Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

[1]  Won Jin Lee,et al.  Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis. , 2013, Gene.

[2]  P. Prabhakar.  Therapeutic Strategies , 2013, The Journal of Headache and Pain.

[3]  Y. Tone,et al.  Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. , 2012, The international journal of neuropsychopharmacology.

[4]  A. Roebroek,et al.  LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier , 2011, Neurobiology of Aging.

[5]  Bernhard Hennig,et al.  Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases. , 2011, Antioxidants & redox signaling.

[6]  M. Beal,et al.  Neuroprotective strategies involving ROS in Alzheimer disease. , 2011, Free radical biology & medicine.

[7]  J. Noa,et al.  Aging. Alzheimer's disease. , 2011, Harvard women's health watch.

[8]  Arturo Pujia,et al.  Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis , 2011, Journal of cellular and molecular medicine.

[9]  H. D. de Vries,et al.  Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy. , 2011, Antioxidants & redox signaling.

[10]  P. Kovacic,et al.  Cell signaling and receptors with resorcinols and flavonoids: redox, reactive oxygen species, and physiological effects , 2011, Journal of receptor and signal transduction research.

[11]  N. Arispe,et al.  Fluorescent Analysis of the Cell-Selective Alzheimer's Disease Aβ Peptide Surface Membrane Binding: Influence of Membrane Components , 2011, International journal of Alzheimer's disease.

[12]  Yong Gu,et al.  Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. , 2011, Frontiers in bioscience.

[13]  Jeffrey F. Thompson,et al.  Matrix Metalloproteinases Are Associated With Increased Blood–Brain Barrier Opening in Vascular Cognitive Impairment , 2011, Stroke.

[14]  V. Srikanth,et al.  Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease , 2011, Neurobiology of Aging.

[15]  D. Rowlands,et al.  Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells: Roles for F-Actin and GPR30 , 2011, Hypertension.

[16]  J. Luchsinger,et al.  Dietary Inflammation Factor Rating System and Risk of Alzheimer Disease in Elders , 2011, Alzheimer disease and associated disorders.

[17]  M. Mullan,et al.  Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer's disease. , 2011, Cytokine.

[18]  V. Marchesi,et al.  Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative‐induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  S. Leurgans,et al.  Sources of variability in estimates of the prevalence of Alzheimer’s disease in the United States , 2011, Alzheimer's & Dementia.

[20]  D. Tang,et al.  Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE) , 2011 .

[21]  S. Faraone,et al.  Review Article: Genetics of Alzheimer Disease , 2010, Journal of geriatric psychiatry and neurology.

[22]  J. Lafuente,et al.  Oxidative stress in Alzheimer's disease hippocampus: A topographical study , 2010, Journal of the Neurological Sciences.

[23]  D. Butterfield,et al.  Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. , 2010, Free radical biology & medicine.

[24]  R. Deane,et al.  Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain , 2010, Journal of neurochemistry.

[25]  R. McCarron,et al.  Increase in blood–brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast‐induced traumatic brain injury , 2010, Journal of neuroscience research.

[26]  Bengt R. Johansson,et al.  Pericytes regulate the blood–brain barrier , 2010, Nature.

[27]  T. Schulz,et al.  Activation of mitochondrial energy metabolism protects against cardiac failure , 2010, Aging.

[28]  K. Blennow,et al.  Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment , 2010, Neurobiology of Aging.

[29]  S. Nam,et al.  Inflammation and Alzheimer’s disease , 2010, Archives of pharmacal research.

[30]  D. Paris,et al.  Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier , 2010, Cytotechnology.

[31]  Yuhai Zhao,et al.  Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease* , 2010, The Journal of Biological Chemistry.

[32]  J. Jia,et al.  The interleukin-6 gene −572C/G promoter polymorphism modifies Alzheimer's risk in APOE ɛ4 carriers , 2010, Neuroscience Letters.

[33]  Marco Racchi,et al.  beta-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain. , 2010, Pharmacological research.

[34]  G. Perry,et al.  Oxidative stress in Alzheimer disease: A possibility for prevention , 2010, Neuropharmacology.

[35]  M. Valko,et al.  Metals, oxidative stress and neurodegenerative disorders , 2010, Molecular and Cellular Biochemistry.

[36]  G. Münch,et al.  Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles? , 2010, Mutation research.

[37]  D. Butterfield,et al.  Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics , 2010, Neurobiology of Disease.

[38]  H. Yi,et al.  PPARγ inhibits inflammatory reaction in oxidative stress induced human diploid fibloblast , 2010, Cell biochemistry and function.

[39]  P. Agostinho,et al.  Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. , 2010, Current pharmaceutical design.

[40]  K. Selvakumar,et al.  Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3) , 2010, Molecular and Cellular Biochemistry.

[41]  M. O’Banion,et al.  Neuroinflammatory processes in Alzheimer’s disease , 2010, Journal of Neural Transmission.

[42]  T. Révész,et al.  CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE. , 2010, Hirosaki igaku = Hirosaki medical journal.

[43]  M. Chatzopoulou,et al.  RAGE: a multi-ligand receptor unveiling novel insights in health and disease. , 2010, Current medicinal chemistry.

[44]  Claudia Schilling,et al.  Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease , 2010, International Psychogeriatrics.

[45]  C. Caruso,et al.  Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications. , 2010, Rejuvenation research.

[46]  D. Willbold,et al.  Transport of Alzheimer disease amyloid-beta-binding D-amino acid peptides across an in vitro blood-brain barrier model. , 2010, Rejuvenation research.

[47]  R. Quirion,et al.  Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease. , 2010, The American journal of pathology.

[48]  A. Maggi,et al.  Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency. , 2010, Atherosclerosis.

[49]  G. Rimbach,et al.  Mechanisms Involved in the Modulation of Astroglial Resistance to Oxidative Stress Induced by Activated Microglia: Antioxidative Systems, Peroxide Elimination, Radical Generation, Lipid Peroxidation , 2010, Neurotoxicity Research.

[50]  L. Lue,et al.  RAGE‐dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[51]  C. Brayne,et al.  Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain , 2010, Neurobiology of Aging.

[52]  M. Zhang,et al.  Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress , 2010, Neuroscience.

[53]  D. Butterfield,et al.  Age-related loss of phospholipid asymmetry in APP NLh /APP NLh x PS-1 P264L /PS-1 P264L human double mutant knock-in mice: Relevance to Alzheimer disease , 2010, Neurobiology of Disease.

[54]  Thomas P Davis,et al.  Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[55]  R. Trullas,et al.  Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. , 2010, Cell calcium.

[56]  Liao Mc,et al.  Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro. , 2010 .

[57]  T. Montine,et al.  Biomarkers of oxidative damage and inflammation in Alzheimer's disease. , 2010, Biomarkers in medicine.

[58]  S. Scheff,et al.  Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex , 2010, Journal of neuropathology and experimental neurology.

[59]  C. Brayne,et al.  Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer‐type pathology in the ageing brain , 2010, Neuropathology and applied neurobiology.

[60]  R. Veerhuis,et al.  Biomarkers of inflammation and amyloid-β phagocytosis in patients at risk of Alzheimer disease , 2010, Experimental Gerontology.

[61]  O. Ambrée,et al.  Reduction of Cerebral Oxidative Stress Following Environmental Enrichment in Mice with Alzheimer‐Like Pathology , 2010, Brain pathology.

[62]  C. Humpel,et al.  Matrix metalloproteinases-2 and -3 are reduced in cerebrospinal fluid with low beta-amyloid1–42 levels , 2009, Neuroscience Letters.

[63]  P. Couraud,et al.  Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[64]  C. Allen,et al.  Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke , 2009, International journal of stroke : official journal of the International Stroke Society.

[65]  E. Aronica,et al.  Specific Human Astrocyte Subtype Revealed by Affinity Purified GFAP+1 Antibody; Unpurified Serum Cross-Reacts with Neurofilament-L in Alzheimer , 2009, PloS one.

[66]  D. Butterfield,et al.  Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment , 2009, Journal of bioenergetics and biomembranes.

[67]  E. Niki.  Lipid peroxidation: physiological levels and dual biological effects. , 2009, Free radical biology & medicine.

[68]  Mario Cortina-Borja,et al.  Open Access Journal of Neuroinflammation Replication by the Epistasis Project of the Interaction between the Genes for Il-6 and Il-10 in the Risk of Alzheimer's Disease , 2022 .

[69]  N. Bogdanovic,et al.  Blood-brain barrier alterations in ageing and dementia , 2009, Journal of the Neurological Sciences.

[70]  Y. Xia,et al.  Upregulation of RAGE at the blood‐brain barrier in streptozotocin‐induced diabetic mice , 2009, Synapse.

[71]  G. Halliday,et al.  Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease , 2009, Brain pathology.

[72]  B. Culver,et al.  Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice , 2009, Neuroscience.

[73]  S. Pimplikar,et al.  Reassessing the amyloid cascade hypothesis of Alzheimer's disease. , 2009, The international journal of biochemistry & cell biology.

[74]  C. Wellington,et al.  Why lipids are important for Alzheimer disease? , 2009, Molecular and Cellular Biochemistry.

[75]  P. Tang,et al.  Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease. , 2009, Free radical biology & medicine.

[76]  C. Allen,et al.  Antioxidants attenuate hyperglycaemia‐mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability , 2009, Diabetes, obesity & metabolism.

[77]  Y. Xia,et al.  Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice , 2009, Neuropharmacology.

[78]  W. Banks,et al.  Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease , 2009, Brain, Behavior, and Immunity.

[79]  Marie-Claude Potier,et al.  Classification and basic pathology of Alzheimer disease , 2009, Acta Neuropathologica.

[80]  S. Estus,et al.  LRP1 shedding in human brain: roles of ADAM10 and ADAM17 , 2009, Molecular Neurodegeneration.

[81]  V. O’Donnell,et al.  Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids. , 2009, Free radical biology & medicine.

[82]  F. LaFerla,et al.  Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology , 2009, Neurobiology of Disease.

[83]  Berislav V. Zlokovic,et al.  Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease , 2009, Acta Neuropathologica.

[84]  R. Deane,et al.  Clearance of amyloid-β peptide across the blood-brain barrier: Implication for therapies in Alzheimer’s disease , 2009 .

[85]  M. Gearing,et al.  Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease. , 2009, Free radical biology & medicine.

[86]  R. Kuljiš,et al.  The Role of Neuroimmunomodulation in Alzheimer's Disease , 2009, Annals of the New York Academy of Sciences.

[87]  P. Gil,et al.  Metalloproteinase’s Activity and Oxidative Stress in Mild Cognitive Impairment and Alzheimer’s Disease , 2009, Neurochemical Research.

[88]  M. Chaturvedi,et al.  ORIGINAL ARTICLE: Lipopolysaccharide Alters the Vaginal Electrical Resistance in Cycling and Pregnant Mice , 2009, American journal of reproductive immunology.

[89]  J. Im,et al.  Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress , 2009, Journal of Neurochemistry.

[90]  S. Moochhala,et al.  Involvement of ROS in BBB dysfunction , 2009, Free radical research.

[91]  B. Tang.  Neuronal protein trafficking associated with Alzheimer disease , 2009, Cell adhesion & migration.

[92]  N. Durany,et al.  Oxidative stress in Alzheimer disease , 2009, Cell adhesion & migration.

[93]  E. Kojro,et al.  Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases* , 2008, Journal of Biological Chemistry.

[94]  V. Laporte,et al.  Novel role of CXCR2 in regulation of gamma-secretase activity. , 2008, ACS chemical biology.

[95]  A. Thomson,et al.  Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. , 2008, Biochemical Society transactions.

[96]  Katie Hamm,et al.  apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. , 2008, The Journal of clinical investigation.

[97]  Y. Stern,et al.  Survival in Alzheimer disease , 2008, Neurology.

[98]  R. Vassar,et al.  The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology* , 2008, Journal of Biological Chemistry.

[99]  P. Agostinho,et al.  Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades , 2008, Neuroscience.

[100]  K. Herrup,et al.  Aβ Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease , 2008, The Journal of Neuroscience.

[101]  F. Yan,et al.  Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia , 2008, Acta Neuropathologica.

[102]  A. Richardson,et al.  Lipid peroxidation up‐regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer’s disease , 2008, Journal of neurochemistry.

[103]  J. Provias,et al.  Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis. , 2008, Current Alzheimer research.

[104]  Ilya Bezprozvanny,et al.  Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease , 2008, Trends in Neurosciences.

[105]  C. Masters,et al.  Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ , 2008, Neuron.

[106]  M. Memo,et al.  Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease. , 2008, Free radical biology & medicine.

[107]  Á. Simonyi,et al.  Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons , 2008, Journal of neurochemistry.

[108]  C. Albright,et al.  Therapeutic Strategies for Alzheimer’s Disease , 2008, Molecular Neurobiology.

[109]  C. Venugopal,et al.  Beta-secretase: structure, function, and evolution. , 2008, CNS & neurological disorders drug targets.

[110]  R. Deane,et al.  The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. , 2008, Current pharmaceutical design.

[111]  Maurizio Memo,et al.  Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease , 2008, Journal of cellular and molecular medicine.

[112]  M. Dalakas,et al.  Interrelation of inflammation and APP in sIBM: IL-1β induces accumulation of β-amyloid in skeletal muscle , 2008, Brain : a journal of neurology.

[113]  D. Butterfield,et al.  Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease , 2008, Neurobiology of Disease.

[114]  C. Johanson,et al.  Apolipoprotein E, Amyloid-&bgr;, and Blood-Brain Barrier Permeability in Alzheimer Disease , 2008, Journal of neuropathology and experimental neurology.

[115]  N. Grigoriadis,et al.  Increased expression of the γ‐secretase components presenilin‐1 and nicastrin in activated astrocytes and microglia following traumatic brain injury , 2008, Glia.

[116]  N. Belyaev,et al.  Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease. , 2008, Current Alzheimer research.

[117]  E. Hol,et al.  Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses , 2008, Proteomics.

[118]  M. Memo,et al.  Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease , 2008, Neurobiology of Disease.

[119]  R. Pacchiana,et al.  Emerging concepts of how β-amyloid proteins and pro-inflammatory cytokines might collaborate to produce an 'Alzheimer brain' (Review). , 2008, Molecular medicine reports.

[120]  James B. Mitchell,et al.  Brain Redox Imaging Using Blood—Brain Barrier-Permeable Nitroxide MRI Contrast Agent , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[121]  Peter J. Crouch,et al.  The role of metals in modulating metalloprotease activity in the AD brain , 2008, European Biophysics Journal.

[122]  M. Barcikowska,et al.  Plasma beta amyloid and cytokine profile in women with Alzheimer's disease. , 2008, Neuro endocrinology letters.

[123]  G. Perry,et al.  Alzheimer disease and the role of free radicals in the pathogenesis of the disease. , 2008, CNS & neurological disorders drug targets.

[124]  M. De la Fuente,et al.  Plasma Aminothiol Compounds, but Not Serum Tumor Necrosis Factor Receptor II and Soluble Receptor for Advanced Glycation End Products, Are Related to the Cognitive Impairment in Alzheimer’s Disease and Mild Cognitive Impairment Patients , 2007, Neuroimmunomodulation.

[125]  X. Chen,et al.  RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. , 2007, Current molecular medicine.

[126]  M. Mattson,et al.  Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein , 2007 .

[127]  G. Gibson,et al.  Oxidative Stress and Transcriptional Regulation in Alzheimer Disease , 2007, Alzheimer disease and associated disorders.

[128]  C. Caltagirone,et al.  Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. , 2007, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[129]  Manuel Buttini,et al.  Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice* , 2007, Journal of Biological Chemistry.

[130]  D. Butterfield,et al.  Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment , 2007 .

[131]  R. Maier,et al.  Oxidative stress, lipid rafts, and macrophage reprogramming. , 2007, Antioxidants & redox signaling.

[132]  Amy Chan,et al.  Folate deprivation increases presenilin expression, gamma‐secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S‐adenosyl methionine , 2007, Journal of neurochemistry.

[133]  Sébastien Tilleux,et al.  Neuroinflammation and regulation of glial glutamate uptake in neurological disorders , 2007, Journal of neuroscience research.

[134]  Roberto Cappai,et al.  The redox chemistry of the Alzheimer's disease amyloid β peptide , 2007 .

[135]  D. Bernhard,et al.  Smoking, oxidative stress and cardiovascular diseases--do anti-oxidative therapies fail? , 2007, Current medicinal chemistry.

[136]  E. Brandan,et al.  A Novel Modulatory Mechanism of Transforming Growth Factor-β Signaling through Decorin and LRP-1* , 2007, Journal of Biological Chemistry.

[137]  S. Vannucci,et al.  Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[138]  S. Elmore.  Apoptosis: A Review of Programmed Cell Death , 2007, Toxicologic pathology.

[139]  J. Franco,et al.  Connecting TNF-α Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid β Protein , 2007, The Journal of Neuroscience.

[140]  J. Perez-polo,et al.  Differential regulation of BACE1 promoter activity by nuclear factor‐κB in neurons and glia upon exposure to β‐amyloid peptides , 2007 .

[141]  W. Klein,et al.  Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine* , 2007, Journal of Biological Chemistry.

[142]  James Haorah,et al.  Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood–brain barrier dysfunction , 2007, Journal of neurochemistry.

[143]  P. Grammas,et al.  MIP1‐α expression is elevated in Alzheimer's vessels and is regulated by oxidative and lipid stress , 2007 .

[144]  M. Lardelli,et al.  Alzheimer disease: amyloidogenesis, the presenilins and animal models. , 2007, Biochimica et biophysica acta.

[145]  Michael T. Heneka,et al.  Inflammatory processes in Alzheimer's disease , 2007, Journal of Neuroimmunology.

[146]  D. Butterfield,et al.  Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI)—2′,3′-dideoxycytidine (ddC): Relevance to HIV-dementia , 2007, Experimental Neurology.

[147]  C. Caltagirone,et al.  Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer’s disease , 2007, Journal of Neurology, Neurosurgery & Psychiatry.

[148]  D. Bonifati,et al.  Role of complement in neurodegeneration and neuroinflammation. , 2007, Molecular immunology.

[149]  K. Hasan,et al.  Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease , 2006, Clinical Neuroscience Research.

[150]  B. T. Hawkins,et al.  Increased blood–brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases , 2006, Diabetologia.

[151]  D. Butterfield,et al.  In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders. , 2006, Free radical biology & medicine.

[152]  J. Koziol,et al.  Vascular matrix adhesion and the blood-brain barrier. , 2006, Biochemical Society transactions.

[153]  C. Kawas,et al.  Alzheimer's and dementia in the oldest-old: a century of challenges. , 2006, Current Alzheimer research.

[154]  D. Butterfield,et al.  Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice. , 2006, Free radical biology & medicine.

[155]  Lilia Alberghina,et al.  The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration , 2006, BMC Neuroscience.

[156]  S. Ballinger,et al.  Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. , 2006, Circulation research.

[157]  V. Gogvadze,et al.  Mitochondrial regulation of apoptotic cell death. , 2006, Chemico-biological interactions.

[158]  K. Hensley,et al.  On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. , 2006, Antioxidants & redox signaling.

[159]  G. Multhaup.  Amyloid Precursor Protein and BACE Function as Oligomers , 2006, Neurodegenerative Diseases.

[160]  M. Schrag,et al.  Deposition of iron and β‐amyloid plaques is associated with cortical cellular damage in rabbits fed with long‐term cholesterol‐enriched diets , 2006, Journal of neurochemistry.

[161]  R. Flore,et al.  Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[162]  Tony Wyss-Coray,et al.  Inflammation in Alzheimer disease: driving force, bystander or beneficial response? , 2006, Nature Medicine.

[163]  G. D. del Zoppo,et al.  Integrin-matrix interactions in the cerebral microvasculature. , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[164]  D. Butterfield,et al.  Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Aβ(1–42): Implications for Alzheimer's disease , 2006, Neurobiology of Aging.

[165]  Shaharyar M. Khan,et al.  Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease. , 2006, Current Alzheimer research.

[166]  R. de Silva,et al.  Oxidative stress: apoptosis in neuronal injury. , 2006, Current Alzheimer research.

[167]  J. Haines,et al.  Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases , 2006, Neurobiology of Aging.

[168]  Miles C. Miller,et al.  RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease , 2006, Acta Neuropathologica.

[169]  T. Bayer,et al.  A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease. , 2006, Clinical neuropathology.

[170]  S. Goswami,et al.  An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. , 2006, Antioxidants & redox signaling.

[171]  C. Masters,et al.  Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity* , 2006, Journal of Biological Chemistry.

[172]  Katsuaki Sato,et al.  Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response. , 2006, Blood.

[173]  K. Bhalla,et al.  Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family. , 2006, Cancer Research.

[174]  D. Butterfield,et al.  Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach , 2006, Neurobiology of Disease.

[175]  J. Standridge.  Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease. , 2006, Current Alzheimer research.

[176]  W. Griffin,et al.  Inflammation and neurodegenerative diseases. , 2006, The American journal of clinical nutrition.

[177]  J. Cidlowski,et al.  Selective Role of Intracellular Chloride in the Regulation of the Intrinsic but Not Extrinsic Pathway of Apoptosis in Jurkat T-cells* , 2006, Journal of Biological Chemistry.

[178]  R. Mahley,et al.  Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[179]  V. Papadopoulos,et al.  Beta-Amyloid and Oxidative Stress Jointly Induce Neuronal Death, Amyloid Deposits, Gliosis, and Memory Impairment in the Rat Brain , 2005, Pharmacology.

[180]  A. Fagan,et al.  P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. , 2005, The Journal of clinical investigation.

[181]  V. Mathura,et al.  Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease. , 2005, Brain research. Molecular brain research.

[182]  L. Provinciali,et al.  Peroxynitrite production and NOS expression in astrocytes U373MG incubated with lipoproteins from Alzheimer patients , 2005, Brain Research.

[183]  B. Winblad,et al.  Levels of mTOR and its downstream targets 4E‐BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain , 2005, The FEBS journal.

[184]  H. Arai,et al.  Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease , 2005, Neurobiology of Aging.

[185]  R. Martins,et al.  TNF polymorphisms in Alzheimer disease and functional implications on CSF beta‐amyloid levels , 2005, Human mutation.

[186]  G. Rosenberg,et al.  Matrix metalloproteinases and free radicals in cerebral ischemia. , 2005, Free radical biology & medicine.

[187]  L. Lue,et al.  Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease. , 2005, Current drug targets. CNS and neurological disorders.

[188]  D. Butterfield,et al.  In vivo protection of synaptosomes from oxidative stress mediated by Fe2+/H2O2 or 2,2-azobis-(2-amidinopropane) dihydrochloride by the glutathione mimetic tricyclodecan-9-yl-xanthogenate. , 2005, Free radical biology & medicine.

[189]  J. Kang,et al.  The Amyloid-β Peptide Suppresses Transforming Growth Factor-β1-induced Matrix Metalloproteinase-2 Production via Smad7 Expression in Human Monocytic THP-1 Cells* , 2005, Journal of Biological Chemistry.

[190]  C. Oresajo,et al.  Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation‐induced matrix degradation – a review , 2005, International journal of cosmetic science.

[191]  Y. Koshino,et al.  Correlation between astrocyte apoptosis and Alzheimer changes in gray matter lesions in Alzheimer's disease. , 2005, Journal of Alzheimer's disease : JAD.

[192]  S. Roßner,et al.  Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme , 2005 .

[193]  J. Trojanowski,et al.  Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. , 2004, The American journal of pathology.

[194]  M. A. Cruz-Höfling,et al.  Mechanisms involved in the blood–brain barrier increased permeability induced by Phoneutria nigriventer spider venom in rats , 2004, Brain Research.

[195]  R. Schliebs,et al.  Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology , 2004, International Journal of Developmental Neuroscience.

[196]  R. Deane,et al.  RAGE (Yin) Versus LRP (Yang) Balance Regulates Alzheimer Amyloid &bgr;-Peptide Clearance Through Transport Across the Blood–Brain Barrier , 2004, Stroke.

[197]  T. Iwatsubo,et al.  [Amyloid beta peptide]. , 2004, Nihon rinsho. Japanese journal of clinical medicine.

[198]  J. Trojanowski,et al.  Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis , 2004, Journal of Neuroinflammation.

[199]  N. Bresolin,et al.  MCP-1 in Alzheimer’s disease patients: A-2518G polymorphism and serum levels , 2004, Neurobiology of Aging.

[200]  D. Butterfield,et al.  Amyloid β‐Peptide(1‐42) Contributes to the Oxidative Stress and Neurodegeneration Found in Alzheimer Disease Brain , 2004, Brain pathology.

[201]  T. Lehtimäki,et al.  Interaction between matrix metalloproteinase 3 and the ε4 allele of apolipoprotein E increases the risk of Alzheimer’s disease in Finns , 2004, Neuroscience Letters.

[202]  Mushfiquddin Khan,et al.  Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. , 2004, Free radical biology & medicine.

[203]  A. Karameris,et al.  Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas/Apo-1 and Bcl-2 in oral lichen planus. , 2004, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[204]  H. Forman,et al.  Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. , 2004, American journal of physiology. Cell physiology.

[205]  D. Lahiri,et al.  Metal and inflammatory targets for Alzheimer's disease. , 2004, Current drug targets.

[206]  G. Wenk,et al.  Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors , 2004, Journal of Neuroinflammation.

[207]  S. Paul,et al.  Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.

[208]  R. Sultana,et al.  Protective Effect of the Xanthate, D609, on Alzheimer's Amyloid β-peptide (1–42)-induced Oxidative Stress in Primary Neuronal Cells , 2004, Free radical research.

[209]  C. Cervellati,et al.  Oxygen, reactive oxygen species and tissue damage. , 2004, Current pharmaceutical design.

[210]  R. Black,et al.  Identification and Characterization of 4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a Novel Dual Tumor Necrosis Factor-α-Converting Enzyme/Matrix Metalloprotease Inhibitor for the Treatment of Rheumatoid Arthritis , 2004, Journal of Pharmacology and Experimental Therapeutics.

[211]  C. Brosnan,et al.  Interleukin-1β Induces a Reactive Astroglial Phenotype via Deactivation of the Rho GTPase–Rock Axis , 2004, The Journal of Neuroscience.

[212]  Carol A. Miller,et al.  Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[213]  D. Gambi,et al.  Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines , 2004, Journal of Neuroimmunology.

[214]  Xudong Huang,et al.  Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology , 2004, Annals of the New York Academy of Sciences.

[215]  M. Meseguer,et al.  Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. , 2004, Asian journal of andrology.

[216]  M. Duchen,et al.  β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase , 2004, The Journal of Neuroscience.

[217]  Mark P Mattson,et al.  Neuronal and glial calcium signaling in Alzheimer's disease. , 2003, Cell calcium.

[218]  J. Aarli,et al.  Role of cytokines in neurological disorders. , 2003, Current medicinal chemistry.

[219]  Norman Relkin,et al.  Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease , 2003, Neurochemistry International.

[220]  M. Tabaton,et al.  Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis. , 2003, Free radical biology & medicine.

[221]  K. Blennow,et al.  Inflammatory Markers in Matched Plasma and Cerebrospinal Fluid from Patients with Alzheimer’s Disease , 2003, Dementia and Geriatric Cognitive Disorders.

[222]  Wei Zhu,et al.  Inflammation and proinflammatory cytokine production, but no demyelination of facial nerves, in experimental autoimmune neuritis in Lewis rats , 2003, Journal of Neuroimmunology.

[223]  I. Alexa,et al.  [Oxidative stress in atherosclerosis]. , 2003, Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.

[224]  Ann Marie Schmidt,et al.  RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain , 2003, Nature Medicine.

[225]  K. Moore,et al.  CD36 Mediates the Innate Host Response to β-Amyloid , 2003, The Journal of experimental medicine.

[226]  F. Lopera,et al.  El daño nuclear neuronal se correlaciona con la detección in situ de los factores de transcripción c­Jun, factor nuclear kB, p53 y Par­4 en la enfermedad de Alzheimer , 2003 .

[227]  A. Delacourte,et al.  Association of atp synthase α-chain with neurofibrillary degeneration in alzheimer’s disease , 2003, Neuroscience.

[228]  Brian J Cummings,et al.  The Induction of the TNFα Death Domain Signaling Pathway in Alzheimer's Disease Brain , 2003, Neurochemical Research.

[229]  R. Vassar,et al.  β-Secretase (BACE) as a drug target for alzheimer’s disease , 2002 .

[230]  Y. Suh,et al.  Molecular mechanisms underlying cyclic AMP inhibition of macrophage dependent TNF-α production and neurotoxicity in response to amyloidogenic C-terminal fragment of Alzheimer's amyloid precursor protein , 2002, Journal of Neuroimmunology.

[231]  J. Haddad.  Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. , 2002, Cellular signalling.

[232]  A. Bush.  Metal complexing agents as therapies for Alzheimer’s disease , 2002, Neurobiology of Aging.

[233]  D. Lahiri,et al.  Regulation of Promoter Activity of the APP Gene by Cytokines and Growth Factors , 2002, Annals of the New York Academy of Sciences.

[234]  T. Miyakawa.  Vascular Pathology in Alzheimer's Disease , 2002, Annals of the New York Academy of Sciences.

[235]  I. Blasig,et al.  Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood−brain barrier , 2002, Neuropharmacology.

[236]  J. Haddad.  Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-κB , 2002, Critical care.

[237]  B. Solomon,et al.  Antibodies to β-Amyloid Decrease the Blood-to-Brain Transfer of β-Amyloid Peptide1 , 2002, Experimental biology and medicine.

[238]  C. Velez-Pardo,et al.  Aβ[25–35] Peptide and Iron Promote Apoptosis in Lymphocytes by an Oxidative Stress Mechanism: Involvement of H2O2, Caspase-3, NF-κB, p53 and c-Jun , 2002 .

[239]  T. Golde.  Inflammation takes on Alzheimer disease , 2002, Nature Medicine.

[240]  R. Dean,et al.  Oxidation of DNA, proteins and lipids by DOPA, protein-bound DOPA, and related catechol(amine)s. , 2002, Toxicology.

[241]  A. Ghiani,et al.  Chemokines and Pro-Inflammatory Cytokines in Down’s Syndrome: An Early Marker for Alzheimer-Type Dementia? , 2002, Psychotherapy and Psychosomatics.

[242]  D. Butterfield,et al.  Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress , 2002 .

[243]  D. Butterfield,et al.  Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer’s amyloid β-peptide (1–42) , 2002 .

[244]  M. Grundman,et al.  Antioxidant strategies for Alzheimer's disease , 2002, Proceedings of the Nutrition Society.

[245]  C. Behl,et al.  Oxidative Nerve Cell Death in Alzheimers Disease and Stroke: Antioxidants as Neuroprotective Compounds , 2002, Biological chemistry.

[246]  S. Roggo.  Inhibition of BACE, a promising approach to Alzheimer's disease therapy. , 2002, Current topics in medicinal chemistry.

[247]  R. Kalaria.  Small Vessel Disease and Alzheimer’s Dementia: Pathological Considerations , 2002, Cerebrovascular Diseases.

[248]  J. Bading,et al.  Brain Clearance of Alzheimer's Amyloid-β40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerebral Amyloid Angiopathy , 2002, Journal of drug targeting.

[249]  Peter Schubert,et al.  Glia-related pathomechanisms in Alzheimer's disease: a therapeutic target? , 2001, Mechanisms of Ageing and Development.

[250]  Taku Sugawara,et al.  Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[251]  T. Arendt,et al.  Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer’s disease , 2001, Brain Research.

[252]  S. Paul,et al.  Neuronal DNA damage correlates with overexpression of interleukin-1β converting enzyme in APPV717F mice , 2001, Neurobiology of Aging.

[253]  J. Overmier,et al.  Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice , 2001, Neurobiology of Aging.

[254]  R. Nitsch,et al.  Genetics of interleukin 6: implications for Alzheimer’s disease , 2001, Neurobiology of Aging.

[255]  G. Cole,et al.  The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse , 2001, The Journal of Neuroscience.

[256]  W. Streit,et al.  Chemokines and Alzheimer’s disease , 2001, Neurobiology of Aging.

[257]  R. Mrak,et al.  The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer’s disease , 2001, Neurobiology of Aging.

[258]  N. Rothwell,et al.  Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1. , 2001, Brain research. Molecular brain research.

[259]  T. Squier,et al.  Oxidative stress and protein aggregation during biological aging , 2001, Experimental Gerontology.

[260]  K. Roth.  Caspases, Apoptosis, and Alzheimer Disease: Causation, Correlation, and Confusion , 2001, Journal of neuropathology and experimental neurology.

[261]  D. Butterfield,et al.  D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. , 2001, The Journal of pharmacology and experimental therapeutics.

[262]  R. Bonavia,et al.  Chemokines and Their Receptors in the Central Nervous System , 2001, Frontiers in Neuroendocrinology.

[263]  Virginia M. Y. Lee,et al.  Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis , 2001, The Journal of Neuroscience.

[264]  E. Melamed,et al.  Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier , 2001, Neuropharmacology.

[265]  H. Suh,et al.  Protection against β‐amyloid peptide toxicity in vivo with long‐term administration of ferulic acid , 2001, British journal of pharmacology.

[266]  D. Rampe,et al.  Amyloid‐β peptide fragments p3 and p4 induce pro‐inflammatory cytokine and chemokine production in vitro and in vivo , 2001 .

[267]  D. Rampe,et al.  Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo. , 2001, Journal of neurochemistry.

[268]  R. Schliebs,et al.  β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology , 2001, Brain Research.

[269]  D S Sharp,et al.  Polymorphisms of the IL-1 gene complex in coal miners with silicosis. , 2001, American journal of industrial medicine.

[270]  G. Landreth,et al.  β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis , 2001, The Journal of Neuroscience.

[271]  A. M. Szczepanik,et al.  IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line , 2001, Journal of Neuroimmunology.

[272]  J. Barnes,et al.  Oxidative signalling and inflammatory pathways in Alzheimer's disease. , 2001, Biochemical Society symposium.

[273]  J. Parks,et al.  Neurotoxic Aβ peptides increase oxidative stress in vivo through NMDA‐receptor and nitric‐oxide‐synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro , 2001, Journal of neurochemistry.

[274]  R. Berge,et al.  Interaction between chemokines and oxidative stress: possible pathogenic role in acute coronary syndromes. , 2001, Journal of the American College of Cardiology.

[275]  D. Shin,et al.  Protective effect of 4′, 5-dihydroxy-3′,6,7-trimethoxyflavone from Artemisia asiatica against Aβ-induced oxidative stress in PC12 cells , 2001 .

[276]  Y. L. Lin,et al.  Involvement of oxidative stress, NF-IL-6, and RANTES expression in dengue-2-virus-infected human liver cells. , 2000, Virology.

[277]  B. Oderfeld‐Nowak,et al.  Long-term microglial and astroglial activation in the hippocampus of trimethyltin-intoxicated rat: stimulation of NGF and TrkA immunoreactivities in astroglia but not in microglia , 2000, International Journal of Developmental Neuroscience.

[278]  C. Morris,et al.  Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease , 2000, Neuroscience Letters.

[279]  J. Wands,et al.  Mitochondrial DNA Damage as a Mechanism of Cell Loss in Alzheimer's Disease , 2000, Laboratory Investigation.

[280]  C. Dinarello.  Impact of Basic Research On Tomorrow's MedicineProinflammatory Cytokines , 2000 .

[281]  M. Smith,et al.  Oxidative stress in Alzheimer's disease. , 2000, Biochimica et biophysica acta.

[282]  R. Schliebs,et al.  Induction of cytokines in glial cells surrounding cortical β-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology , 2000, International Journal of Developmental Neuroscience.

[283]  A. Bush,et al.  Oxidative processes in Alzheimer's disease: the role of Aβ-metal interactions , 2000, Experimental Gerontology.

[284]  Y. Ihara,et al.  Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. , 2000, Biochemistry.

[285]  E. Gwebu,et al.  Aged garlic extract suppresses lipid peroxidation induced by β-amyloid in PC12 cells , 2000, In Vitro Cellular & Developmental Biology - Animal.

[286]  J. Harrison,et al.  Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis , 2000, Journal of Neuroimmunology.

[287]  U. Haberkorn,et al.  Apoptosis modulators in the therapy of neurodegenerative diseases , 2000, Expert opinion on investigational drugs.

[288]  Y. Christen,et al.  Oxidative stress and Alzheimer disease. , 2000, The American journal of clinical nutrition.

[289]  G. Landreth,et al.  Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists , 2000, The Journal of Neuroscience.

[290]  T. Hattori,et al.  Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer’s disease brain , 2000, Acta Neuropathologica.

[291]  L. Moldawer,et al.  TNF-α Receptor Signaling and IL-10 Gene Therapy Regulate the Innate and Humoral Immune Responses to Recombinant Adenovirus in the Lung1 , 2000, The Journal of Immunology.

[292]  M. Selassie,et al.  Effect of Aged Garlic Extract on the Cytotoxicity of Alzheimer β-Amyloid Peptide in Neuronal PC12 Cells , 2000, Nutritional neuroscience.

[293]  H. Jockusch,et al.  Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse. , 1999, Neuroreport.

[294]  C. Culmsee,et al.  Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases , 1999, Annals of the New York Academy of Sciences.

[295]  S. Sorbi,et al.  Oxidative Stress and a Key Metabolic Enzyme in Alzheimer Brains, Cultured Cells, and an Animal Model of Chronic Oxidative Deficits , 1999, Annals of the New York Academy of Sciences.

[296]  J. Treanor,et al.  Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.

[297]  S. Govoni,et al.  Protein Kinase C Anchoring Deficit in Postmortem Brains of Alzheimer's Disease Patients , 1999, Experimental Neurology.

[298]  C. Masters,et al.  Aqueous Dissolution of Alzheimer’s Disease Aβ Amyloid Deposits by Biometal Depletion* , 1999, The Journal of Biological Chemistry.

[299]  K. Furuuchi,et al.  Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier. , 1999, Biochemical and biophysical research communications.

[300]  K. Blennow,et al.  Intracerebral Production of Tumor Necrosis Factor-α, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia , 1999, Journal of Clinical Immunology.

[301]  C. Oliveira,et al.  Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants , 1999, Neurobiology of Disease.

[302]  R. Schröder,et al.  Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern , 1999, Virchows Archiv.

[303]  D. Butterfield,et al.  In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42) , 1999, Neurobiology of aging.

[304]  W. Markesbery,et al.  Oxidative Alterations in Alzheimer's Disease , 1999, Brain pathology.

[305]  S. Love.  Oxidative Stress in Brain Ischemia , 1999, Brain pathology.

[306]  T. Taniguchi,et al.  Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease. , 1998, Alzheimer disease and associated disorders.

[307]  L. Sekut,et al.  AntiTNF-a agents in the treatment of inflammation , 1998 .

[308]  G. Rosenberg,et al.  Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. , 1998, Stroke.

[309]  S. Lorenzl,et al.  Matrix metalloproteinases contribute to the blood—brain barrier disruption during bacterial meningitis , 1998, Annals of neurology.

[310]  E. Woodle,et al.  Programmed cell death. , 1998, Transplantation.

[311]  G. Brewer,et al.  Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. , 1998, Brain research. Molecular brain research.

[312]  B. Bradt,et al.  Complement-dependent Proinflammatory Properties of the Alzheimer's Disease β-Peptide , 1998, Journal of Experimental Medicine.

[313]  B. Hyman,et al.  Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains , 1998 .

[314]  B. Winblad,et al.  Genetiska faktorer ligger ofta bakom Alzheimers sjukdom : Stor tvillingstudie skall klarlägga sambanden arv-miljö , 1998 .

[315]  L. Mucke,et al.  Amyloid Protein Precursor Stimulates Excitatory Amino Acid Transport , 1998, The Journal of Biological Chemistry.

[316]  C. Albanese,et al.  Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism , 1998 .

[317]  M. Tabaton,et al.  Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress , 1998, Journal of neurochemistry.

[318]  P. Schubert,et al.  Interfering with the Pathologic Activation of Microglial Cells and Astrocytes in Dementia , 1998, Alzheimer disease and associated disorders.

[319]  Y. Kitamura.  [Functional activation of glial cells in early and delayed episodes of the brain damage]. , 1998, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[320]  C. Cotman,et al.  Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease , 1998, Neurobiology of Aging.

[321]  H. Vinters,et al.  Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. , 1998, The American journal of pathology.

[322]  G. Stoica,et al.  Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-α in the central nervous system , 1998, Brain Research.

[323]  D. Davies,et al.  Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain , 1997, Neuroscience Letters.

[324]  E. Conway,et al.  Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and α 2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat , 1997, Neuroscience.

[325]  D. Butterfield,et al.  Oxidative modification of glutamine synthetase by amyloid beta peptide. , 1997, Free radical research.

[326]  R. Kalaria.  Cerebrovascular Degeneration Is Related to Amyloid‐β Protein Deposition in Alzheimer's Disease a , 1997 .

[327]  F. Paoletti,et al.  Cysteine proteinases are responsible for characteristic transketolase alterations in Alzheimer fibroblasts , 1997, Journal of cellular physiology.

[328]  R. Wurtman,et al.  Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[329]  M. Gearing,et al.  Astrocyte‐Apolipoprotein E Associations in Senile Plaques in Alzheimer Disease and Vascular Lesions: A Regional Immunohistochemical Study , 1997, Journal of neuropathology and experimental neurology.

[330]  R. Mrak,et al.  Glial‐Neuronal Interactions in Alzheimer Disease: Progressive Association of IL‐1α+ Microglia and S100β+ Astrocytes with Neurofibrillary Tangle Stages , 1997, Journal of neuropathology and experimental neurology.

[331]  D. Walker,et al.  Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α , 1997, Brain Research.

[332]  Michael J. Cullen,et al.  Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40) , 1996, The Journal of Neuroscience.

[333]  D. Lawrence,et al.  Surface thiols of human lymphocytes and their changes after in vitro and in vivo activation , 1996, Journal of leukocyte biology.

[334]  G. Kollias,et al.  Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response , 1996, The Journal of experimental medicine.

[335]  L. Honig,et al.  Genetic factors for the development of Alzheimer disease in the Cherokee Indian. , 1996, Archives of neurology.

[336]  P. Mcgeer,et al.  Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease , 1996, Brain Research.

[337]  M. Matsumoto,et al.  Rage: A Novel Cellular Receptor for Advanced Glycation End Products , 1996, Diabetes.

[338]  J. Joseph,et al.  Oxidative stress and age-related neuronal deficits , 1996, Molecular and chemical neuropathology.

[339]  G. Glinsky,et al.  Apoptosis and metastasis: a superior resistance of metastatic cancer cells to programmed cell death , 1996 .

[340]  M. Brownlee,et al.  BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells. , 1996, The Journal of clinical investigation.

[341]  S. Orrenius,et al.  Signalling mechanisms and oxidative stress in apoptosis. , 1995, Toxicology letters.

[342]  D. Price,et al.  Amyloid beta amyloidosis in Alzheimer's disease. , 1995, Current opinion in neurology.

[343]  W. Griffin,et al.  Microglial inter leukin‐1α expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution , 1995, Neuropathology and applied neurobiology.

[344]  G. Gibson,et al.  Blood-Brain Barrier Abnormalities in Vulnerable Brain Regions during Thiamine Deficiency , 1995, Experimental Neurology.

[345]  Y. Agid.  [Aging, disease and nerve cell death]. , 1995, Bulletin de l'Academie nationale de medecine.

[346]  G. Forloni,et al.  Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures , 1995, Neuroscience Letters.

[347]  D. Price,et al.  Role of the β‐amyloid protein in Alzheimer's disease , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[348]  R. Mrak,et al.  Interleukin‐1 Expression in Different Plaque Types in Alzheimer's Disease: Significance in Plaque Evalution , 1995, Journal of neuropathology and experimental neurology.

[349]  J. Whitson,et al.  Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade , 1995, Neurobiology of Aging.

[350]  C. Gabel,et al.  Inhibition of cytokine activation processes in vitro by tenidap, a novel anti-inflammatory agent. , 1995, Cytokine.

[351]  M. Mattson.  Calcium and Neuronal Injury in Alzheimer's Disease , 1994, Annals of the New York Academy of Sciences.

[352]  H. Wiśniewski,et al.  Non‐Fibrillar β‐Amyloid Protein is Associated with Smooth Muscle Cells of Vessel Walls in Alzheimer Disease , 1994, Journal of neuropathology and experimental neurology.

[353]  D. Graham,et al.  Microglial interleukin-lα expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression , 1994, Neuroscience Letters.

[354]  K. Williams,et al.  Activation of adult human derived microglia by myelin phagocytosis in vitro , 1994, Journal of neuroscience research.

[355]  M. Huberman,et al.  Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients , 1994, Neuroscience Letters.

[356]  R. Mrak,et al.  Glial Cytokines as Neuropathogenic Factors in HIV Infection: Pathogenic Similarities to Alzheimer's Disease , 1994, Journal of neuropathology and experimental neurology.

[357]  F. Paoletti,et al.  Characteristic transketolase alterations in dermal fibroblasts of Alzheimer patients are modulated by culture conditions. , 1994, Experimental and molecular pathology (Print).

[358]  H. Baumann,et al.  Divergent transforming growth factor-beta effects on IL-6 regulation of acute phase plasma proteins in rat hepatoma cells. , 1993, Journal of immunology.

[359]  R. Reiter.  Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review. , 1993, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[360]  M. Mattson,et al.  β‐Amyloid Precursor Protein Mismetabolism and Loss of Calcium Homeostasis in Alzheimer's Disease a , 1993 .

[361]  J. D. L. Torre,et al.  Can disturbed brain microcirculation cause Alzheimer’s disease? , 1993 .

[362]  D. Dickson,et al.  Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease , 1993, Glia.

[363]  I. Romero,et al.  Astrocyte‐endothelial interaction: physiology and pathology , 1992, Neuropathology and applied neurobiology.

[364]  R. Rosenberg,et al.  Morphological differentiation and proteoglycan synthesis regulate Alzheimer amyloid precursor protein processing in PC‐12 and human astrocyte cultures , 1992, Journal of neuroscience research.

[365]  G. P. Duboiskaya,et al.  Structural and functional changes of blood-brain barrier and indication of prion amyloid filaments in experimental amyotrophic leucospongiosis. , 1992, Acta virologica.

[366]  M. Mattson,et al.  beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[367]  Carl W. Cotman,et al.  In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity , 1991, Brain Research.

[368]  L. Buée,et al.  Elevated circulating tumor necrosis factor levels in Alzheimer's disease , 1991, Neuroscience Letters.

[369]  M. Vitek,et al.  Interleukin-1 stimulates the beta-amyloid precursor protein promoter , 1990, Cellular and Molecular Neurobiology.

[370]  R. Kalaria,et al.  The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. , 1990, The American journal of pathology.

[371]  P. Crino,et al.  Involvement of free radicals in dementia of the Alzheimer type: A hypothesis , 1990, Neurobiology of Aging.

[372]  A. Hirano,et al.  [The astrocyte-endothelial interface in cerebellar astrocytoma]. , 1989, No shinkei geka. Neurological surgery.

[373]  R N Kalaria,et al.  Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease , 1989, Journal of neurochemistry.

[374]  H. W. Harris,et al.  Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[375]  M. Vitek,et al.  Focusing on IL1-promotion of β-amyloid precursor protein synthesis as an early event in Alzheimer's disease , 1989, Neurobiology of Aging.

[376]  W. Pardridge.  Does the brain's gatekeeper falter in aging? , 1988, Neurobiology of Aging.

[377]  Rogert D. Burgoyne,et al.  Neuronal calcium , 1987, Trends in Neurosciences.

[378]  B. Winblad,et al.  Blood-brain barrier in Alzheimer dementia and in non-demented elderly , 1987, Acta Neuropathologica.

[379]  Ma Gj.  The relationship of astrocyte activation and fibrous gliosis to the development of Alzheimer type I cells in Wilson disease , 1987 .

[380]  H. Wiśniewski,et al.  Increased Blood‐Brain Barrier Permeability in Scrapie‐Infected Mice , 1983, Journal of neuropathology and experimental neurology.

[381]  F. Stam,et al.  Some Cerebral Proteins and Enzyme Systems in Alzheimer's Presenile and Senile Dementia , 1976, Journal of the American Geriatrics Society.

[382]  D. B. Seeley,et al.  Ultraviolet Radiation , 1952, The Yale Journal of Biology and Medicine.

[383]  G. Aliev.  Oxidative stress induced-metabolic imbalance, mitochondrial failure, and cellular hypoperfusion as primary pathogenetic factors for the development of Alzheimer disease which can be used as a alternate and successful drug treatment strategy: past, present and future. , 2011, CNS & neurological disorders drug targets.

[384]  James B. Mitchell,et al.  Brain redox imaging. , 2011, Methods in molecular biology.

[385]  Guangjun Nie,et al.  β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. , 2011, Free radical biology & medicine.

[386]  B. Eliceiri,et al.  Zebrafish model of the blood-brain barrier: morphological and permeability studies. , 2011, Methods in molecular biology.

[387]  S. Minger,et al.  Progress and prospects: stem cells and neurological diseases , 2011, Gene Therapy.

[388]  V. Finder.  Alzheimer's disease: a general introduction and pathomechanism. , 2010, Journal of Alzheimer's disease : JAD.

[389]  D. Butterfield,et al.  In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. , 2010, Free radical biology & medicine.

[390]  A. Strongin.  Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy. , 2010, Biochimica et biophysica acta.

[391]  Manjeet Singh,et al.  Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein. , 2010, Journal of Alzheimer's disease : JAD.

[392]  D. Butterfield,et al.  Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration. , 2010, Journal of Alzheimer's disease : JAD.

[393]  R. Kizek,et al.  Matrix metalloproteinases. , 2010, Current medicinal chemistry.

[394]  J. Simpkins,et al.  Amyloid-β peptide fibrils induce nitro-oxidative stress in neuronal cells. , 2010, Journal of Alzheimer's disease : JAD.

[395]  M. Mancuso,et al.  Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA. , 2010, Advances in experimental medicine and biology.

[396]  A. Planas,et al.  In vitro and in vivo activation of astrocytes by amyloid-beta is potentiated by pro-oxidant agents. , 2010, Journal of Alzheimer's disease : JAD.

[397]  W. V. Van Nostrand,et al.  Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro. , 2010, Biochemistry.

[398]  S. Yan,et al.  RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation? , 2009, Journal of Alzheimer's disease : JAD.

[399]  S. M. Robinson,et al.  Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. , 2009, Journal of Alzheimer's disease : JAD.

[400]  Journal of Neuroinflammation BioMed Central , 2008 .

[401]  D. Butterfield,et al.  Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid beta-peptide. , 2008, Molecular bioSystems.

[402]  M. Pallàs,et al.  Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches. , 2008, Methods and findings in experimental and clinical pharmacology.

[403]  M. Mattson,et al.  Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. , 2008, Journal of neurochemistry.

[404]  E. Pylaeva,et al.  [Reactive oxygen species and redox-signaling during adaptation to changes of oxygen level]. , 2008, Fiziolohichnyĭ zhurnal.

[405]  G. Perry,et al.  From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). , 2008, Journal of Alzheimer's disease : JAD.

[406]  James L. Buescher,et al.  Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. , 2007, The American journal of pathology.

[407]  Alessandro Serretti,et al.  Genetics of Alzheimer's disease. A rapidly evolving field. , 2007, Journal of Alzheimer's disease : JAD.

[408]  D. Butterfield,et al.  Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. , 2007, Free radical biology & medicine.

[409]  R. Cappai,et al.  The redox chemistry of the Alzheimer's disease amyloid beta peptide. , 2007, Biochimica et biophysica acta.

[410]  P. Grammas,et al.  Expression of macrophage inflammatory protein 1-alpha is elevated in Alzheimer's vessels and is regulated by oxidative stress. , 2007, Journal of Alzheimer's disease : JAD.

[411]  R. N. Takahashi,et al.  Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein. , 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[412]  J. Pincemail,et al.  [Oxidative stress]. , 2007, Revue medicale de Liege.

[413]  D. Butterfield,et al.  Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. , 2007, Frontiers in bioscience : a journal and virtual library.

[414]  James L. Buescher,et al.  Interferon-and Tumor Necrosis Factor-Regulate Amyloid-Plaque Deposition and-Secretase Expression in Swedish Mutant APP Transgenic Mice , 2007 .

[415]  P. Grammas,et al.  Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease. , 2006, Journal of Alzheimer's disease : JAD.

[416]  M. Kingsley.  Effects of Phosphatidylserine Supplementation on Exercising Humans , 2006, Sports medicine.

[417]  E. Levy,et al.  Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant. , 2006, Journal of Alzheimer's disease : JAD.

[418]  E. Hansson,et al.  Astrocyte–endothelial interactions at the blood–brain barrier , 2006, Nature Reviews Neuroscience.

[419]  A. Schmidt,et al.  [Glycation, glycoxidation and diabetes mellitus]. , 2006, Néphrologie & Thérapeutique.

[420]  M. Hüll,et al.  Inflammatory mechanisms in Alzheimer's disease , 2005, European Archives of Psychiatry and Clinical Neuroscience.

[421]  R. von Bernhardi,et al.  Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. , 2005, Biological research.

[422]  J. Kang,et al.  The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells. , 2005, The Journal of biological chemistry.

[423]  B. Winblad,et al.  1 INVOLVEMENT OF GLUTAREDOXIN-1 AND THIOREDOXIN-1 IN BETA AMYLOID TOXICITY AND ALZHEIMER ’ S DISEASE , 2005 .

[424]  K. Herold,et al.  RAGE: a journey from the complications of diabetes to disorders of the nervous system - striking a fine balance between injury and repair. , 2005, Restorative neurology and neuroscience.

[425]  J. Perez-polo,et al.  Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. , 2005, Journal of neurochemistry.

[426]  K. Hensley,et al.  Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. , 2004, Journal of Alzheimer's disease : JAD.

[427]  Henry Jay Forman,et al.  Redox signaling , 2004, Molecular and Cellular Biochemistry.

[428]  R. Vassar.  BACE1: the beta-secretase enzyme in Alzheimer's disease. , 2004, Journal of molecular neuroscience : MN.

[429]  J. Trojanowski,et al.  Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. , 2004, The American journal of pathology.

[430]  D. Butterfield,et al.  The Glutamatergic System and Alzheimer’s Disease , 2003, CNS drugs.

[431]  A. Delacourte,et al.  Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease. , 2003, Neuroscience.

[432]  Brian J Cummings,et al.  The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. , 2003, Neurochemical research.

[433]  G. Münch,et al.  Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y. , 2003, Journal of Alzheimer's disease : JAD.

[434]  E. Melamed,et al.  Antioxidant treatment in alzheimer’s disease , 2003, Journal of Molecular Neuroscience.

[435]  R. Vassar.  Beta-secretase (BACE) as a drug target for Alzheimer's disease. , 2002, Advanced drug delivery reviews.

[436]  C. Velez-Pardo,et al.  Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun. , 2002, Neurotoxicology.

[437]  Charles A. Harris,et al.  Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice , 2002 .

[438]  D. Butterfield,et al.  Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists. , 2002, Journal of Alzheimer's disease : JAD.

[439]  D. Holtzman,et al.  Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice. , 2001, Journal of Alzheimer's disease : JAD.

[440]  D. Cechetto.  Role of nuclear factor kappa B in neuropathological mechanisms. , 2001, Progress in brain research.

[441]  A. Drewnowski,et al.  Journals of Gerontology , 2001 .

[442]  Scott R. Barnum,et al.  INFLAMMATION AND ALZHEIMERS DISEASE , 2000 .

[443]  Miles W. Miller,et al.  Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice , 1999, Nature Medicine.

[444]  B T Hyman,et al.  Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. , 1999, Journal of neurovirology.

[445]  S. Kato,et al.  [Glutathione S-transferase]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.

[446]  W. Buurman,et al.  Soluble TNF receptors , 1999 .

[447]  B. Rollins,et al.  Monocyte chemoattractant protein-1. , 1999, Chemical immunology.

[448]  B. Winblad,et al.  [Genetic factors are often found inl Alzheimer disease. An extensive twin study to clarify the heredity-environment relationship]. , 1998, Läkartidningen.

[449]  C. Albanese,et al.  Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[450]  L. Sekut,et al.  AntiTNF-alpha agents in the treatment of inflammation. , 1998, Expert opinion on investigational drugs.

[451]  B. Hyman,et al.  Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. , 1998, The American journal of pathology.

[452]  T. Wright,et al.  Cytokines in acute and chronic inflammation. , 1997, Frontiers in bioscience : a journal and virtual library.

[453]  D. Walker,et al.  Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha. , 1997, Brain research.

[454]  A. Cuvelier,et al.  [Metalloproteinases in the extracellular matrix: structure and activity]. , 1997, Revue des maladies respiratoires.

[455]  A. Newby,et al.  Extracellular matrix degrading metalloproteinases in the pathogenesis of arteriosclerosis. , 1994, Basic research in cardiology.

[456]  M. Mattson,et al.  Glutamate, beta-amyloid precursor proteins, and calcium mediated neurofibrillary degeneration. , 1994, Journal of neural transmission. Supplementum.

[457]  C. Cotman,et al.  In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. , 1991, Brain research.

[458]  J. Blass,et al.  The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease. , 1991, Revue neurologique.

[459]  A D Roses,et al.  Genetics of Alzheimer's disease. , 1991, International journal of neurology.

[460]  V. P. Fedorov,et al.  [Structuro-functional organization of the blood-brain barrier]. , 1989, Известия Российской академии наук Серия биологическая.

[461]  Ushakov Ib,et al.  [Structuro-functional organization of the blood-brain barrier]. , 1989 .

[462]  H. Thoenen,et al.  Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve , 1987, Nature.

[463]  G. Ma.  [The relationship of astrocyte activation and fibrous gliosis to the development of Alzheimer type I cells in Wilson disease]. , 1987, Zhonghua bing li xue za zhi = Chinese journal of pathology.