Impact of T wave amplitude in lead aVR on predicting cardiac events in ischemic and nonischemic cardiomyopathy patients with an implantable cardioverter defibrillator

T wave amplitudes during ventricular repolarization in the lead aVR (TAaVR) are shown to be associated with adverse cardiac events in patients with several cardiovascular diseases, such as postmyocardial infarction. However, the utility of TAaVR has not been previously evaluated in patients with cardiomyopathy who have received implantable cardioverter defibrillators (ICD). Patients with ischemic or nonischemic cardiomyopathy (ICM or NICM, respectively) and who received an ICD may experience worsening of their condition due to the introduction of electric shock during treatment. This study aimed to investigate the utility of TAaVR in the prediction of cardiac events in ICM or NICM patients with ICD.

[1]  K. Hayashi,et al.  T wave amplitude in lead aVR as a novel diagnostic marker for cardiac sarcoidosis , 2017, Heart and Vessels.

[2]  John L Sapp,et al.  Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs. , 2016, The New England journal of medicine.

[3]  K. Hayashi,et al.  Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. , 2015, Journal of cardiology.

[4]  M. Gold,et al.  Full-Body MRI in Patients With an Implantable Cardioverter-Defibrillator: Primary Results of a Randomized Study. , 2015, Journal of the American College of Cardiology.

[5]  T. Schlegel,et al.  The prognostic value of positive T-wave in lead aVR in hemodialysis patients , 2015, Clinical and Experimental Nephrology.

[6]  John Sapp,et al.  EHRA/HRS/APHRS expert consensus on ventricular arrhythmias , 2014, Heart rhythm.

[7]  I. Savelieva,et al.  EHRA/HRS/APHRS expert consensus on ventricular arrhythmias. , 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[8]  K. Hayashi,et al.  High Sensitivity of Late Gadolinium Enhancement for Predicting Microscopic Myocardial Scarring in Biopsied Specimens in Hypertrophic Cardiomyopathy , 2014, PloS one.

[9]  A. Kadish,et al.  Sudden cardiac death risk stratification in patients with nonischemic dilated cardiomyopathy. , 2014, Journal of the American College of Cardiology.

[10]  J. Morgan,et al.  Late gadolinium enhancement cardiac magnetic resonance imaging for the prediction of ventricular tachyarrhythmic events: a meta‐analysis , 2013, European journal of heart failure.

[11]  M. Shoda,et al.  Guidelines for Non-Pharmacotherapy of Cardiac Arrhythmias (JCS 2011). , 2012, Circulation journal : official journal of the Japanese Circulation Society.

[12]  J. Kadota,et al.  Upright T waves in lead aVR are associated with cardiac death or hospitalization for heart failure in patients with a prior myocardial infarction , 2012, Heart and Vessels.

[13]  E. Watanabe,et al.  Prognostic Significance of T‐Wave Amplitude in Lead aVR in Heart Failure Patients with Narrow QRS Complexes , 2011, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[14]  A. Baranchuk,et al.  Clinical Value of Lead aVR , 2011, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[15]  J. Kadota,et al.  Associations of positive T wave in lead aVR with hemodynamic, coronary, and left ventricular angiographic findings in anterior wall old myocardial infarction. , 2011, Journal of cardiology.

[16]  Mikhail V. Arkhipov,et al.  Clinical Utility of aVR—The Neglected Electrocardiographic Lead , 2010, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[17]  D. Mark,et al.  Prognostic importance of defibrillator shocks in patients with heart failure. , 2008, The New England journal of medicine.

[18]  Changyu Shen,et al.  Fragmented Wide QRS on a 12-Lead ECG: A Sign of Myocardial Scar and Poor Prognosis , 2008, Circulation. Arrhythmia and electrophysiology.

[19]  V. Froelicher,et al.  The Prognostic Value of T Wave Amplitude in Lead aVR in Males , 2008, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[20]  A. Budaj,et al.  Relationship of ST elevation in lead aVR with angiographic findings and outcome in non-ST elevation acute coronary syndromes. , 2007, American heart journal.

[21]  K. Hayashi,et al.  Differences in the diagnostic value of various criteria of negative T waves for hypertrophic cardiomyopathy based on a molecular genetic diagnosis. , 2007, Clinical science.

[22]  M. Das,et al.  Significance of a Fragmented QRS Complex Versus a Q Wave in Patients With Coronary Artery Disease , 2006, Circulation.

[23]  A. Hasslocher-Moreno,et al.  T-wave axis deviation as an independent predictor of mortality in chronic Chagas' disease. , 2004, The American journal of cardiology.

[24]  Masami Shimizu,et al.  Diagnostic value of abnormal Q waves for identification of preclinical carriers of hypertrophic cardiomyopathy based on a molecular genetic diagnosis. , 2004, European heart journal.

[25]  M. Sokolow,et al.  The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. , 1949, American heart journal.

[26]  P. Kirchhof,et al.  EHRA / HRS / APHRS expert consensus on ventricular arrhythmias , 2014 .

[27]  V. Verma,et al.  Can An Upright T-Wave in Lead aVR be a Clinical Marker for Underlying Myocardial Disease , 2003 .

[28]  W. Youden,et al.  Index for rating diagnostic tests , 1950, Cancer.