Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

[1]  Sorana D. Bolboacă,et al.  Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus , 2019, International journal of nanomedicine.

[2]  D. Gerlag,et al.  Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry , 2019, Front. Immunol..

[3]  J. Couper,et al.  Early-life factors contributing to type 1 diabetes , 2019, Diabetologia.

[4]  Peter S. Linsley,et al.  Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes. , 2018, JCI insight.

[5]  K. Dahl-Jørgensen,et al.  Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease , 2018, Diabetologia.

[6]  E. Bonifacio,et al.  Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors , 2018, Science Immunology.

[7]  P. Marchetti,et al.  Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource , 2018, Diabetologia.

[8]  P. Marchetti,et al.  IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells , 2018, Diabetologia.

[9]  N. Morgan,et al.  Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes , 2017, Diabetic medicine : a journal of the British Diabetic Association.

[10]  B. Edwin,et al.  Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes. , 2017, The American journal of pathology.

[11]  C. Chamberlain,et al.  Human pancreatic neuro-insular network in health and fatty infiltration , 2017, Diabetologia.

[12]  P. Pasricha,et al.  Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology , 2017, Diabetologia.

[13]  B. Giepmans,et al.  Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary? , 2017, Diabetologia.

[14]  P. Marchetti,et al.  Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes , 2017, Diabetologia.

[15]  N. Morgan,et al.  Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes , 2016, Front. Physiol..

[16]  D. Harlan,et al.  Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes , 2016, Nature Medicine.

[17]  O. Korsgren,et al.  Insulitis in human diabetes: a histological evaluation of donor pancreases , 2016, Diabetologia.

[18]  N. Morgan,et al.  Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes , 2016, Diabetologia.

[19]  K. Dahl-Jørgensen,et al.  Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes , 2016, Diabetes.

[20]  N. Morgan,et al.  Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes , 2016, Diabetes.

[21]  M. Atkinson,et al.  Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes , 2015, Diabetes.

[22]  M. Battaglia,et al.  Abnormalities of the Exocrine Pancreas in Type 1 Diabetes , 2015, Current Diabetes Reports.

[23]  U. Boggi,et al.  Mast cells infiltrate pancreatic islets in human type 1 diabetes , 2015, Diabetologia.

[24]  D. Accili,et al.  The new biology of diabetes , 2015, Diabetologia.

[25]  M. Campbell-Thompson.  Organ donor specimens: What can they tell us about type 1 diabetes? , 2015, Pediatric diabetes.

[26]  M. V. von Herrath,et al.  Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase , 2015, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[27]  M. Grabherr,et al.  Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro , 2015, Diabetes.

[28]  J. Shuster,et al.  The influence of type 1 diabetes on pancreatic weight , 2015, Diabetologia.

[29]  N. Morgan,et al.  Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes , 2014, Diabetes.

[30]  S. Richardson,et al.  Islet inflammation in human type 1 diabetes mellitus , 2014, IUBMB life.

[31]  C. Parish,et al.  Extracellular Matrix Components in the Pathogenesis of Type 1 Diabetes , 2014, Current Diabetes Reports.

[32]  P. Bingley,et al.  Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes , 2014, Diabetes.

[33]  M. Atkinson,et al.  New Insight on Human Type 1 Diabetes Biology: nPOD and nPOD-Transplantation , 2014, Current Diabetes Reports.

[34]  F. Levine,et al.  Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes , 2014, Cell Death and Disease.

[35]  N. Morgan,et al.  Pancreatic Pathology in Type 1 Diabetes Mellitus , 2014, Endocrine Pathology.

[36]  B. Giepmans,et al.  The diagnosis of insulitis in human type 1 diabetes , 2013, Diabetologia.

[37]  V. Periwal,et al.  Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes , 2013, PloS one.

[38]  Liangyi Chen,et al.  Imaging beta-cell mass and function in situ and in vivo , 2013, Journal of Molecular Medicine.

[39]  R. Kappelhoff,et al.  The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human , 2013, Diabetes.

[40]  M. Atkinson,et al.  Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes , 2012, Diabetes/metabolism research and reviews.

[41]  S. M. Tracy,et al.  Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma , 2012, Clinical and experimental immunology.

[42]  V. Periwal,et al.  Quantification of islet size and architecture , 2012, Islets.

[43]  J. Walters,et al.  Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes , 2012, Diabetes.

[44]  M. Atkinson,et al.  Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients , 2012, The Journal of experimental medicine.

[45]  P. in’t Veld.  Insulitis in human type 1 diabetes , 2011 .

[46]  T. Berney,et al.  Unique Arrangement of α- and β-Cells in Human Islets of Langerhans , 2010, Diabetes.

[47]  P. Haentjens,et al.  β-Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support , 2010, Diabetes.

[48]  U. Boggi,et al.  Islet inflammation and CXCL10 in recent‐onset type 1 diabetes , 2010, Clinical and experimental immunology.

[49]  S. Bonner-Weir,et al.  Dimorphic histopathology of long-standing childhood-onset diabetes , 2010, Diabetologia.

[50]  S. Richardson,et al.  Analysis of islet inflammation in human type 1 diabetes , 2009, Clinical and experimental immunology.

[51]  R. Rizza,et al.  Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis , 2007, Diabetologia.

[52]  D. Pipeleers,et al.  Screening for Insulitis in Adult Autoantibody-Positive Organ Donors , 2007, Diabetes.

[53]  U. Boggi,et al.  Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients , 2007, Proceedings of the National Academy of Sciences.

[54]  Mark S. Anderson,et al.  The NOD mouse: a model of immune dysregulation. , 2005, Annual review of immunology.

[55]  R. Hardman,et al.  Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus , 1987, Diabetologia.

[56]  C. Liddle,et al.  The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom , 1986, Diabetologia.

[57]  A. Foulis,et al.  The pancreas in recent-onset Type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue , 1984, Diabetologia.

[58]  T. Mandrup-Poulsen,et al.  Apoptotic signal transduction pathways in diabetes. , 2003, Biochemical pharmacology.

[59]  E. Gale,et al.  The discovery of type 1 diabetes. , 2001, Diabetes.

[60]  E. Leiter.  The NOD Mouse: A Model for Insulin‐Dependent Diabetes Mellitus , 1997, Current protocols in immunology.

[61]  K. Yamagata,et al.  Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. , 1993, The Journal of clinical investigation.

[62]  A. Meager,et al.  IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS , 1987, The Lancet.

[63]  D. Gray,et al.  Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. , 1986, Clinical and experimental immunology.

[64]  L. Orci,et al.  New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat , 1982, Diabetes.

[65]  T. Seemayer,et al.  Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex , 1981, The Journal of experimental medicine.

[66]  Y. Tochino,et al.  Breeding of a non-obese, diabetic strain of mice. , 1980, Jikken dobutsu. Experimental animals.

[67]  W. Gepts.  Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus , 1965, Diabetes.