea-level endurance in elite distance runners , 1998, European Journal of Applied Physiology and Occupational Physiology.

[17]  A. St. Clair Gibson,et al.  Effects of deception on exercise performance: implications for determinants of fatigue in humans. , 2012, Medicine and science in sports and exercise.

[18]  B. Levine,et al.  Effect of hypoxic "dose" on physiological responses and sea-level performance. , 2007, Medicine and science in sports and exercise.

[19]  R. Telford,et al.  VO2max and Haemoglobin Mass of Trained Athletes during High Intensity Training , 1997, International journal of sports medicine.

[20]  B. Levine,et al.  Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. , 2004, Journal of applied physiology.

[21]  B. Levine,et al.  Individual variation in response to altitude training. , 1998, Journal of applied physiology.

[22]  B. Saltin,et al.  Determinants of maximal oxygen uptake in severe acute hypoxia. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[23]  M. Gassmann,et al.  Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. , 2011, Journal of applied physiology.

[24]  R. Jacobs,et al.  Mitochondrial function in human skeletal muscle following high‐altitude exposure , 2013, Experimental physiology.

[25]  Bernard Marti,et al.  Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. , 2006, Journal of applied physiology.

[26]  C. Lundby,et al.  The response of human skeletal muscle tissue to hypoxia , 2009, Cellular and Molecular Life Sciences.

[27]  R Hugh Morton,et al.  Deception by manipulating the clock calibration influences cycle ergometer endurance time in males. , 2009, Journal of science and medicine in sport.

[28]  Benjamin D Levine,et al.  Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume. , 2005, Journal of applied physiology.

[29]  B. Saltin,et al.  Skeletal Muscle Myofibrillar and Sarcoplasmic Protein Synthesis Rates Are Affected Differently by Altitude-Induced Hypoxia in Native Lowlanders , 2010, PloS one.

[30]  Julien V Brugniaux,et al.  Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners. , 2006, Journal of applied physiology.

[31]  B. Saltin,et al.  Exercise economy does not change after acclimatization to moderate to very high altitude , 2006, Scandinavian journal of medicine & science in sports.

[32]  W. Hopkins,et al.  Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume. , 2005, Journal of applied physiology.

[33]  K. Eckardt,et al.  Effects of iron supplementation on total body hemoglobin during endurance training at moderate altitude. , 1999, International journal of sports medicine.

[34]  Carsten Lundby,et al.  Blood doping and its detection. , 2011, Blood.

[35]  B. Levine,et al.  “Living high − training low” altitude training improves sea level performance in male and female élite runners , 2001, Journal of applied physiology.

[36]  C. Dehnert,et al.  Unchanged anaerobic and aerobic performance after short-term intermittent hypoxia. , 2007, Medicine and science in sports and exercise.

[37]  J. Richalet,et al.  Live and/or sleep high:train low, using normobaric hypoxia , 2008, Scandinavian journal of medicine & science in sports.

[38]  Eileen Y. Robertson,et al.  Reproducibility of performance changes to simulated live high/train low altitude. , 2010, Medicine and science in sports and exercise.

[39]  H. Toussaint,et al.  Effect of high-intensity hypoxic training on sea-level swimming performances. , 2002, Journal of applied physiology.

[40]  C. Lundby,et al.  Peak heart rate decreases with increasing severity of acute hypoxia. , 2001, High altitude medicine & biology.

[41]  Will G Hopkins,et al.  Sea-Level Exercise Performance Following Adaptation to Hypoxia , 2009, Sports medicine.

[42]  J. Fulford,et al.  Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia , 2011, The Journal of physiology.

[43]  C J Gore,et al.  Altitude training at 2690m does not increase total haemoglobin mass or sea level VO2max in world champion track cyclists. , 1998, Journal of science and medicine in sport.

[44]  Konrad E Bloch,et al.  Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing. , 2012, Sleep.

[45]  C J Gore,et al.  Live high:train low increases muscle buffer capacity and submaximal cycling efficiency. , 2001, Acta physiologica Scandinavica.