Clinical Value of Flow Cytometric DNA analysis in colorectal cancers

The distribution of DNA in colon cancers and its relationship to factors related to clinical features of cancer invasion and noncurative operation are evaluated by using paraffin-embedded specimens. The survival in patients with DNA diploid tumor is apparently much more satis- factory than that in patients with aneuploid tumor in stage B and C patients in accor- dance with advances in the disease stage. The deeper the depth of cancer invasion reaches, the more the number of DNA aneuploid tumor increased in the distribution. Non-curative operation was more frequently made in patients with DNA aneup- loid tumor rather than in patients with DNA diploid one. In conclusion, analysis of the distribution of DNA contributes to assessment of the prognosis of colorectal carcinoma in combination with conventional prog- nostic parameter of clinicopathologic variables.